Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats

scientific article

Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1365-2567.2003.01672.X
P932PMC publication ID1782985
P698PubMed publication ID12807493
P5875ResearchGate publication ID10706703

P50authorKian Fan ChungQ43222898
P2093author name stringTimothy Oates
Paul R Eynott
Michael Salmon
Tung-Jung Huang
Paul L Nicklin
P2860cites workInterleukin-13: central mediator of allergic asthmaQ28291712
Rapamycin (sirolimus) inhibits proliferating cell nuclear antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cellsQ28378927
Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthmaQ34187085
Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway ratsQ35029119
Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transductionQ35319681
Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferationQ35819304
T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesisQ36363699
Effect of cyclosporine, mycophenolic acid, and rapamycin on the proliferation of rat aortic vascular smooth muscle cells: in vitro studyQ38525562
In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodelingQ40693637
Differential inhibition of cutaneous T-cell-mediated reactions and epidermal cell proliferation by cyclosporin A, FK-506, and rapamycinQ41056914
Interleukin-4 has basophilic and eosinophilic cell growth-promoting activity on cord blood cellsQ41757469
Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsiveness and inflammatory cell responses in sensitized Brown-Norway ratsQ41994020
Chemical modification of rapamycin: the discovery of SDZ RAD.Q42540012
Cyclosporine A reduces T lymphocyte activity and improves airway hyperresponsiveness in corticosteroid-dependent chronic severe asthma.Q42679645
Effect of rapamycin and FK506 on mesangial cell proliferationQ43552846
Guidelines for doctors in North AmericaQ43812823
Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice.Q43816385
Effect of topical immunomodulators on acute allergic inflammation and bronchial hyperresponsiveness in sensitised ratsQ43915760
Effects of rapamycin on growth factor-stimulated vascular smooth muscle cell DNA synthesis. Inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of rapamycin by FK506.Q46384707
IL-4 directs the development of Th2-like helper effectorsQ46390956
The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous systemQ48110278
Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycinQ54338613
Differential regulation of cytokine expression after allergen exposure of sensitized rats by cyclosporin A and corticosteroids: Relationship to bronchial hyperresponsivenessQ58450599
Rapamycin for immunosuppression in organ allografting.Q64891783
Trial of cyclosporin in corticosteroid-dependent chronic severe asthmaQ67513391
The immunosuppressive effect of rapamycin on pancreaticoduodenal transplants in the ratQ67697464
The influence of cyclosporin A on alloantibody responses in inbred rats: provisional evidence for a serum factor with antiidiotypic activityQ68095854
Cyclosporine therapy for severe atopic dermatitisQ69724076
The mechanics of airway narrowing in asthmaQ69938618
Differential effect of cyclosporin A (CyA) on IgE response: role of CyA-induced suppressor cellsQ70045068
Cyclosporine A inhibits airway reactivity and remodeling after chronic antigen challenge in catsQ71907037
Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophiliaQ71994193
Immunosuppressive effect of cyclosporin A in two lymphocyte transfer models in rats: comparison of in vivo and in vitro treatmentQ72121221
Inhibition of the accumulation, in rat kidney allografts, of specific--but not nonspecific--cytotoxic cells by cyclosporineQ72723896
Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthmaQ72876327
Attenuation of the allergen-induced late asthmatic reaction by cyclosporin A is associated with inhibition of bronchial eosinophils, interleukin-5, granulocyte macrophage colony-stimulating factor, and eotaxinQ73071747
Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodellingQ73136768
Contribution of upregulated airway endothelin-1 expression to airway smooth muscle and epithelial cell DNA synthesis after repeated allergen exposure of sensitized Brown-Norway ratsQ73149691
P433issue3
P921main subjectsirolimusQ32089
inflammationQ101991
cyclosporineQ367700
P304page(s)461-467
P577publication date2003-07-01
P1433published inImmunologyQ15754984
P1476titleEffects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats
P478volume109

Reverse relations

cites work (P2860)
Q36512788Effects of radix adenophorae and cyclosporine A on an OVA-induced murine model of asthma by suppressing to T cells activity, eosinophilia, and bronchial hyperresponsiveness
Q34915708Identification of two novel inhibitors of mTOR signaling pathway based on high content screening
Q37028215Immunosuppression and tumor development in organ transplant recipients: the emerging dualistic role of rapamycin
Q35060705Inhibition of protein kinase C delta attenuates allergic airway inflammation through suppression of PI3K/Akt/mTOR/HIF-1 alpha/VEGF pathway
Q48128838Metabolic Plasticity in Dendritic Cell Responses: Implications in Allergic Asthma.
Q28728802Paradoxical effects of rapamycin on experimental house dust mite-induced asthma
Q35566801Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma.
Q35789958Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung disease.
Q51624200Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice.
Q34574231Regulatory T cells in many flavors control asthma
Q39172901Targeting of protein translation as a new treatment paradigm for prostate cancer
Q38699320Targeting translation: eIF4E as an emerging anticancer drug target
Q33904734The Efficacy and Safety of Long-term Oral Cyclosporine Treatment for Patients with Atopic Dermatitis
Q64090619The Ethanol Extract of Larvae, Containing Fatty acids and Amino acids, Exerts Anti-Asthmatic Effects through Inhibition of the GATA-3/Th2 Signaling Pathway in Asthmatic Mice
Q24607170Updates of mTOR inhibitors
Q52801287[Expression and significance of mTOR/4EBP1/HIF-1α/VEGF signaling pathway in lung tissues of asthmatic mice].
Q37763231mTOR signaling in cancer cell motility and tumor metastasis

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