The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax.

scientific article published on 15 June 2017

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3324/HAEMATOL.2016.162958
P932PMC publication ID5685241
P698PubMed publication ID28619845

P50authorJosé Saura-EstellerQ64001843
Daniel Iglesias-SerretQ39031912
P2093author name stringAna M Cosialls
Diana M González-Gironès
Gabriel Pons
Joan Gil
Fernando Albericio
Rodolfo Lavilla
Esmeralda de la Banda
Helena Pomares
Sara Preciado
Eva M González-Barca
Sonia Núñez-Vázquez
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A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulationQ28269042
The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2Q28275561
Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytesQ44274481
Analysis of apoptosis regulatory genes altered by histone deacetylase inhibitors in chronic lymphocytic leukemia cells.Q53218427
Prohibitin expression is increased in phorbol ester-treated chronic leukemic B-lymphocytesQ31853290
Acadesine for patients with relapsed/refractory chronic lymphocytic leukemia (CLL): a multicenter phase I/II studyQ33404763
Ibrutinib for relapsed/refractory chronic lymphocytic leukemia: a UK and Ireland analysis of outcomes in 315 patientsQ33821990
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trialQ34141305
Regulation of Syk by phosphorylation on serine in the linker insertQ34400900
Bendamustine is effective in p53-deficient B-cell neoplasms and requires oxidative stress and caspase-independent signalingQ34599670
Prohibitin and mitochondrial biologyQ35001369
Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-CellsQ35852684
Ibrutinib resistance in chronic lymphocytic leukemiaQ35881570
Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic LeukemiaQ35958056
The role and therapeutic potential of prohibitin in diseaseQ36018450
The BCL-2 protein family, BH3-mimetics and cancer therapyQ36067778
An interconnected hierarchical model of cell death regulation by the BCL-2 familyQ36109186
Initial treatment of CLL: integrating biology and functional statusQ36219647
Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes.Q36514204
Rapid induction of apoptosis in chronic lymphocytic leukemia cells by the microtubule disrupting agent BNC105.Q36844333
The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivoQ37187540
Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells.Q37470898
Prohibitins and the functional compartmentalization of mitochondrial membranes.Q37627477
The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related proteinQ37635432
From pathogenesis to treatment of chronic lymphocytic leukaemiaQ37643423
Targeting prohibitins induces apoptosis in acute myeloid leukemia cells.Q37662175
Prohibitin ligands in cell death and survival: mode of action and therapeutic potentialQ38092225
Chronic lymphocytic leukemia: 2013 update on diagnosis, risk stratification and treatmentQ38110472
The molecular pathogenesis of chronic lymphocytic leukaemiaQ38748645
BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199.Q38776895
Front-line treatment of CLL in the era of novel agentsQ39084142
Outcomes of CLL patients treated with sequential kinase inhibitor therapy: a real world experience.Q39416260
Fludarabine nucleoside modulates nuclear "survival and death" proteins in resistant chronic lymphocytic leukemia cellsQ39434653
AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.Q39674990
Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa.Q40127987
Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathwaysQ40315433
Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA.Q42384351
P433issue9
P921main subjectchronic lymphocytic leukemiaQ1088156
ibrutinibQ5984881
P304page(s)1587-1593
P577publication date2017-06-15
P1433published inHaematologicaQ5638209
P1476titleThe prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax
P478volume102

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cites work (P2860)
Q55253157Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment.
Q50158386The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model

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