Effects of neurosteroids on epileptiform activity induced by picrotoxin and 4-aminopyridine in the rat hippocampal slice

scientific article published in June 2003

Effects of neurosteroids on epileptiform activity induced by picrotoxin and 4-aminopyridine in the rat hippocampal slice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0920-1211(03)00112-8
P8608Fatcat IDrelease_mywgdo3tzrcc5jzj62ph3tkwey
P698PubMed publication ID12948618

P50authorMichael A RogawskiQ42775980
P2093author name stringRicardo Tapia
Patricia Salazar
P2860cites workDirect activation of GABAA receptors by barbiturates in cultured rat hippocampal neuronsQ24530665
Neurosteroids: biochemistry and clinical significanceQ28212390
Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in miceQ28319491
Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunitQ28363363
Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sitesQ33863668
Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility.Q34125750
Neurosteroids act on recombinant human GABAA receptorsQ34187011
Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in cultured rat hippocampal neurons.Q34251622
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptorQ34384840
Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro.Q35008651
The contrasting effects of dendrotoxins and other potassium channel blockers in the CA1 and dentate gyrus regions of rat hippocampal slicesQ35026688
Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significanceQ35254149
Poisoning with 4-Aminopyridine: Report of Three CasesQ40121644
Neurosteroids and GABAA receptor function.Q40372468
Pregneolone--from Selye to Alzheimer and a model of the pregnenolone sulfate binding site on the GABAA receptorQ40582099
Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture.Q40717579
Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-oneQ41327094
Protective effects of neurosteroids against NMDA-induced seizures and lethality in mice.Q42450331
Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in miceQ42549975
Modulation of the GABAA receptor complex by steroids in slices of rat cuneate nucleusQ42848202
Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroidQ43639812
Effects of antiepileptic drugs on 4-aminopyridine-induced epileptiform activity in young and adult rat hippocampusQ43842450
Paired pulse facilitation is turned into paired pulse depression in hippocampal slices after epilepsy induced by 4-aminopyridine in vivoQ43996581
Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors.Q44013200
Neurosteroids enhance bandpass filter characteristics of the rat Schaffer collateral-to-CA1 synapseQ44019662
Physiology and pharmacology of epileptiform activity induced by 4-aminopyridine in rat hippocampal slicesQ44267443
4-Aminopyridine produces epileptiform activity in hippocampus and enhances synaptic excitation and inhibitionQ44430969
Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomesQ44467995
Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequencyQ44984744
Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in miceQ45209725
Suppression of 4-aminopyridine-induced epileptogenesis by the GABAA agonist muscimolQ46159097
Calcium current block by (-)-pentobarbital, phenobarbital, and CHEB but not (+)-pentobarbital in acutely isolated hippocampal CA1 neurons: comparison with effects on GABA-activated Cl- currentQ46346412
Convulsant actions of the neurosteroid pregnenolone sulfate in miceQ48159399
Neurosteroid modulation of synaptic and GABA-evoked currents in neurons from the rat medial preoptic nucleusQ48167013
Relationships among seizures, extracellular amino acid changes, and neurodegeneration induced by 4-aminopyridine in rat hippocampus: a microdialysis and electroencephalographic studyQ48227493
Mechanism of the calcium-dependent stimulation of transmitter release by 4-aminopyridine in synaptosomesQ48425685
Spontaneous epileptiform discharges in hippocampal slices induced by 4-aminopyridineQ48454053
Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroidsQ48587221
Plasticity in fast synaptic inhibition of adult oxytocin neurons caused by switch in GABA(A) receptor subunit expressionQ48589858
4-aminopyridine-induced epileptiform activity and a GABA-mediated long- lasting depolarization in the rat hippocampusQ48602703
Recruitment of GABAergic Inhibition and Synchronization of Inhibitory Interneurons in Rat NeocortexQ48692989
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.Q48707854
Synchronized GABAergic IPSPs recorded in the neocortex after blockade of synaptic transmission mediated by excitatory amino acidsQ48736161
Effect of 4-aminopyridine on transmitter release in synaptosomesQ48874217
Binding of pregnenolone sulfate to rat brain membranes suggests multiple sites of steroid action at the GABAA receptorQ48875763
Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptorsQ48920022
Neuroprotective effects of allopregnenolone on hippocampal irreversible neurotoxicity in vitroQ49131090
Action of 4-aminopyridine on extracellular amino acids in hippocampus and entorhinal cortex: a dual microdialysis and electroencehalographic study in awake ratsQ49159401
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channelsQ49160604
Pregnanolone: a highly potent, naturally occurring hypnotic-anesthetic agent.Q51210144
Some effects of progesterone and related steroids on the central nervous system.Q51214328
Infusion of 3alpha,5alpha-THP to the pontine reticular formation attenuates PTZ-induced seizures.Q51375192
Anaesthetic effects of pregnanolone in combination with allopregnanolone, thiopental, hexobarbital and flurazepam: an EEG study in the rat.Q51435486
Preferential stimulation of glutamate release by 4-aminopyridine in rat striatum in vivo.Q51582842
Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5β-pregnan-20-one in rodentsQ51610510
Modulation of the GABAA receptor by progesterone metabolites.Q51786634
The anaesthetic potency of 3 alpha-hydroxy-5 alpha-pregnan-20-one and 3 alpha-hydroxy-5 beta-pregnan-20-one determined with an intravenous EEG-threshold method in male rats.Q51788949
Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitroQ57043017
Recent developments in structure–activity relationships for steroid modulators of GABAA receptorsQ57987519
NMDA receptor antagonists protect against seizures and wet-dog shakes induced by 4-aminopyridineQ67575799
Steroid hormone effects on picrotoxin-induced seizures in female and male ratsQ69579349
Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain?Q70173942
Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridineQ71546515
Pregnenolone sulfate potentiation of NMDA-mediated increases in intracellular calcium in cultured chick cortical neuronsQ72145571
Action of Some Steroids on the Central Nervous System of the Mouse. II. PharmacologyQ72705606
Aminopyridines and synaptic transmissionQ72860070
Different effects of GABAergic anticonvulsants on 4-aminopyridine-induced spontaneous GABAergic hyperpolarizations of hippocampal pyramidal cells--implication for their potency in migraine therapyQ73183437
Effects of neurosteroids on Ca(2+) signaling mediated by recombinant N-methyl-D-aspartate receptor expressed in Chinese hamster ovary cellsQ73539475
Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slicesQ73556812
Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitizationQ73770774
Proconvulsant effects of neurosteroids pregnenolone sulfate and dehydroepiandrosterone sulfate in miceQ74567145
P433issue1-2
P304page(s)71-82
P577publication date2003-06-01
P1433published inEpilepsy ResearchQ15746405
P1476titleEffects of neurosteroids on epileptiform activity induced by picrotoxin and 4-aminopyridine in the rat hippocampal slice
P478volume55

