Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial

scientific article published in May 2003

Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1001/JAMA.289.20.2651
P698PubMed publication ID12771112
P5875ResearchGate publication ID10739588

P50authorJean Wactawski-WendeQ30001860
Sylvia Wassertheil-SmollerQ30002263
Leon J. ThalQ56839882
Rebecca D. JacksonQ72504541
Judith K. OckeneQ113389547
Sally A ShumakerQ114424439
Stephen R. RappQ124352318
P2093author name stringSusan L Hendrix
Robert B Wallace
Claudine Legault
Annlouise R Assaf
Jane Morley Kotchen
WHIMS Investigators
Beverly N Jones
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectdementiaQ83030
estrogenQ277954
mild cognitive impairmentQ1472703
cognitive dysfunctionQ57859955
P304page(s)2651-2662
P577publication date2003-05-01
P1433published inThe Journal of the American Medical AssociationQ1470970
P1476titleEstrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial
P478volume289

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cites work (P2860)
Q3382573617α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 mice.
Q5603112117α-estradiol: a less-feminizing estrogen
Q4483261117β-Estradiol, but not estrone, increases the survival and activation of new neurons in the hippocampus in response to spatial memory in adult female rats.
Q3632313817β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain
Q450499233beta-20beta-dihydroxy-5alpha-pregnane (UC1011) antagonism of the GABA potentiation and the learning impairment induced in rats by allopregnanolone
Q57157080A Heartfelt Message, Estrogen Replacement Therapy: Use It or Lose It
Q38846232A comparison of progestins within three classes: Differential effects on learning and memory in the aging surgically menopausal rat.
Q34316221A component of Premarin® enhances multiple cognitive functions and influences nicotinic receptor expression
Q36290901A conceptual model of cognitive deficits in chronic heart failure
Q33745024A cross-sectional study of hormone treatment and hippocampal volume in postmenopausal women: evidence for a limited window of opportunity
Q38023908A decade post WHI, menopausal hormone therapy comes full circle--need for independent commission
Q35986045A lack of ovarian function increases neuroinflammation in aged mice
Q92158594A long-term cyclic plus tonic regimen of 17β-estradiol improves the ability to handle a high spatial working memory load in ovariectomized middle-aged female rats
Q35198034A mechanism emerges for the critical period hypothesis for estrogen treatment
Q37070656A network model of genomic hormone interactions underlying dementia and its translational validation through serendipitous off-target effect
Q33925274A new approach to understanding the molecular mechanisms through which estrogens affect cognition
Q24792589A philosophical analysis of the evidence-based medicine debate
Q35634150A pilot randomized, single-blind, placebo-controlled trial of traditional acupuncture for vasomotor symptoms and mechanistic pathways of menopause
Q39364029A practical guide to the management of menopausal symptoms in breast cancer patients
Q24657278A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women
Q36428962A review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior
Q34250612A second chance for hormone replacement therapy?
Q90263988Accelerated Ovarian Failure as a Unique Model to Study Peri-Menopause Influence on Alzheimer's Disease
Q35850425Actions and interactions of estradiol and glucocorticoids in cognition and the brain: Implications for aging women.
Q34099770Acute responses to estradiol replacement in the olfactory system of apoE-deficient and wild-type mice
Q35322167Advances in the prevention of Alzheimer's disease and dementia
Q55395274Age at menopause and lifetime cognition: Findings from a British birth cohort study.
Q37623629Age-dependent Effects of 17β-estradiol on the dynamics of estrogen receptor β (ERβ) protein-protein interactions in the ventral hippocampus
Q33757617Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice
Q36721813Age-related inflammatory diseases: role of genetics and gender in the pathophysiology of Alzheimer's disease
Q44943067Alendronate in the prevention of osteoporosis: 7-year follow-up
Q44915973Alternatives to hormone replacement therapy for menopause: an epidemiological evaluation
Q30357424Alzheimer 100--highlights in the history of Alzheimer research.
Q38675107Alzheimer Disease: Scientific Breakthroughs and Translational Challenges
Q37638708Alzheimer disease in post-menopausal women: Intervene in the critical window period
Q22252311Alzheimer mechanisms and therapeutic strategies
Q64163825Alzheimer's Disease: Progress in the Development of Anti-amyloid Disease-Modifying Therapies
Q34039983Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments
Q36894385Alzheimer's disease and mild cognitive impairment
Q36946824Alzheimer's disease and other neurological disorders
Q39629610Alzheimer's disease therapeutic trials: EU/US Task Force report on recruitment, retention, and methodology
Q30620862Alzheimer's disease, dementia, mild cognitive impairment and the menopause: a 'window of opportunity'?
Q57074482Alzheimer's disease, estrogens, and clinical trials: a case study in drug development for complex disorders
Q38871979Alzheimer's disease, menopause and the impact of the estrogenic environment
Q35687044Alzheimer's disease: pathological mechanisms and recent insights
Q37315515Alzheimer's disease: review of hormone therapy trials and implications for treatment and prevention after menopause
Q64060113Alzheimer's disease: risk factors and potentially protective measures
Q33773031Alzheimer's prevention initiative: a proposal to evaluate presymptomatic treatments as quickly as possible
Q35987458Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study
Q46129248An omnibus test for several hazard alternatives in prevention randomized controlled clinical trials
Q37084906An update on the cognitive impact of clinically-used hormone therapies in the female rat: models, mazes, and mechanisms
Q33896147An update on the diagnosis and management of dementing conditions
Q37576090An update on treatment and prevention strategies for Alzheimer's disease
Q35871132Androgen replacement therapy: present and future
Q47332942Anti-aging medicine and research: a realm of conflict and profound societal implications
Q42785187Anti-inflammatory drugs and Alzheimer's disease
Q34066474Antioxidant therapy in Alzheimer's disease: theory and practice
Q38398327Are there cognitive and neurobehavioural correlates of hormonal neuroprotection for women after TBI?
Q35237981Ascertaining dementia-related outcomes for deceased or proxy-dependent participants: an overview of the Women's Health Initiative Memory Study supplemental case ascertainment protocol
Q36666859Assessing and treating forgetfulness and cognitive problems in adults with HIV
Q37015181Assessment of estradiol influence on spatial tasks and hippocampal CA1 spines: evidence that the duration of hormone deprivation after ovariectomy compromises 17beta-estradiol effectiveness in altering CA1 spines
Q90619967Association Between Hormone-Modulating Breast Cancer Therapies and Incidence of Neurodegenerative Outcomes for Women With Breast Cancer
Q38392550Association of bilateral oophorectomy with cognitive function in healthy, postmenopausal women
Q50986104Attitudes of women who are currently using or recently stopped estrogen replacement therapy with or without progestins: results of the AWARE survey.
Q37262126Behavioral consequences of ovarian atrophy and estrogen replacement in the APPswe mouse
Q50783742Benchmarks for designing two-stage studies using modified mini-mental state examinations: experience from the Women's Health Initiative Memory Study.
