Intersubunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity

scientific article published in August 2008

Intersubunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1036103127
P356DOI10.1038/CDD.2008.114
P698PubMed publication ID18670436
P5875ResearchGate publication ID23140772

P2093author name stringY Wang
W Zhang
S Israel
L Bianchi
W-H Lee
M Driscoll
P2860cites workTemperature-sensitive mutant of the Caenorhabditis elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface maintenanceQ50656321
Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domainQ71938494
Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neuronsQ81078484
Interaction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependentQ24684643
Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pHQ27648371
Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell deathQ28217736
Selective regulation of acid-sensing ion channel 1 by serine proteasesQ28271387
DNA transformationQ29616766
Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism mapQ29618616
Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1aQ33697259
A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegansQ33930492
Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulumQ34093243
Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.Q34348555
Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.Q34711250
A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3.Q36295995
Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockadeQ36299668
A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegansQ38311352
Chapter 14 Methods for the Study of Cell Death in the Nematode Caenorhabditis elegansQ40443426
MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensationQ43903505
The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signalsQ45174134
In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensationQ46089826
The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiationQ46229892
Trypsin cleaves acid-sensing ion channel 1a in a domain that is critical for channel gatingQ46799721
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channelQ47069206
Developmental genetics of the mechanosensory neurons of Caenorhabditis elegansQ47069518
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegansQ48085066
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degenerationQ48235681
In vivo structure-function analyses of Caenorhabditis elegans MEC-4, a candidate mechanosensory ion channel subunit.Q50497285
P433issue11
P921main subjectneurotoxicityQ3338704
Degenerin mec-4 CELE_T01C8.7Q29793134
Degenerin mec-10 CELE_F16F9.5Q29803542
P304page(s)1794-1803
P577publication date2008-08-01
P1433published inCell Death & DifferentiationQ2943974
P1476titleIntersubunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity
P478volume15

Reverse relations

cites work (P2860)
Q37041556CLHM-1 is a functionally conserved and conditionally toxic Ca2+-permeable ion channel in Caenorhabditis elegans
Q39269905Ca2+ permeability and Na+ conductance in cellular toxicity caused by hyperactive DEG/ENaC channels
Q38048561Insight into DEG/ENaC channel gating from genetics and structure
Q37394153Insights into the molecular determinants of proton inhibition in an acid-inactivated degenerins and mammalian epithelial Na(+) channel
Q38618355Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans.
Q30416737Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans
Q37727615NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels
Q37055480Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations
Q30431363SRGP-1 regulation, targets, and contribution to cell killing in C. elegans
Q35819038Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC).
Q34430460Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.
Q35923582The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons
Q36642232The genetic architecture of degenerin/epithelial sodium channels in Drosophila

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