| scholarly article | Q13442814 |
| P50 | author | James R Cypser | Q57321146 |
| Marc Tatar | Q61115357 | ||
| P2093 | author name string | Robert J Wessells | |
| Rolf Bodmer | |||
| Erin Fitzgerald | |||
| P2860 | cites work | The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling | Q24794823 |
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| atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain | Q47072663 | ||
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| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | 1275-1281 | |
| P577 | publication date | 2004-11-21 | |
| P1433 | published in | Nature Genetics | Q976454 |
| P1476 | title | Insulin regulation of heart function in aging fruit flies | |
| P478 | volume | 36 |
| Q36716324 | A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX |
| Q27325739 | A Drosophila model of high sugar diet-induced cardiomyopathy |
| Q33656535 | A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. |
| Q37292411 | A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment |
| Q35084589 | A method to measure myocardial calcium handling in adult Drosophila |
| Q30494115 | A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts |
| Q35123281 | ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections |
| Q37289065 | Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila |
| Q64248731 | Age-Dependent Changes in Transcription Factor FOXO Targeting in Female |
| Q36663066 | Age-related cardiac disease model of Drosophila |
| Q34024014 | Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network |
| Q89653834 | Associations among echocardiography, cardiac biomarkers, insulin metabolism, morphology, and inflammation in cats with asymptomatic hypertrophic cardiomyopathy |
| Q36835824 | Autophagy drives epidermal deterioration in a Drosophila model of tissue aging. |
| Q64107020 | Beetles as Model Organisms in Physiological, Biomedical and Environmental Studies - A Review |
| Q37126644 | Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models? |
| Q37442678 | Cardiac aging and insulin resistance: could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target? |
| Q33806910 | Cardiac aging in mice and humans: the role of mitochondrial oxidative stress |
| Q35898648 | Cardiac aging: from molecular mechanisms to significance in human health and disease |
| Q35542054 | Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster |
| Q36010896 | Comparative Analysis of Transcriptomes among Bombyx mori Strains and Sexes Reveals the Genes Regulating Melanic Morph and the Related Phenotypes |
| Q27015827 | Comparative approaches to the study of physiology: Drosophila as a physiological tool. |
| Q36431795 | Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice |
| Q36983890 | Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy |
| Q36608681 | Dietary composition regulates Drosophila mobility and cardiac physiology. |
| Q46857105 | Direct influence of serotonin on the larval heart of Drosophila melanogaster |
| Q35947444 | Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies. |
| Q54334575 | Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization. |
| Q34018870 | Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels |
| Q35757993 | Drosophila aging 2005/06 |
| Q36421000 | Drosophila aging 2006/2007 |
| Q33726975 | Drosophila as a Model for Diabetes and Diseases of Insulin Resistance |
| Q30476715 | Drosophila as a model for the identification of genes causing adult human heart disease |
| Q37942884 | Drosophila as a tool for personalized medicine: a primer |
| Q36609160 | Drosophila germ-line modulation of insulin signaling and lifespan |
| Q49415841 | Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly |
| Q36405771 | Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain |
| Q36588723 | Drosophila lifespan control by dietary restriction independent of insulin-like signaling |
| Q37607998 | Drosophila melanogaster as a model system for genetics of postnatal cardiac function |
| Q37850142 | Drosophila models of cardiac disease. |
| Q50188453 | Drosophila tafazzin mutants have impaired exercise capacity. |
| Q34216750 | Drosophila, genetic screens, and cardiac function |
| Q35998774 | Drosophila, the golden bug, emerges as a tool for human genetics |
| Q30493760 | Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype |
| Q36540431 | E2F function in muscle growth is necessary and sufficient for viability in Drosophila |
| Q52724287 | Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation. |
| Q37304972 | Embryonic even skipped-dependent muscle and heart cell fates are required for normal adult activity, heart function, and lifespan. |
| Q35671770 | Emerging models and paradigms for stem cell ageing |
| Q36100659 | Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms |
| Q51767065 | Endurance exercise prevents high-fat-diet induced heart and mobility premature aging and dsir2 expression decline in aging Drosophila. |
| Q27348552 | Exercise-training in young Drosophila melanogaster reduces age-related decline in mobility and cardiac performance |
| Q46406593 | Experimental Evolution and Heart Function in Drosophila. |
| Q37592027 | Expression patterns of cardiac aging in Drosophila |