Q37483121Benefits of Hormone Therapy Estrogens Depend on Estrogen Type: 17β-Estradiol and Conjugated Equine Estrogens Have Differential Effects on Cognitive, Anxiety-Like, and Depressive-Like Behaviors and Increase Tryptophan Hydroxylase-2 mRNA Levels in Dor
Q35072737Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism
Q24643351Bioidentical hormones for menopausal hormone therapy: variation on a theme
Q91984204Blood pressure variability and brain morphology in elderly women without cardiovascular disease
Q33742116Bone density and brain atrophy in early Alzheimer's disease
Q35539109Bone mineral density in adolescent and young adult women on injectable or oral contraception
Q34563775Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor
Q34244907Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model
Q34091893Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease
Q37413116Brain volumes, cognitive impairment, and conjugated equine estrogens
Q36349176Brain-derived neurotrophic factor Val(66)Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study
Q36106017Building a better hormone therapy? How understanding the rapid effects of sex steroid hormones could lead to new therapeutics for age-related memory decline.
Q35198156C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection
Q36843004CAP--advancing the evaluation of preclinical Alzheimer disease treatments
Q44640274Calcium Channel Blockers (Felodipine) and Pediatric Essential Hypertension
Q36463375Calcium and vitamin D supplementation and cognitive impairment in the women's health initiative
Q37457697Cardiovascular disease and cognitive decline in postmenopausal women: results from the Women's Health Initiative Memory Study
Q36892860Care of the menopausal patient: a nurse practitioner's view
Q81163509Changes in health-related behaviours following BRCA 1/2 genetic testing: the case of hormone replacement therapy
Q35866374Changing concepts: Menopausal hormone therapy and breast cancer
Q34361818Characteristics of hormone therapy, cognitive function, and dementia: the prospective 3C Study.
Q99573908Characterizing the effects of tonic 17β-estradiol administration on spatial learning and memory in the follicle-deplete middle-aged female rat
Q34303501Characterizing the preclinical stages of Alzheimer's disease and the prospect of presymptomatic intervention
Q36107446Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers
Q43438290Chronic administration of tibolone modulates anxiety-like behavior and enhances cognitive performance in ovariectomized rats
Q34978792Chronic treatment with the nitric oxide synthase inhibitor, L-NAME, attenuates estradiol-mediated improvement of learning and memory in ovariectomized rats
Q36072505Clinical appraisal of the Women's Health Initiative
Q47942644Clinical outcomes in older surgical patients with mild cognitive impairment.
Q31155412Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology
Q37810697Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for Psychopharmacology
Q57122063Clinical predictors of older driver performance on a standardized road test
Q36854928Clinically relevant hormone treatments fail to induce spinogenesis in prefrontal cortex of aged female rhesus monkeys
Q35757574Cognition, mood disorders, and sex hormones
Q58551763Cognitive Changes with Reproductive Aging, Perimenopause, and Menopause
Q46153359Cognitive Function and Changes in Cognitive Function as Predictors of Incident Cardiovascular Disease: The Women's Health Initiative Memory Study
Q33761005Cognitive benefits of hormone therapy: cardiovascular factors and healthy-user bias
Q37088621Cognitive changes after menopause: influence of estrogen
Q36919235Cognitive decline and dementia in the oldest-old
Q34070875Cognitive deficits and health-related quality of life in chronic heart failure
Q34070832Cognitive deficits in chronic heart failure
Q36443732Cognitive dysfunction with aging and the role of inflammation
Q38551397Cognitive effects of endocrine therapy for breast cancer: keep calm and carry on?
Q45960420Cognitive effects of short-term use of raloxifene: a randomized clinical trial.
Q36539736Cognitive performance in healthy women during induced hypogonadism and ovarian steroid addback
Q92656269Cognitive resilience among APOE ε4 carriers in the oldest old
Q48305628Cognitive symptoms during the menopausal transition and early postmenopause
Q37207741Cognitive-impairing effects of medroxyprogesterone acetate in the rat: independent and interactive effects across time
Q47711481Combination Therapy for Multi-Target Manipulation of Secondary Brain Injury Mechanisms
Q35152376Combination hormone replacement therapy and dementia
Q35691705Combination of Micronutrients for Bone (COMB) Study: bone density after micronutrient intervention
Q35936864Combination therapy in Alzheimer's disease: a review of current evidence
Q24186056Comparison of central adjudication of outcomes and onsite outcome assessment on treatment effect estimates
Q51968280Comparison of the design differences between the Ginkgo Evaluation of Memory study and the GuidAge study.
Q24682645Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense)
Q37650744Complexities of oestrogen in stroke
Q34974644Concurrent and longitudinal relationships between cognitive activity, cognitive performance, and brain volume in older adult women
Q33600226Consortium to Establish a Registry for Alzheimer's Disease (CERAD): the first twenty years
Q33874451Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice
Q36558503Continuous transdermal nitroglycerin therapy for menopausal hot flashes: a single-arm, dose-escalation trial
Q34185639Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles
Q37642394Continuously delivered ovarian steroids do not alter dendritic spine density or morphology in macaque dorsolateral prefrontal cortical neurons
Q47217248Contrasting effects of individual versus combined estrogen and progestogen regimens as working memory load increases in middle-aged ovariectomized rats: one plus one does not equal two.
Q55517857Correction for retest effects across repeated measures of cognitive functioning: a longitudinal cohort study of postoperative delirium.
Q30634935Critical window hypothesis of hormone therapy and cognition: a scientific update on clinical studies
Q35544962Current Treatment for Alzheimer Disease and Future Prospects
Q36444574Current advances in the treatment of Alzheimer's disease: focused on considerations targeting Aβ and tau.
Q37360292Current concepts in Alzheimer's disease: a multidisciplinary review
Q35618929Current concepts in the prevention of Alzheimer's disease
Q36575001Current treatment of mild cognitive impairment and Alzheimer's disease
Q42170272Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys.
Q33371496Data analysis methods and the reliability of analytic epidemiologic research
Q36993348Decreased oxidant profile and increased antioxidant capacity in naturally postmenopausal women.
Q38778638Defeating Alzheimer's disease and other dementias: a priority for European science and society
Q33206399Dementia / Alzheimer's Disease
Q33924014Dementia and cognitive impairment: epidemiology, diagnosis, and treatment
Q37263684Dementia prevention: methodological explanations for inconsistent results
Q36787352Dementia syndromes: evaluation and treatment
Q57725293Dementia: new projections and time for an updated response
Q48930833Depressive symptoms and incidence of mild cognitive impairment and probable dementia in elderly women: the Women's Health Initiative Memory Study
Q35028141Depressive symptoms, brain volumes and subclinical cerebrovascular disease in postmenopausal women: the Women's Health Initiative MRI Study
Q30352600Description of an Audio-Based Paced Respiration Intervention for Vasomotor Symptoms.
Q37171151Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies
Q35850280Development of the CHARIOT Research Register for the Prevention of Alzheimer's Dementia and Other Late Onset Neurodegenerative Diseases
Q30374316Device-guided slow-paced respiration for menopausal hot flushes: a randomized controlled trial.
Q89723747Devising a new dialogue for nutrition science: how life course perspective, U-shaped thinking, whole organism thinking, and language precision contribute to our understanding of biological heterogeneity and forge a fresh advance toward precision med
Q36585264Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia
Q34089759Diagnostic Tests for Alzheimer's Disease: Rationale, Methodology, and Challenges
Q22252600Diet and Alzheimer’s disease
Q43196397Diet and the risk for Alzheimer's disease
Q45841349Differences Between Gynecologists and Primary Care Physicians in Hormone Therapy Prescribing: Why They Matter
Q34494238Differences in regional brain metabolism associated with specific formulations of hormone therapy in postmenopausal women at risk for AD.