Reverse relations

cites work (P2860)
Q48214543Allopregnanolone potentiates the glutamate-mediated seizures induced by 4-aminopyridine in rat hippocampus in vivo
Q24532929Anticonvulsant activity of androsterone and etiocholanolone.
Q30438059Critical roles for fast synaptic transmission in mediating estradiol negative and positive feedback in the neural control of ovulation
Q36456365Depolarising and hyperpolarising actions of GABA(A) receptor activation on gonadotrophin-releasing hormone neurones: towards an emerging consensus.
Q46857416Effects of retigabine on the neurodegeneration and extracellular glutamate changes induced by 4-aminopyridine in rat hippocampus in vivo
Q37225136Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions
Q37115526GABA effects during neuronal differentiation of stem cells.
Q30434370GABAergic integration of progesterone and androgen feedback to gonadotropin-releasing hormone neurons
Q30439925Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol
Q36932154Limbic networks and epileptiform synchronization: the view from the experimental side.
Q33667168Mechanism of Potentiation of a Dysfunctional Epilepsy-Linked Mutated GABAA Receptor by a Neurosteroid (3α, 21-Dihydroxy-5α-pregnan-20-one): Transient Kinetic Investigations
Q34545011Method to reconstruct neuronal action potential train from two-photon calcium imaging
Q42761640Neurosteroidal modulation of in vitro epileptiform activity is enhanced in pilocarpine-treated epileptic rats.
Q41946293Neurosteroids differentially modulate fast and slow interictal discharges in the hippocampal CA3 area
Q42754615Neurosteroids modulate epileptiform activity and associated high-frequency oscillations in the piriform cortex
Q36542199Postnatal inflammation increases seizure susceptibility in adult rats.
Q46685364Sex steroids effects on the content of GAD, TH, GABA(A), and glutamate receptors in the olfactory bulb of the male rat.
Q37686594Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy.
Q44987792Transient plasticity of hippocampal CA1 neuron glutamate receptors contributes to benzodiazepine withdrawal-anxiety

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