The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression

scientific article published in November 2003

The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1046402466
P356DOI10.1038/SJ.LEU.2403111
P698PubMed publication ID12931221
P5875ResearchGate publication ID10603738

P2093author name stringBortul R
Martelli AM
Zweyer M
Tabellini G
Tazzari PL
Cocco L
Billi AM
Cappellini A
Falà F
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Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cellsQ44133598
Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemiaQ44279382
Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulationQ44319730
Retinoblastoma protein-overexpressing HL60 cells resistant to 1,25-dihydroxyvitamin D3 display increased CDK2 and CDK6 activity and shortened G1 phaseQ47886741
PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignanciesQ57591287
Breast cancer banishes p27 from nucleusQ78306567
Direct control of the Forkhead transcription factor AFX by protein kinase BQ22009452
Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.Q24514761
CDK inhibitors: positive and negative regulators of G1-phase progressionQ27860983
DNA replication in eukaryotic cellsQ28131747
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancerQ28203143
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2Q28216784
CREB is a regulatory target for the protein kinase Akt/PKBQ28289946
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21Q28505037
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase BQ28638147
The protein kinase B/Akt signalling pathway in human malignancyQ28645742
Cell cycle and death control: long live ForkheadsQ28646130
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1Q29617416
SHIPs ahoyQ33785109
Safety and antitumor activity of recombinant soluble Apo2 ligandQ33855449
AKT plays a central role in tumorigenesisQ33944165
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.Q34099883
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localizationQ34150579
Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT).Q34150787
Checking out the G(2)/M transition.Q34282259
Ten years of protein kinase B signalling: a hard Akt to followQ34432885
Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genesQ34493133
Regulation of cyclin-Cdk activity in mammalian cellsQ34531931
The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system.Q34973870
New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?Q35057304
Flow cytometric detection of total and serine 473 phosphorylated Akt.Q40636307
Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligandQ40656051
A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cellsQ40686902
Regulation of myeloma cell growth through Akt/Gsk3/forkhead signaling pathwayQ40700367
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrestQ40702262
Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.Q40831748
Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disordersQ40857867
Mutation analysis of PTEN/MMAC1 in acute myeloid leukemiaQ40895282
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.Q40975748
P433issue11
P304page(s)2157-2167
P577publication date2003-11-01
P1433published inLeukemiaQ6534498
P1476titleThe phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression
P478volume17

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cites work (P2860)
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