Q31055402Differential aging of the brain: patterns, cognitive correlates and modifiers
Q37665855Differential contribution of APP metabolites to early cognitive deficits in a TgCRND8 mouse model of Alzheimer's disease
Q35112139Differential effects of dopamine receptor D1-type and D2-type antagonists and phase of the estrous cycle on social learning of food preferences, feeding, and social interactions in mice.
Q46899482Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice
Q37143947Differential effects on visual and spatial recognition memory of a novel hormone therapy regimen of estrogen alone or combined with progesterone in older surgically menopausal monkeys
Q28577277Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis
Q36656437Disease-modifying therapies in Alzheimer's disease: how far have we come?
Q36441754Dismembering the ethical physician
Q35812383Distinct cognitive effects of estrogen and progesterone in menopausal women
Q35918601Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling
Q37100148Does lifetime exposure to hormones predict pretreatment cognitive function in women before adjuvant therapy for breast cancer?
Q49841666Does phytoestrogen supplementation improve cognition in humans? A systematic review
Q46440950Does raloxifene treatment influence back pain and disability among postmenopausal women with osteoporosis?
Q37157784Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice
Q33915170Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits
Q35827072Dramatic change in prescribing of hormone replacement therapy in The Netherlands after publication of the Million Women Study: a follow-up study
Q36826910Driving with Mild Cognitive Impairment or Dementia: Cognitive Test Performance and Proxy Report of Daily Life Function in Older Women
Q21091197Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists
Q34320568Duration of estrogen deprivation, not chronological age, prevents estrogen's ability to enhance hippocampal synaptic physiology
Q36063538Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence
Q35498087Early initiation of hormone therapy in menopausal women is associated with increased hippocampal and posterior cingulate cholinergic activity
Q33981652Early menopausal hormone use influences brain regions used for visual working memory
Q50738168Effect of estrogen and testosterone replacement therapy on cognitive fatigue.
Q36123416Effect of estrogen-serotonin interactions on mood and cognition
Q50437088Effect of tibolone on audiologic functions in menopausal women
Q36684570Effects of Hormone Therapy on Brain Volumes Changes of Postmenopausal Women Revealed by Optimally-Discriminative Voxel-Based Morphometry
Q28547748Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS-Cognitive and Affective Study
Q37482736Effects of aromatase inhibition on bone mineral density and bone turnover in older men with low testosterone levels.
Q37417437Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy
Q42459286Effects of estrogen replacement therapy on cholinergic basal forebrain neurons and cortical cholinergic innervation in young and aged ovariectomized rhesus monkeys
Q26865143Effects of hormone therapy on cognition and mood
Q58726869Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation
Q31112372Effects of long-term testosterone administration on cognition in older men with low or low-to-normal testosterone concentrations: a prespecified secondary analysis of data from the randomised, double-blind, placebo-controlled TEAAM trial
Q33889042Effects of long-term treatment with 17 beta-estradiol and medroxyprogesterone acetate on water maze performance in middle aged female rats
Q36066982Effects of long-term treatment with estrogen and medroxyprogesterone acetate on synapse number in the medial prefrontal cortex of aged female rats
Q48100705Effects of long-term, low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes.
Q44898010Effects of raloxifene, one of the selective estrogen receptor modulators, on pituitary-ovary axis and prolactin in postmenopausal women.
Q41442478Effects of synaptic plasticity regulated by 17beta-estradiol on learning and memory in rats with Alzheimer's disease
Q50921356Effects of testosterone on cognition and mood in male patients with mild Alzheimer's disease and elderly men.
Q43286294Effects of the LHRH antagonist Cetrorelix on affective and cognitive functions in rats
Q46046661Effects of the LHRH antagonist Cetrorelix on the brain function in mice
Q36739764Effects of two estradiol regimens on anxiety and depressive behaviors and trophic effects in peripheral tissues in a rodent model
Q37439245Effects of two years of conjugated equine estrogens on cholinergic neurons in young and middle-aged ovariectomized monkeys
Q46864419Efficacy and safety of 17alpha-hydroxyprogesterone caproate in hormone replacement therapy
Q35593989Efficacy and safety of long-term bisphosphonates in postmenopausal osteoporosis
Q28295716Emerging drugs for sarcopenia: age-related muscle wasting
Q36492347Emerging therapeutics for Alzheimer's disease
Q35618922Emerging therapeutics for Alzheimer's disease: an avenue of hope
Q38067477Endocrinology of menopause.
Q37141534Endpoints for trials in Alzheimer's disease: a European task force consensus
Q35876333Enhanced neuroactivation during verbal memory processing in postmenopausal women receiving short-term hormone therapy
Q35915312Enrollment in a brain magnetic resonance study: results from the Women's Health Initiative Memory Study Magnetic Resonance Imaging Study (WHIMS-MRI).
Q34804413Environmental enrichment reduces the mnemonic and neural benefits of estrogen
Q36546512Epidemiological and clinical trials evidence about a preventive role for statins in Alzheimer's disease
Q37947688Epidemiological findings of vascular risk factors in Alzheimer's disease: implications for therapeutic and preventive intervention
Q40069328Epidemiology of estrogen and dementia in women with Down syndrome
Q37195414Escitalopram reduces hot flashes in nondepressed menopausal women: A pilot study
Q45270702Estradiol and cognition during androgen deprivation in men with prostate carcinoma
Q35054370Estradiol and cognitive function: past, present and future
Q37484251Estradiol and the relationship between dendritic spines, NR2B containing NMDA receptors, and the magnitude of long-term potentiation at hippocampal CA3-CA1 synapses
Q40626859Estradiol binding to maxi-K channels induces their down-regulation via proteasomal degradation
Q42517451Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice
Q48330937Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors alpha and beta
Q37324561Estradiol enhances sociosexual behavior and can have proliferative effects in ovariectomized rats
Q36732302Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: evidence for the critical period hypothesis
Q33875866Estradiol replacement extends the window of opportunity for hippocampal function
Q36748785Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks
Q34482256Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse
Q37136803Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus
Q34481021Estrogen action in mood and neurodegenerative disorders: estrogenic compounds with selective properties-the next generation of therapeutics
Q42491540Estrogen alters spine number and morphology in prefrontal cortex of aged female rhesus monkeys.
Q33649188Estrogen and Progesterone Replacement Therapy Prevent Methamphetamine-Induced Synaptic Plasticity Impairment in Ovariectomized Rats
Q27025613Estrogen and cognitive functioning in women: lessons we have learned
Q48192809Estrogen and dementia: it's a long way from the rat to the randomized clinical trial
Q33644111Estrogen and hippocampal plasticity in rodent models
Q36039975Estrogen and memory in women: how can we reconcile the findings?
Q46207103Estrogen and performance in recognition memory for olfactory and visual stimuli in females diagnosed with Alzheimer's disease
Q33924621Estrogen and the prefrontal cortex: towards a new understanding of estrogen's effects on executive functions in the menopause transition
Q34784469Estrogen anti-inflammatory activity in brain: a therapeutic opportunity for menopause and neurodegenerative diseases
Q33595388Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation
Q44697391Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain
Q35785178Estrogen neuroprotection and the critical period hypothesis
Q48488958Estrogen receptor alpha and APOEepsilon4 polymorphisms interact to increase risk for sporadic AD in Italian females
Q53270093Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women.
