Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells

scientific article

Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M302559200
P698PubMed publication ID12821677

P2093author name stringLeonard Liebes
Roman Perez-Soler
Yiyu Zou
Yi-He Ling
P2860cites workCytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
A model for p53-induced apoptosisQ24313374
Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341Q27936558
Proliferation, cell cycle and apoptosis in cancerQ28189476
Death receptors: signaling and modulationQ28280897
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinaseQ28366319
The biochemistry of apoptosisQ29547741
Mitochondria and apoptosisQ29547905
The proteasome: paradigm of a self-compartmentalizing proteaseQ29615187
Mitochondrial control of cell deathQ29617739
Bcl-2 functions in an antioxidant pathway to prevent apoptosisQ29620401
p53 and apoptosisQ33547818
The role of the ubiquitin-proteasome pathway in apoptosisQ33669467
Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocatorQ33933168
Mitochondria as the central control point of apoptosisQ33994978
New agents in cancer clinical trialsQ34293629
Ceramide in apoptosis signaling: relationship with oxidative stressQ34369834
Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosisQ34441395
Outer mitochondrial membrane permeability can regulate coupled respiration and cell survivalQ35690379
Protein kinase C-alpha and ERK1/2 mediate mitochondrial dysfunction, decreases in active Na+ transport, and cisplatin-induced apoptosis in renal cellsQ35940937
The regulation of reactive oxygen species production during programmed cell deathQ36255441
Cyclosporin A inhibits caspase-independent death of NGF-deprived sympathetic neurons: a potential role for mitochondrial permeability transitionQ36324351
Mitochondrial permeability transition is a central coordinating event of apoptosisQ36367290
Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cellsQ40719792
Bcl-2 prevents Bax oligomerization in the mitochondrial outer membraneQ40816351
Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.Q40902473
Roles of ubiquitin-mediated proteolysis in cell cycle controlQ41678499
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.Q41972615
p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.Q42125448
Rate-limiting step preceding cytochrome c release in cells primed for Fas-mediated apoptosis revealed by analysis of cellular mosaicism of respiratory changesQ43508166
Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cellsQ43723445
Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cellsQ44024909
Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation.Q44215029
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis.Q44224227
Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenationQ44266729
Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL.Q44952270
Effective treatment of early endobronchial cancer with regional administration of liposome-p53 complexesQ45888786
Mitochondria as regulators of apoptosis: doubt no more.Q52531604
Cell Death in DevelopmentQ67531415
P433issue36
P407language of work or nameEnglishQ1860
P921main subjectreactive oxygen speciesQ424361
non-small-cell lung carcinomaQ3658562
apoptotic processQ14599311
P1104number of pages10
P304page(s)33714-33723
P577publication date2003-06-23
P1433published inJournal of Biological ChemistryQ867727
P1476titleReactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells
P478volume278