On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation.

scientific article published in June 2003

On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1194/JLR.M300047-JLR200
P698PubMed publication ID12777473

P50authorMaria NorlinQ39367940
Ingemar BjörkhemQ39908514
P2093author name stringKjell Wikvall
Sara von Bahr
P2860cites workExpression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterolQ22253434
Oxysterol biosynthetic enzymesQ28139744
Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1)Q28214632
A cDNA encoding a rat mitochondrial cytochrome P450 catalyzing both the 26-hydroxylation of cholesterol and 25-hydroxylation of vitamin D3: gonadotropic regulation of the cognate mRNA in ovariesQ28567277
Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathwaysQ28613243
Disruption of the oxysterol 7alpha-hydroxylase gene in mice.Q33896722
Unique property of liver mitochondrial P450 to catalyze the two physiologically important reactions involved in both cholesterol catabolism and vitamin D activationQ41714908
Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A).Q43504787
From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humansQ43681969
Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat.Q45108263
Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27).Q54563410
Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transportQ59307006
Biochemical characterization of the 7α-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomesQ61699140
Omega-hydroxylation of steriod side-chain in biosynthesis of bile acidsQ70039667
P433issue8
P304page(s)1515-1522
P577publication date2003-06-01
P1433published inJournal of Lipid ResearchQ6295449
P1476titleOn the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation
P478volume44

Reverse relations

cites work (P2860)
Q37297846Bile acids as regulatory molecules
Q48407922Cholestanol metabolism in patients with cerebrotendinous xanthomatosis: absorption, turnover, and tissue deposition
Q33713631Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice
Q28487151Functional Redundancy of Steroid C26-monooxygenase Activity in Mycobacterium tuberculosis Revealed by Biochemical and Genetic Analyses
Q41889300High levels of oxysterol sulfates in serum of patients with steroid sulfatase deficiency.
Q57106715Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma
Q51064399Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia.
Q39964767Metabolism of a novel side chain modified Delta8(14)-15-ketosterol, a potential cholesterol lowering drug: 28-hydroxylation by CYP27A1.
Q40481988Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.
Q40161538Oxysterols are substrates for cholesterol sulfotransferase
Q36754829Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1
Q45091543Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis: increased levels in patients with pulmonary alveolar proteinosis
Q42414140Steroid hydroxylation by basidiomycete peroxygenases: a combined experimental and computational study
Q49167915Sterol 27-hydroxylase gene dosage and the antiatherosclerotic effect of Rifampicin in mice.
Q30392836Structural control of cytochrome P450-catalyzed ω-hydroxylation
Q34546874Structural motif-based homology modeling of CYP27A1 and site-directed mutational analyses affecting vitamin D hydroxylation
Q36227441The Essential Role of Cholesterol Metabolism in the Intracellular Survival of Mycobacterium leprae Is Not Coupled to Central Carbon Metabolism and Energy Production
Q55617722miR-204 functions as a tumor suppressor gene, at least partly by suppressing CYP27A1 in glioblastoma.

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