Q36322578Estrogen receptor β in Alzheimer's disease: From mechanisms to therapeutics
Q36876459Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1
Q37241063Estrogen regulation of Dkk1 and Wnt/β-Catenin signaling in neurodegenerative disease
Q34360055Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease
Q37675866Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer's disease
Q46058009Estrogen replacement therapy, Alzheimer's disease, and mild cognitive impairment
Q21284766Estrogen signaling and the aging brain: context-dependent considerations for postmenopausal hormone therapy
Q92042117Estrogen sulfotransferase in the metabolism of estrogenic drugs and in the pathogenesis of diseases
Q36677805Estrogen synthesis and signaling pathways during aging: from periphery to brain
Q48335998Estrogen therapy and brain muscarinic receptor density in healthy females: a SPET study
Q33779694Estrogen therapy and cognition: a review of the cholinergic hypothesis
Q46947447Estrogen treatment effects on anticholinergic-induced cognitive dysfunction in normal postmenopausal women
Q50720565Estrogen treatment effects on cognition, memory and mood in male-to-female transsexuals.
Q99345086Estrogen, brain structure, and cognition in postmenopausal women
Q34585797Estrogen, cognition and female ageing
Q36621171Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women.
Q24805637Estrogen, progesterone and epithelial ovarian cancer
Q35690176Estrogen-BDNF interactions: implications for neurodegenerative diseases.
Q33677902Estrogen-Related Factors in the Frontal Lobe of Alzheimer's Disease Patients and Importance of Body Mass Index
Q26799402Estrogen-cholinergic interactions: Implications for cognitive aging
Q53266049Estrogen-metabolizing gene COMT polymorphism synergistic APOE epsilon4 allele increases the risk of Alzheimer disease.
Q33623924Estrogen: a master regulator of bioenergetic systems in the brain and body
Q28079898Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases
Q37147787Estrogens and age-related memory decline in rodents: what have we learned and where do we go from here?
Q34483748Estrogens and cognition: Friends or foes?: An evaluation of the opposing effects of estrogens on learning and memory
Q36980880Estrogens and progesterone as neuroprotectants: what animal models teach us
Q38739583Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury
Q83753613Estrogens need insulin-like growth factor I cooperation to exert their neuroprotective effects in post-menopausal women
Q36931711Estrogens, episodic memory, and Alzheimer's disease: a critical update
Q34269755Estrogens, estrogen receptors, and female cognitive aging: the impact of timing
Q26771644Estrogens, inflammation and cognition
Q24612411European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Q37037296European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Q57465255European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Q38814359Evaluating the Role of Hormone Therapy in Postmenopausal Women with Alzheimer's Disease
Q37007979Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms
Q80443430Evidence-based medicine and hormone replacement therapy
Q37724078Evolution of Quantitative Measures in NMR: Quantum Mechanical qHNMR Advances Chemical Standardization of a Red Clover (Trifolium pratense) Extract.
Q35615125Evolutionary rather than revolutionary progress in dementia
Q50600187Executive functions in men and postmenopausal women.
Q35682935Exercise and estrogen or estrogen alternatives (phytoestrogens, bisphosphonates)for preservation of bone mineral in postmenopausal women
Q33357034Experiences of a long-term randomized controlled prevention trial in a maiden environment: Estonian Postmenopausal Hormone Therapy trial
Q49586649FSH to estradiol ratio can be used as screening method for mild cognitive impairment in postmenopausal women
Q36901959Factors influencing the cognitive and neural effects of hormone treatment during aging in a rodent model
Q37090625Familial Alzheimer disease in Latinos: interaction between APOE, stroke, and estrogen replacement
Q57301587Female Sex and Alzheimer's Risk: The Menopause Connection
Q33756791Female reproductive factors, menopausal hormone use, and Parkinson's disease
Q35034379Folate, vitamin B-6, and vitamin B-12 intake and mild cognitive impairment and probable dementia in the Women's Health Initiative Memory Study.
Q37324566Frontiers proposal. National Institute on Aging "bench to bedside: estrogen as a case study".
Q37605837GABA+ levels in postmenopausal women with mild-to-moderate depression: A preliminary study
Q92543481GABA-A receptor modulating steroids in acute and chronic stress; relevance for cognition and dementia?
Q34612871GPR30 is positioned to mediate estrogen effects on basal forebrain cholinergic neurons and cognitive performance
Q35534146Galanthamine plus estradiol treatment enhances cognitive performance in aged ovariectomized rats
Q26828629Gaps in menopause knowledge
Q92542344Gender Difference in the Effects of Outdoor Air Pollution on Cognitive Function Among Elderly in Korea
Q38225583Gender and cataract--the role of estrogen
Q48382481Gender dependent APP processing in a transgenic mouse model of Alzheimer's disease
Q36914115Gender differences in dementia risk factors
Q36146996Gender, sex steroid hormones, and Alzheimer's disease.
Q33427814Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease
Q42363857Genetic Analysis of Mitochondrial Ribosomal Proteins and Cognitive Aging in Postmenopausal Women
Q37795699Genetic variability in estrogen disposition: Potential clinical implications for neuropsychiatric disorders
Q40822236Genetically predicted 17beta-estradiol, cognitive function and depressive symptoms in women: A Mendelian randomization in the Guangzhou Biobank Cohort Study.
Q36248069Genistein protects against Aβ25-35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers
Q37028001Global cognitive function before, surrounding, and after ischemic stroke: the role of risk and protective factors varies with time among ischemic stroke survivors
Q36909207Gonadal hormones and cognitive aging: a midlife perspective
Q34673793Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline
Q22306361Guidelines for the Prevention of Stroke in Women: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
Q36408852Guidelines for the treatment of Alzheimer's disease from the Italian Association of Psychogeriatrics
Q35539421HRT: Decide Based on the Evidence
Q35563932HT and CVD prevention. from myth to reality
Q50431361Hearing levels in menopausal women and the effect of tibolone on audiological functions.
Q26740203Herbal Medicine for Hot Flushes Induced by Endocrine Therapy in Women with Breast Cancer: A Systematic Review and Meta-Analysis
Q35787891High levels of estrogen enhance associative memory formation in ovariectomized females
Q37567503Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study
Q36755714Higher levels of estradiol replacement correlate with better spatial memory in surgically menopausal young and middle-aged rats
Q34680911Hormonal influences on cognition and risk for Alzheimer's disease
Q37029421Hormonal treatment, mild cognitive impairment and Alzheimer's disease
Q57466987Hormone Replacement Therapy: Would it be Possible to Replicate a Functional Ovary?
Q37115589Hormone effects on fMRI and cognitive measures of encoding: importance of hormone preparation
Q35884815Hormone replacement therapy and risk for neurodegenerative diseases.
Q24242542Hormone replacement therapy for cognitive function in postmenopausal women
Q33554786Hormone replacement therapy for the primary prevention of chronic diseases: recommendation statement from the Canadian Task Force on Preventive Health Care
Q35622642Hormone replacement therapy in climacteric and aging brain
Q36668526Hormone replacement therapy in menopausal women: Past problems and future possibilities
Q35966781Hormone replacement therapy in women with spinal cord injury - a survey with literature review
Q24241789Hormone replacement therapy to maintain cognitive function in women with dementia
Q36475295Hormone therapy and Alzheimer disease dementia: new findings from the Cache County Study.
Q35680612Hormone therapy and Alzheimer's disease: benefit or harm?
Q37381044Hormone therapy and cognitive function
Q36051186Hormone therapy and risk for dementia: where do we go from here?
Q37713006Hormone therapy at early post-menopause increases cognitive control-related prefrontal activity
Q24202201Hormone therapy for sexual function in perimenopausal and postmenopausal women
Q36459544Hormone therapy in the WHI era.
