ACTH protects mature oligodendroglia from excitotoxic and inflammation-related damage in vitro

scientific article

ACTH protects mature oligodendroglia from excitotoxic and inflammation-related damage in vitro is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/GLIA.22504
P698PubMed publication ID23832579

P2093author name stringBeverly Bealmear
Joyce A Benjamins
Robert P Lisak
Liljana Nedelkoska
P2860cites workGlutamate uptake by oligodendrocytes: Implications for excitotoxicity in multiple sclerosisQ28212804
Glutamate and multiple sclerosisQ28258908
Induction of a Common Pathway of Apoptosis by StaurosporineQ29042381
Multiple sclerosisQ29616022
Stress and the brain: from adaptation to diseaseQ29619381
Brain corticosteroid receptor balance in health and diseaseQ29620564
The current evaluation and treatment of infantile spasms among members of the Child Neurology SocietyQ30455995
Binding of cholera toxin B subunit: a surface marker for murine microglia but not oligodendrocytes or astrocytesQ32027913
Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitisQ32065766
Non-N-methyl-D-aspartate glutamate receptors mediate oxygen--glucose deprivation-induced oligodendroglial injuryQ33180241
Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotypeQ33532294
NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalaciaQ33565598
Intravenous methylprednisolone for multiple sclerosis in relapseQ33620748
Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signalingQ33792422
Melanocortins and the treatment of nervous system disease. Potential relevance to the skin?Q33921707
Glycolipids and transmembrane signaling: antibodies to galactocerebroside cause an influx of calcium in oligodendrocytesQ33928786
Glucocorticoid protection of oligodendrocytes against excitotoxin involving hypoxia-inducible factor-1alpha in a cell-type-specific manner.Q34125992
Kynurenine pathway inhibition as a therapeutic strategy for neuroprotectionQ34247391
Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stressQ34337582
Brain effects of melanocortins.Q34599982
Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disordersQ34653971
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinasesQ34675057
The developing oligodendrocyte: key cellular target in brain injury in the premature infantQ34995998
Validation of the rat model of cryptogenic infantile spasms.Q35204574
Growth requirements in vitro of oligodendrocyte cell lines and neonatal rat brain oligodendrocytesQ35596332
Targeting melanocortin receptors as a novel strategy to control inflammation.Q35682900
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures.Q51586474
Postnatal expression of melanocortin-3 receptor in rat diencephalon and mesencephalon.Q52196350
Corticosteroids impair remyelination in the corpus callosum of cuprizone-treated mice.Q54363020
The melanocortin system in control of inflammation.Q55426694
Contrasting potential of nitric oxide and peroxynitrite to mediate oligodendrocyte injury in multiple sclerosisQ57041843
Randomised trial of oral and intravenous methylprednisolone in acute relapses of multiple sclerosisQ57416513
Glutamate excitotoxicity in a model of multiple sclerosisQ60450917
Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MSQ69351477
Expression of melanocortin 1 receptor in periaqueductal gray matterQ70986697
Solubilisation partial characterisation of the alpha-MSH receptor on primary rat Schwann cellsQ72659471
Comparison of the effects of oral versus intravenous methylprednisolone regimens on peripheral blood T lymphocyte adhesion molecule expression, T cell subsets distribution and TNF alpha concentrations in multiple sclerosisQ73270591
Cyclic GMP-dependent pathways protect differentiated oligodendrocytes from multiple types of injuryQ79453321
Ingested (oral) alpha-MSH inhibits acute EAEQ79968706
Same players, different game: AMPA receptor regulation in oligodendrocyte progenitorsQ82221469
Ingested (oral) ACTH inhibits EAEQ82472688
Oral ACTH (H.P. Acthar(®)Gel) inhibits IL-1 and IL-17 secretion in humansQ83242173
Cytokines reduce toxic effects of ethanol on oligodendrogliaQ83327219
Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal developmentQ36112101
Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebrosideQ36292898
Nitric oxide synthase expression and nitric oxide toxicity in oligodendrocytesQ36505638
Neurotransmitter-mediated calcium signalling in oligodendrocyte physiology and pathologyQ36606100
Excitotoxic damage to white matter.Q36822954
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell culturesQ37091141
Glutamatergic signaling in the brain's white matter.Q37100000
The role of kynurenines in disorders of the central nervous system: possibilities for neuroprotectionQ37408458
Distribution and function of melanocortin receptors within the brainQ37827455
Glutamate and ATP signalling in white matter pathologyQ37830727
Treatment of infantile spasms: emerging insights from clinical and basic science perspectivesQ37896402
Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and peripheryQ37972998
Corticosteroids for the treatment of infantile spasms: a systematic reviewQ38031818
Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.Q39476761
Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matterQ40315187
Signaling mechanisms controlled by melanocortins in melanoma, lacrimal, and brain astroglial cellsQ40855157
Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in cultureQ40925821
Alpha-MSH peptides inhibit production of nitric oxide and tumor necrosis factor-alpha by microglial cells activated with beta-amyloid and interferon gammaQ40929097
Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia.Q41035747
Cyclic AMP-elevating agents prevent oligodendroglial excitotoxicity.Q41039902
Melanocortin analogue Org2766 binds to rat Schwann cells, upregulates NGF low-affinity receptor p75, and releases neurotrophic activityQ41398478
Cerebral white matter contains PDGF-responsive precursors to O2A cellsQ41731670
Characterization of specific binding sites for [3H]-staurosporine on various protein kinasesQ41785129
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for glial and neural-related molecules in central nervous system mixed glial cell cultures: neurotrophins, growth factors and structural proteinsQ41825402
The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) therapyQ41975249
Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinaseQ42216028
Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP-protein kinase A pathwayQ42492353
The receptor subunits generating NMDA receptor mediated currents in oligodendrocytesQ42957371
A short-term randomized MRI study of high-dose oral vs intravenous methylprednisolone in MS.Q43233446
Oligodendrocyte killing by quinolinic acid in vitroQ43558984
Multiple sclerosis: altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damageQ43708042
Proligodendroblast antigen (POA), a developmental antigen expressed by A007/O4-positive oligodendrocyte progenitors prior to the appearance of sulfatide and galactocerebrosideQ43899714
Mature myelin basic protein-expressing oligodendrocytes are insensitive to kainate toxicityQ44263018
Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosisQ44477073
Treatment of cerebral ischemia with melanocortins acting at MC4 receptors induces marked neurogenesis and long-lasting functional recoveryQ44880939
Excitatory amino acid induced oligodendrocyte cell death in vitro: receptor-dependent and -independent mechanismsQ45018878
The bioavailability of IV methylprednisolone and oral prednisone in multiple sclerosisQ45081500
Functional glutamate transport in rodent optic nerve axons and glia.Q45904559
Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.Q46083107
Oral prednisone taper following intravenous steroids fails to improve disability or recovery from relapses in multiple sclerosisQ46609780
Action of adrenocorticotropic hormone (ACTH) in experimental allergic encephalomyelitis of the guinea pig.Q46889143
Alpha-MSH rescues neurons from excitotoxic cell deathQ46938298
Glutamate receptor expression in multiple sclerosis lesionsQ46959335
Alpha-MSH inhibits inflammatory signalling in Schwann cells.Q47740805
Redistribution and internalization of antibodies to galactocerebroside by oligodendrogliaQ48104091
Activation of melanocortin 4 receptors reduces the inflammatory response and prevents apoptosis induced by lipopolysaccharide and interferon-gamma in astrocytesQ48124765
Effective use of a neurotrophic ACTH4-9 analogue in the treatment of a peripheral demyelinating syndrome (experimental allergic neuritis). An intervention studyQ48142711
Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and preventionQ48316824
Identification of differential melanocortin 4 receptor agonist profiles at natively expressed receptors in rat cortical astrocytes and recombinantly expressed receptors in human embryonic kidney cells.Q48374865
Melanocortins stimulate proliferation and induce morphological changes in cultured rat astrocytes by distinct transducing mechanismsQ48506174
Secretory products of central nervous system glial cells induce Schwann cell proliferation and protect from cytokine-mediated death.Q50480296
P433issue8
P921main subjectinflammationQ101991
neurogliaQ177105
excitotoxicityQ901117
oligodendrocyteQ916698
P304page(s)1206-1217
P577publication date2013-07-05
P1433published inGliaQ15716658
P1476titleACTH protects mature oligodendroglia from excitotoxic and inflammation-related damage in vitro
P478volume61

Reverse relations

cites work (P2860)
Q89736123Activation of Melanocortin-4 Receptor Inhibits Both Neuroinflammation Induced by Early Exposure to Ethanol and Subsequent Voluntary Alcohol Intake in Adulthood in Animal Models: Is BDNF the Key Mediator?
Q54116484Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice.
Q27319946Attention deficit associated with early life interictal spikes in a rat model is improved with ACTH
Q47175603Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase
Q41995287Dock3 protects myelin in the cuprizone model for demyelination
Q46932015Effects of dextromethorphan on glial cell function: proliferation, maturation, and protection from cytotoxic molecules
Q34381234Excitotoxic brain injury in adult zebrafish stimulates neurogenesis and long-distance neuronal integration
Q38756563Kynurenic Acid Induces Impairment of Oligodendrocyte Viability: On the Role of Glutamatergic Mechanisms
Q26865343Melanocortin peptides: potential targets in systemic lupus erythematosus
Q46311295Melanocortin receptor subtypes are expressed on cells in the oligodendroglial lineage and signal ACTH protection.
Q41552761Melanocortins, Melanocortin Receptors and Multiple Sclerosis
Q37737604New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis.

Search more.