Therapeutic significance of Y-27632, a Rho-kinase inhibitor, on the established liver fibrosis

scientific article published in September 2003

Therapeutic significance of Y-27632, a Rho-kinase inhibitor, on the established liver fibrosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0022-4804(03)00202-6
P698PubMed publication ID13678700

P2093author name stringShigeki Arii
Masayuki Imamura
Akira Mori
Toru Murata
P2860cites workThe activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formationQ28207920
Transforming growth factor beta in tissue fibrosisQ28239292
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionQ29614247
Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.Q33632161
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injuryQ33822590
The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin, and nitric oxideQ34063927
Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptorsQ34580643
Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesisQ35595788
Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferationQ35750826
Expression of the Na+/Ca2+ exchanger emerges in hepatic stellate cells after activation in association with liver fibrosisQ36070728
Cloning of the rat heart Na(+)-Ca2+ exchanger and its functional expression in HeLa cellsQ36775195
Cloning of two isoforms of the rat brain Na(+)-Ca2+ exchanger gene and their functional expression in HeLa cellsQ36778221
Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cellsQ39418552
Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchangerQ39751987
Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic beta-cellsQ40140809
Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategiesQ40911465
Role of Rho small GTP binding protein in the regulation of actin cytoskeleton in hepatic stellate cellsQ40939225
The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonusQ42483083
A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in ratsQ43631422
Rho directs activation-associated changes in rat hepatic stellate cell morphology via regulation of the actin cytoskeletonQ43651093
Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cellsQ43780882
Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchangerQ48144861
Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway.Q52537460
Apoptosis Induced by Transforming Growth Factor- in Fetal Hepatocyte Primary CulturesQ59650992
Angiotensin II induces contraction and proliferation of human hepatic stellate cellsQ61576239
Expression of the gene of the alpha-smooth muscle-actin isoform in rat liver and in rat fat-storing (ITO) cellsQ67683697
Lysophosphatidic acid enhances collagen gel contraction by hepatic stellate cells: association with rho-kinaseQ73067387
ROCK inhibitor Y-27632 attenuates stellate cell contraction and portal pressure increase induced by endothelin-1Q73278140
Wound-induced migration of rat hepatic stellate cells is modulated by endothelin-1 through rho-kinase-mediated alterations in the acto-myosin cytoskeletonQ73315471
A p160ROCK-specific inhibitor, Y-27632, attenuates rat hepatic stellate cell growthQ73876502
Portal branch ligation with a continuous hepatocyte growth factor supply makes extensive hepatectomy possible in cirrhotic ratsQ77220675
Fibrosis accelerates the development of enzyme-altered lesions in the rat liverQ77485734
P433issue1
P304page(s)64-71
P577publication date2003-09-01
P1433published inJournal of Surgical ResearchQ15763329
P1476titleTherapeutic significance of Y-27632, a Rho-kinase inhibitor, on the established liver fibrosis
P478volume114

Reverse relations

cites work (P2860)
Q37204720Effects of phased joint intervention on Rho/ROCK expression levels in patients with portal hypertension
Q53287289Epithelial–mesenchymal transition of rat peritoneal mesothelial cells via Rhoa/Rock pathway
Q34911441Heat shock proteins modulate keloid formation
Q90648282Hepatic microcirculation and mechanisms of portal hypertension
Q42789129Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the Rho-kinase inhibitor Y27632.
Q42667685Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis
Q92658202Pharmacological inhibition of LIM kinase pathway impairs platelets functionality and facilitates thrombolysis
Q37578037Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha
Q84563833Plasma membrane calcium ATPase isoform 3 expression in single cells isolated from rat liver
Q34265555Rho/Rock cross-talks with transforming growth factor-β/Smad pathway participates in lung fibroblast-myofibroblast differentiation
Q37960141Specific delivery of kinase inhibitors in nonmalignant and malignant diseases.
Q37317622Stellate cell contraction: role, regulation, and potential therapeutic target
Q37150782Suppressive effect of orthovanadate on hepatic stellate cell activation and liver fibrosis in rats
Q28293417The CD47-binding peptide of thrombospondin-1 induces defenestration of liver sinusoidal endothelial cells
Q97075318Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications
Q36973742Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells

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