Q36887336Hormone therapy, dementia, and cognition: the Women's Health Initiative 10 years on.
Q38975101Hormone-replacement therapy: current thinking
Q37165598Hormones and dementia - a comparative study of hormonal impairment in post-menopausal women, with and without dementia
Q36362593Hormones and menopause: pro.
Q35631823Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction.
Q37036997Human chorionic gonadotropin (a luteinizing hormone homologue) decreases spatial memory and increases brain amyloid-beta levels in female rats.
Q35876440Hypertension and dementia: does blood pressure control favorably affect cognition?
Q36492399Hypertension, Dietary Sodium, and Cognitive Decline: Results From the Women's Health Initiative Memory Study
Q36528233Hypothalamic-pituitary-gonadal axis homeostasis predicts longevity
Q37594833Identification of a predictive biomarker for the beneficial effect of keishibukuryogan, a kampo (Japanese traditional) medicine, on patients with climacteric syndrome.
Q34516562Identifying botanical mechanisms of action
Q46375945Identifying target regions for vigilance improvement under hormone replacement therapy in postmenopausal syndrome patients by means of electroencephalographic tomography (LORETA).
Q36311674Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women
Q50849905Impact of a premature menopause on cognitive function in later life.
Q33827647Impact of atomoxetine on subjective attention and memory difficulties in perimenopausal and postmenopausal women
Q35774584Impact of combined estradiol and norethindrone therapy on visuospatial working memory assessed by functional magnetic resonance imaging
Q35771516Impact of estrogen therapy on Alzheimer's disease: a fork in the road?
Q36372962Impact of risk-reducing salpingo-oophorectomy in premenopausal women
Q52343348Impact of sex steroids and reproductive stage on sleep-dependent memory consolidation in women.
Q37764494Impact of the hypothalamic-pituitary-adrenal/gonadal axes on trajectory of age-related cognitive decline
Q37125488Impaired cognition and attention in adults: pharmacological management strategies
Q46526541Implications of statin adverse effects in the elderly
Q34316296Increased memory load-related frontal activation after estradiol treatment in postmenopausal women
Q57816569Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer's Disease
Q37812784Inhibition of estrogen actions in human gynecological malignancies: New aspects of endocrine therapy for endometrial cancer and ovarian cancer
Q28482218Insulinotropic effect of the non-steroidal compound STX in pancreatic β-cells
Q28394967Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors
Q35194607Interactive effects of age and estrogen on cortical neurons: implications for cognitive aging
Q34206248Interactive effects of estrogen and serotonin on brain activation during working memory and affective processing in menopausal women
Q37436161Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia
Q24802767Introducing a new section to Breast Cancer Research: Endocrinology and hormone therapy
Q35579234Investigational drugs for the treatment of AD: what can we learn from negative trials?
Q48614782Involvement of Luteinizing Hormone in Alzheimer Disease Development in Elderly Women
Q81002469Is the WHI relevant to HRT started in the perimenopause?
Q37018510Is timing everything? New insights into why the effect of estrogen therapy on memory might be age dependent
Q36238850Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis
Q34978861Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model
Q33854590Lack of association of acute phase response proteins with hormone levels and antidepressant medication in perimenopausal depression
Q35095659Language performance in postmenopausal women with and without hormone therapy and men.
Q36176198Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice.
Q46583975Lifecourse social conditions and racial and ethnic patterns of cognitive aging
Q36375568Lifestyle Activities in Sociodemographically at-risk Urban, Older Adults Prior to Participation in the Baltimore Experience Corps(®) Trial
Q90716417Lifetime estrogen exposure and cognition in late life: the Cache County Study
Q35637145Ligand-modified aminobisphosphonate for linking proteins to hydroxyapatite and bone surface.
Q35748577Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid.
Q24647962Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist
Q24201974Long term hormone therapy for perimenopausal and postmenopausal women
Q24241279Long term hormone therapy for perimenopausal and postmenopausal women
Q24246577Long term hormone therapy for perimenopausal and postmenopausal women
Q35616166Long-term consequences of estrogens administered in midlife on female cognitive aging
Q37277562Long-term effects of bilateral oophorectomy on brain aging: unanswered questions from the Mayo Clinic Cohort Study of Oophorectomy and Aging
Q34048789Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women's Health Initiative study of cognitive aging extension
Q36672688Long-term estrogen deprivation leads to elevation of Dickkopf-1 and dysregulation of Wnt/β-Catenin signaling in hippocampal CA1 neurons
Q30238978Long-term hormone therapy for perimenopausal and postmenopausal women
Q35718091Long-term replacement of estrogen in combination with medroxyprogesterone acetate improves acquisition of an alternation task in middle-aged female rats
Q38041758Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial
Q41102759Long-term use of tamoxifen reduces the risk of dementia: a nationwide population-based cohort study
Q37000444Longitudinal Cognitive Trajectories of Women Veterans from the Women's Health Initiative Memory Study
Q92648681Low-fat dietary pattern and global cognitive function: Exploratory analyses of the Women's Health Initiative (WHI) randomized Dietary Modification trial
Q57492371Luteinizing Hormone Involvement in Aging Female Cognition: Not All Is Estrogen Loss
Q38510860Luteinizing hormone as a key player in the cognitive decline of Alzheimer's disease
Q58485914Maintaining cognitive health in elderly women
Q92403062Making DEEP Sense of Lifestyle Risk and Resilience
Q39027923Management of Depression in Patients with Dementia: Is Pharmacological Treatment Justified?
Q37477055Management of patients with mild cognitive impairment and mild to moderate dementia
Q88676389Managing Menopause by Combining Evidence With Clinical Judgment
Q35742248Managing the menopause.
Q37245953Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens
Q33436267Mechanisms of action of estrogen in the brain: insights from human neuroimaging and psychopharmacologic studies
Q38061846Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks.
Q37048086Medical management of frontotemporal dementia
Q22242806Medications and Diet
Q92132021Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner
Q35168390Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function
Q30465714Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats.
Q43169451Melatonin modulates hippocampus NMDA receptors, blood and brain oxidative stress levels in ovariectomized rats
Q38471641Membrane-initiated signaling of estrogen related to neuroprotection. "Social networks" are required
Q40045531Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women's Health Initiative Randomized Trials
Q36152764Menopausal hormone therapy
Q76318144Menopausal hormone therapy after breast cancer
Q37658616Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials
Q44200265Menopausal hormone therapy for cardiovascular protection--unfulfilled expectations
Q79227448Menopausal hormone therapy informed consent
Q33644735Menopausal hormone therapy: a systematic review of cost-effectiveness evaluations
Q36078563Menopausal hormone therapy: is there evidence for cardiac protection?.
Q48441036Menopausal symptom perception and severity: results from a screening questionnaire
Q37822795Menopause and mental well-being: timing of symptoms and timing of hormone treatment
Q43028519Menopause and mitochondria: windows into estrogen effects on Alzheimer's disease risk and therapy
Q37144896Menopause, estrogen, and gonadotropins in Alzheimer's disease
Q21131065Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease
Q37030684Menopause: developing a rational treatment plan
Q40238961Meta-analyses of the effect of hormone treatment on cognitive function in postmenopausal women.
Q36302335Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology
Q26994975Mild cognitive impairment and dementia: the importance of modifiable risk factors
Q35194758Mild cognitive impairment clinical trials
Q37047850Mild cognitive impairment prevention: diet, sports and treatment approaches.
Q36036755Mnemonic effects of progesterone to mice require formation of 3alpha,5alpha-THP.
Q34496551Modeling hot flushes and quality of life in breast cancer survivors
Q28392016Modeling menopause: The utility of rodents in translational behavioral endocrinology research
Q37436616Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia
Q40006640Morphine protects against intracellular amyloid toxicity by inducing estradiol release and upregulation of Hsp70.
Q36756290Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys
Q37502104Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons.
Q36511912Multiple pathways transmit neuroprotective effects of gonadal steroids
Q35206981NSAIDs and Alzheimer's disease: how far to generalise from trials?
Q33242024Natural health products in the prevention and treatment of osteoporosis: systematic review of randomized controlled trials
Q43227534Natural hormone therapy for menopause
Q36817040Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?
Q38005895Neuroprotection and estrogen receptors
Q37479919Neuroprotective actions of selective estrogen receptor modulators.
Q33762953Neuroprotective effects of estrogen therapy for cognitive and neurobiological profiles of monkey models of menopause
Q38530418Neuroprotective effects of estrogens: the role of cholesterol
Q48298260Neuroscience: it's all in the timing
Q35078498Neuroscientists as cartographers: mapping the crossroads of gonadal hormones, memory and age using animal models
Q57817974Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease
Q35971833Neurosteroids and GABA-A Receptor Function
Q90077292Neurosteroids as regulators of neuroinflammation
Q24618586Neurosteroids' effects and mechanisms for social, cognitive, emotional, and physical functions
Q48878246Neurotherapeutic Effects of Pueraria mirifica Extract in Early- and Late-Stage Cognitive Impaired Rats
Q36102771Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications
Q35948672New HRT options for the treatment of menopausal symptoms and the maintenance of quality of life in postmenopausal women
Q38027193New generation nonhormonal management for hot flashes
Q36939490New hormonal therapies and regimens in the postmenopause: routes of administration and timing of initiation
Q37436652New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm
Q34551983New progestogens: a review of their effects in perimenopausal and postmenopausal women
Q46407690New thoughts about estrogen therapy from the Women's Health Initiative
Q31070019No Association between Dietary Patterns and Risk for Cognitive Decline in Older Women with 9-Year Follow-Up: Data from the Women's Health Initiative Memory Study
Q45239413No changes in event-related potentials with estrogen or estrogen plus progesterone treatment in healthy older hysterectomized women: results from a double-blind, placebo-controlled study
Q24246936Non-hormonal therapy for hot flushes in postmenopausal women
Q57341506Nonestrogen-based hormonal therapies for Alzheimer’s disease
Q34411638Normal genetic variation, cognition, and aging
Q36459049Novel mechanisms for estrogen-induced neuroprotection
Q35579936Nutritional Approaches to Late Toxicities of Adjuvant Chemotherapy in Breast Cancer Survivors
Q33694232Oestradiol modulation of cognition in adult female marmosets (Callithrix jacchus).
Q37285879Oestrogen receptor alpha localisation in the prefrontal cortex of three mammalian species
Q35882885Oestrogen signalling and neuroprotection in cerebral ischaemia
Q33677382Omega-3 fatty acids and cognitive function in women
Q40519882On the horizon: pathways for drug development in Alzheimer's disease
Q44591310Onset of estrogen replacement has a critical effect on synaptic density of CA1 hippocampus in ovariectomized adult rats
Q26853730Oophorectomy, estrogen, and dementia: a 2014 update
Q34612492Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity
Q33808780Oophorectomy, menopause, estrogen, and cognitive aging: the timing hypothesis
Q38169998Oral contraceptives and nicotine synergistically exacerbate cerebral ischemic injury in the female brain
Q60954733Ovarian Cycle Stages Modulate Alzheimer-Related Cognitive and Brain Network Alterations in Female Mice
Q35235439Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid
Q58738244Ovarian survival after pelvic radiation: transposition until the age of 35 years
Q37244609Ovariectomy and 17beta-estradiol replacement do not alter beta-amyloid levels in sheep brain
Q46511765Ovariectomy enhances acetylcholinesterase activity but does not alter ganglioside content in cerebral cortex of female adult rats.
Q46467674Ovariectomy impairs spatial memory: prevention and reversal by a soy isoflavone diet.
Q35643128Perceived control and hot flashes in treatment-seeking breast cancer survivors and menopausal women
Q33206403Perimenopausal and Postmenopausal Health
Q38218301Periodic Estrogen Receptor-Beta Activation: A Novel Approach to Prevent Ischemic Brain Damage
Q37198579Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately?
Q35957574Pharmacotherapeutic approaches to the prevention of Alzheimer's disease
Q47562258Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health
Q43154107Post hoc magnetic resonance imaging cannot justify the conclusions of WHIMS.
Q42840295Postmenopausal hormone therapy
Q37742148Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study
Q27008086Postmenopausal hormone therapy and cognition
Q33516441Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS).
Q37180441Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study
Q37180460Postmenopausal hormone therapy and subclinical cerebrovascular disease: the WHIMS-MRI Study
Q34420014Postmenopausal hormone therapy and the risks of coronary heart disease, breast cancer, and stroke
Q37416371Postmenopausal hormone therapy is not associated with risk of all-cause dementia and Alzheimer's disease
Q36355137Postmenopausal hormone therapy, timing of initiation, APOE and cognitive decline
Q35692889Postmenopausal hormone therapy: a concise guide to therapeutic uses, formulations, risks, and alternatives
Q30451123Postmenopausal hormone therapy: an Endocrine Society scientific statement.
Q35732023Postmenopausal hormone therapy: impact on menopause-related symptoms, chronic disease and quality of life
Q53350994Postmenopausal hormone therapy: the pros and cons.
Q26795412Postmenopausal syndrome
Q35538824Potential Use of Estrogen-Like Drugs for the Prevention of Alzheimer's Disease
Q34720369Potential mechanisms of estrogen quinone carcinogenesis
Q37418919Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease.
Q34312062Predicting Alzheimer's disease in the Baltimore longitudinal study of aging
Q43673343Pregnancy history and cognition during and after pregnancy.
Q37417828Premarin improves memory, prevents scopolamine-induced amnesia and increases number of basal forebrain choline acetyltransferase positive cells in middle-aged surgically menopausal rats
Q33278956Premature ovarian failure: a review
Q27022920Prescribing menopausal hormone therapy: an evidence-based approach
Q36876447Present and prospective clinical therapeutic regimens for Alzheimer's disease
Q51984926Prevalence of memory loss complaints and other symptoms associated with the menopause transition: a community survey.
Q34847609Preventing Alzheimer's disease : separating fact from fiction
Q37001410Preventing cognitive decline in healthy older adults
Q38719665Prevention Trials in Alzheimer's Disease: Current Status and Future Perspectives
Q22248031Prevention of Alzheimer's disease
Q53499870Prevention of Alzheimer's disease, cerebrovascular disease and dementia in women: the case for menopause hormone therapy.
Q38223587Prevention of diseases after menopause.
Q38554910Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions
Q38983318Prevention studies in Alzheimer's disease: progress towards the development of new therapeutics
Q36616443Prevention, Rehabilitation, and Mitigation Strategies of Cognitive Deficits in Aging with HIV: Implications for Practice and Research
Q37670673Primary and Secondary Prevention Trials in Alzheimer Disease: Looking Back, Moving Forward
Q36806653Primary prevention and delay of onset of AD/dementia
Q44336092Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice.
Q48171447Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor
Q37072797Progesterone influence on neurite outgrowth involves microglia.
Q37220808Progesterone reduces depression-like behavior in a murine model of Alzheimer's Disease
Q30053198Progestin negatively affects hearing in aged women
Q39943537Progestogens influence cognitive processes in aging
Q34317537Progestogens used in postmenopausal hormone therapy: differences in their pharmacological properties, intracellular actions, and clinical effects
Q37175385Progestogens' effects and mechanisms for object recognition memory across the lifespan
Q36436653Prognostic factors in paediatric anaplastic large cell lymphoma: role of ALK.
Q33772525Promotion of cognitive health through cognitive activity in the aging population
Q35119064Prospective randomized trial to assess effects of continuing hormone therapy on cerebral function in postmenopausal women at risk for dementia
Q37309638Protective actions of sex steroid hormones in Alzheimer's disease
Q36972735Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection
Q37261100Provider attributes associated with hormone therapy prescribing frequency
Q47420424Pueraria lobate Inhibits RANKL-Mediated Osteoclastogenesis Via Downregulation of CREB/PGC1β/c-Fos/NFATc1 Signaling
Q35707934Quinoids formed from estrogens and antiestrogens
Q37063691Rationale and design of the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS Cognitive and Affective sub study (KEEPS Cog)
Q22242395Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline
Q38002365Recruitment methods for United States Alzheimer disease prevention trials
Q34604092Reducing case ascertainment costs in U.S. population studies of Alzheimer's disease, dementia, and cognitive impairment-Part 1
Q28583938Regulation of Cytokine-Induced Neuron Death by Ovarian Hormones: Involvement of Antiapoptotic Protein Expression and c-JUN N-Terminal Kinase-Mediated Proapoptotic Signaling
Q48922535Regulation of synaptic plasticity by hippocampus synthesized estradiol
Q36691761Relationship between estrogen and schizophrenia
Q54308569Relationship between the neuroprotective effects of insulin-like growth factor-1 and 17β-oestradiol in human neuroblasts.
Q33831158Relationship of hypertension, blood pressure, and blood pressure control with white matter abnormalities in the Women's Health Initiative Memory Study (WHIMS)-MRI trial
Q39767296Reorganization of Functional Networks in Verbal Working Memory Circuitry in Early Midlife: The Impact of Sex and Menopausal Status
Q51533934Reporting on post-menopausal hormone therapy: an analysis of gynaecologists' web pages.
Q30451655Reproductive aging, menopause, and health outcomes
Q33820067Reproductive aging, sex steroids, and mood disorders
Q89951553Reproductive and hormonal factors and risk of cognitive impairment among Singapore Chinese women
Q36328001Response to dr simes and dr snabes
Q56031122Review of the effects of 17α-estradiol in humans: a less feminizing estrogen with neuroprotective potential
Q28262783Risk factors for dementia
Q24647700Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence
Q36019567Role of progestins with partial antiandrogenic effects
Q46633788Role of protein phosphatases in estrogen-mediated neuroprotection.
Q24625569Roles for oestrogen receptor β in adult brain function
Q64063020Royal Jelly Ameliorates Behavioral Deficits, Cholinergic System Deficiency, and Autonomic Nervous Dysfunction in Ovariectomized Cholesterol-Fed Rabbits
Q36794420SERMs for the treatment and prevention of breast cancer
Q38700757Safety and benefit considerations for menopausal hormone therapy
Q34362281Scientific rationale for postmenopause delay in the use of conjugated equine estrogens among postmenopausal women that causes reduction in breast cancer incidence and mortality
Q33236269Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disea
Q35721863Selective estrogen receptor modulation: concept and consequences in cancer
Q35569533Selective estrogen receptor modulators (SERMs) enhance neurogenesis and spine density following focal cerebral ischemia
Q38808173Serum SHBG Levels are not Associated with Longitudinal Cognitive Decline in Mild Cognitive Impairment
Q40281627Serum phosphate and cognitive function in older men.
Q47836220Sex Hormones and Healthy Psychological Aging in Women.
Q91706991Sex and Gender Driven Modifiers of Alzheimer's: The Role for Estrogenic Control Across Age, Race, Medical, and Lifestyle Risks
Q34214272Sex and gender differences in the causes of dementia: a narrative review
Q36473640Sex and gonadal hormones in mouse models of Alzheimer's disease: what is relevant to the human condition?
Q50506777Sex and post-menopause hormone therapy effects on hippocampal volume and verbal memory.
Q37432182Sex and the development of Alzheimer's disease.
Q48617816Sex differences in Alzheimer's disease risk: are we looking at the wrong hormones?
Q33864547Sex differences in cognitive impairment and Alzheimer's disease
Q82035418Sex differences in stroke
Q35103802Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods
Q46221971Sex steroid hormones and brain function: PET imaging as a tool for research
Q38119012Sex, hormones and neurogenesis in the hippocampus: hormonal modulation of neurogenesis and potential functional implications
Q36176965Sex, hormones, and Alzheimer's disease
Q49601287Sex-related differences in oxidative stress and neurodegeneration
Q64089258Sexual Function and Factors Affecting Menopause: A Systematic Review
Q35083240Sexual dimorphism in ischemic stroke: lessons from the laboratory
Q57143986Sexual dimorphism in predisposition to Alzheimer's disease
Q35015991Sharing clinical decisions by discussing evidence with patients
Q46342146Short-term effects of treatment-induced hormonal changes on cognitive function in breast cancer patients: results of a multicenter, prospective, longitudinal study
Q36024730Single and multiple ascending dose studies of a novel tissue-selective oestrogen receptor modulator, CHF 4227, in healthy postmenopausal women
Q33267870Skin and menopause
Q36373516Sleep duration, cognitive decline, and dementia risk in older women
Q44799141Spatial memory retention is enhanced by acute and continuous estradiol replacement
Q36084087Standards of Evidence for Efficacy, Effectiveness, and Scale-up Research in Prevention Science: Next Generation
Q40363847Standards of evidence: criteria for efficacy, effectiveness and dissemination
Q24603957Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism
Q46011754Statin-associated adverse cognitive effects: survey results from 171 patients.
Q55333269Steroid Hormones and Their Action in Women's Brains: The Importance of Hormonal Balance.
Q35070362Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease
Q39432214Strategies for Preventing Cognitive Decline in Healthy Older Adults
Q37714345Stroke in women
Q35867501Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds
Q33462283Subcortical ischemic cerebrovascular dementia
Q34088579Subtypes of mild cognitive impairment in older postmenopausal women: the Women's Health Initiative Memory Study
Q43424580Sugary foods and gynecological cancer risk
Q35765716Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease
Q58582917Synaptic distributions of pS214-tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline
Q38840921Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases.
Q35016901Targeting gonadotropins: an alternative option for Alzheimer disease treatment
Q44852721Testosterone and the brain: uncharted territory
Q24248598Testosterone for peri- and postmenopausal women
Q34161400The 2012 hormone therapy position statement of: The North American Menopause Society
Q58614226The Association Between Body Mass Index, and Cognitive, Functional, and Behavioral Declines for Incident Dementia
Q33873941The Cache County Study on Memory in Aging: factors affecting risk of Alzheimer's disease and its progression after onset
Q90637954The Effect of Estrogen Replacement Therapy on Alzheimer's Disease and Parkinson's Disease in Postmenopausal Women: A Meta-Analysis
Q33716695The Effect of Luteinizing Hormone Reducing Agent on Anxiety and Novel Object Recognition Memory in Gonadectomized Rats
Q35952978The GABAA antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats
Q57054214The Middle-Aged Brain: Biological sex and sex hormones shape memory circuitry
Q38927944The Potential of Gonadal Hormone Signalling Pathways as Therapeutics for Dementia.
Q91262891The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial
Q35234851The TU-025 keishibukuryogan clinical trial for hot flash management in postmenopausal women: results and lessons for future research
Q38602074The Utility of the Cognitive Function Instrument (CFI) to Detect Cognitive Decline in Non-Demented Older Adults.
Q46797789The Women's Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline
Q36103525The Women's Health Initiative study: perspectives and implications for clinical practice
Q36668062The ageing cortical synapse: hallmarks and implications for cognitive decline
Q35444823The allelic modulation of apolipoprotein E expression by oestrogen: potential relevance for Alzheimer's disease
Q40190946The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study.
Q88636986The borderland between normal aging and dementia
Q22299214The breast cancer epidemic: 10 facts
Q30496612The cognitive effects of conjugated equine estrogens depend on whether menopause etiology is transitional or surgical
Q36203397The contribution of luteinizing hormone to Alzheimer disease pathogenesis
Q36704008The critical period hypothesis: can it explain discrepancies in the oestrogen-cognition literature?
Q34200495The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the Women's Health Initiative
Q36094647The current state of postmenopausal hormone therapy: update for neurologists and epileptologists
Q37244686The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression
Q37361099The effect of gonadectomy and estradiol on sensitivity to oxidative stress.
Q37172024The effects of acute 17beta-estradiol treatment on gene expression in the young female mouse hippocampus.
Q48130002The effects of chronic estradiol treatment on working memory deficits induced by combined infusion of beta-amyloid (1-42) and ibotenic acid
Q36439357The effects of long-term treatment with estradiol and medroxyprogesterone acetate on tyrosine hydroxylase fibers and neuron number in the medial prefrontal cortex of aged female rats.
Q37975168The hormonal pathway to cognitive impairment in older men.
Q34722892The impact of comorbidities on hormone use. After the 2000 release of the Women's Health Initiative
Q57467639The lifespan Human Connectome Project in aging: An overview
Q36710473The medical management of menopause: a four-country comparison care in urban areas
Q53282854The number of pregnancies is a risk factor for Alzheimer's disease.
Q28263673The potential for estrogens in preventing Alzheimer's disease and vascular dementia
Q37725622The pregnane xenobiotic receptor, a prominent liver factor, has actions in the midbrain for neurosteroid synthesis and behavioral/neural plasticity of female rats
Q82715303The prevention of dementia
Q25257485The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells
Q36933312The rationale, design, and baseline characteristics of the Women's Health Initiative Memory Study of Younger Women (WHIMS-Y).
Q33290019The role of adolescent IQ and gender in the use of cognitive support for remembering in aging
Q36511930The role of gonadotropins in Alzheimer's disease: potential neurodegenerative mechanisms.
Q37145381The role of hormone therapy and calcium plus vitamin D for reduction of bone loss and risk for fractures: lessons learned from the Women's Health Initiative
Q61799790The role of hydrogen in Alzheimer's disease
Q36577266Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease
Q57341342Thinking Outside the Box in Alzheimer Disease Treatment
Q35544502Thinking globally, acting locally: steroid hormone regulation of the dendritic architecture, synaptic connectivity and death of an individual neuron
Q34536301Three midlife strategies to prevent cognitive impairment due to Alzheimer's disease
Q37223038Thyroid function and the risk of Alzheimer disease: the Framingham Study
Q35191452Time and dose-dependent effects of Labisia pumila on the bone strength of postmenopausal osteoporosis rat model.
Q89308533Timing of cyclic estradiol treatment differentially affects cognition in aged female rhesus monkeys
Q34683673Timing of hormone therapy and dementia: the critical window theory revisited
Q34468841Tonic Premarin dose-dependently enhances memory, affects neurotrophin protein levels and alters gene expression in middle-aged rats.
Q28600847Trajectories and phenotypes with estrogen exposures across the lifespan: What does Goldilocks have to do with it?
Q34684381Translational research on the way to effective therapy for Alzheimer disease
Q36388561Treating vascular risk factors and maintaining vascular health: is this the way towards successful cognitive ageing and preventing cognitive decline?
Q47148252Treatment of Alzheimer's disease in Brazil: I. Cognitive disorders
Q36219667Treatment of menopausal symptoms post-Women's Health Initiative: refinement of existing treatments and development of new therapies
Q36213129Treatment of menopausal symptoms: what shall we do now?
Q35068765Trends in menopausal hormone therapy use of US office-based physicians, 2000-2009
Q36737783Uncovering the mechanisms of estrogen effects on hippocampal function.
Q89119354Understanding the impact of sex and gender in Alzheimer's disease: A call to action
Q51044084Underuse of ovarian transposition in reproductive-aged cancer patients treated by primary or adjuvant pelvic irradiation.
Q35941842Update on the effect of estradiol in postmenopause women with Alzheimer's disease: a systematic review
Q37989179Update: estrogen and estrogen plus progestin therapy in the care of women at and after the menopause
Q46064533Use of compounded bioidentical hormone therapy in menopausal women: an opinion statement of the Women's Health Practice and Research Network of the American College of Clinical Pharmacy
Q36149372Use of hormone replacement therapy by postmenopausal women after publication of the Women's Health Initiative Trial
Q64055802Use of postmenopausal hormone therapy and risk of Alzheimer’s disease in Finland: nationwide case-control study
Q30513312Using predictors of hormone therapy use to model the healthy user bias: how does healthy user status influence cognitive effects of hormone therapy?
Q53365863Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI.
Q36331030Vascular dementia prevention: a risk factor analysis
Q34659256Vascular dementia: a review of recent evidence for prevention and treatment
Q37299896Vascular factors and prevention of dementia.
Q35636070Verbal episodic memory and endogenous estradiol: an association in patients with mild cognitive impairment and Alzheimer's disease
Q33782547Vitamin D insufficiency.
Q50736681Web chatter before and after the Women's Health Initiative results: a content analysis of on-line menopause message boards.
Q40418625Weight Trajectory over 20 Years and Likelihood of Mild Cognitive Impairment or Dementia Among Older Women
Q38034060What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer's disease, about the therapeutic strategies in Alzheimer's research
Q44969204What is the rationale for new treatment strategies in Alzheimer's disease?
Q27021193When Mars Versus Venus is Not a Cliché: Gender Differences in the Neurobiology of Alzheimer's Disease
Q53220661When practices, promises, profits, and policies outpace hard evidence: the post-menopausal hormone debate.
Q36350786Where are we with postmenopausal hormone therapy in 2005?
Q38796711Why estrogens matter for behavior and brain health
Q37252601Women with and without intellectual disability and psychiatric disorders: an examination of the literature
Q57055214Women's Health Initiative: Statistical Aspects and Selected Early Results
Q57055349Women's Health Initiative: Statistical Aspects and Selected Early Results
Q52000029Women's cognitive health: postmenopausal dementia and the women's health initiative memory study.
Q48411484Women's conception of the menopausal transition--a qualitative study
Q79299218Women's health issues
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Q39329106[Menopausal hormone therapy].
Q53282559[New therapeutic approaches in Alzheimer disease].
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Q81591791[Update on menopause treatments, after recent controversies]

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