| Q29620472 | FOXO transcription factors at the interface between longevity and tumor suppression |
| Q42705331 | FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging |
| Q43622039 | FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency |
| Q37129813 | Forkhead transcription factors and ageing |
| Q38611590 | Gaining Insights into Diabetic Cardiomyopathy from Drosophila |
| Q38036240 | Genes and networks regulating cardiac development and function in flies: genetic and functional genomic approaches |
| Q35945999 | Genetic control of heart function and aging in Drosophila |
| Q38523086 | Genetic manipulation of cardiac ageing |
| Q27302935 | Genetic variation for cardiac dysfunction in Drosophila |
| Q35176374 | Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling |
| Q34007830 | Genotype-by-diet interactions drive metabolic phenotype variation in Drosophila melanogaster. |
| Q96303481 | Glucocorticoid Signaling and the Aging Heart |
| Q26852243 | Growth factors, nutrient signaling, and cardiovascular aging |
| Q36145394 | Heart-specific Rpd3 downregulation enhances cardiac function and longevity |
| Q30497986 | High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila |
| Q35410739 | Increased Akt signaling in the mosquito fat body increases adult survivorship. |
| Q35582500 | Insulin and JNK: optimizing metabolic homeostasis and lifespan |
| Q46282880 | Insulin breaks hearts. |
| Q35103675 | Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan |
| Q90661468 | Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling |
| Q34735251 | Insulin/IGF-1 signaling, including class II/III PI3Ks, β-arrestin and SGK-1, is required in C. elegans to maintain pharyngeal muscle performance during starvation |
| Q53346541 | Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. |
| Q60909393 | Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila |
| Q34018412 | Intertissue control of the nucleolus via a myokine-dependent longevity pathway |
| Q37306689 | JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila |
| Q24681227 | KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging |
| Q27345444 | Lifespan extension by preserving proliferative homeostasis in Drosophila |
| Q36383185 | Metabolomic and Gene Expression Profiles Exhibit Modular Genetic and Dietary Structure Linking Metabolic Syndrome Phenotypes in Drosophila |
| Q26822579 | Methods to assess Drosophila heart development, function and aging |
| Q47072694 | Methylene blue rescues heart defects in a Drosophila model of Friedreich's ataxia. |
| Q35985017 | Misexpression screen delineates novel genes controlling Drosophila lifespan |
| Q58611338 | Mito-nuclear interactions modify Drosophila exercise performance |
| Q28389063 | Mitochondrial dysfunction in cardiac aging |
| Q37592017 | Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline |
| Q33535892 | Molecular evolution and functional characterization of Drosophila insulin-like peptides |
| Q37956231 | Molecular mechanisms for anti-aging by natural dietary compounds. |
| Q37575136 | Molecular mechanisms of heart failure: insights from Drosophila |
| Q28306903 | Multiple measures of functionality exhibit progressive decline in a parallel, stochastic fashion in Drosophila Sod2 null mutants |
| Q36817447 | Neuronal inputs and outputs of aging and longevity |
| Q36791476 | New model of health promotion and disease prevention for the 21st century |
| Q33693863 | Non-autonomous modulation of heart rhythm, contractility and morphology in adult fruit flies. |
| Q96815974 | Non-invasive red-light optogenetic control of Drosophila cardiac function |
| Q37826987 | Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms |
| Q52719820 | Observations of cardiac beating behaviors of wild-type and mutant Drosophilae with optical coherence tomography. |
| Q36400110 | Organ-specific mediation of lifespan extension: more than a gut feeling? |
| Q21563377 | Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects |
| Q35038201 | Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? |
| Q27321131 | PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase |
| Q37295044 | Partial loss of GATA factor Pannier impairs adult heart function in Drosophila |
| Q36506541 | Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction. |
| Q34497344 | Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila |
| Q36682368 | Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy |
| Q35135198 | Premature cardiac senescence in DahlS.Z-Lepr(fa)/Lepr(fa) rats as a new animal model of metabolic syndrome |
| Q35916542 | Probing the polygenic basis of cardiomyopathies in Drosophila |
| Q37402142 | Promoting longevity by maintaining metabolic and proliferative homeostasis |
| Q37411863 | Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling |
| Q58543677 | Quantifying Tissue-Specific Overexpression of FOXO in Drosophila via mRNA Fluorescence In Situ Hybridization Using Branched DNA Probe Technology |
| Q30586973 | ROS regulate cardiac function via a distinct paracrine mechanism. |
| Q37228766 | Rapamycin extends life- and health span because it slows aging |
| Q34966664 | RasGrf1 deficiency delays aging in mice. |
| Q33829934 | Regulation of Drosophila Lifespan by bellwether Promoter Alleles |
| Q37091119 | Role of insulin-like growth factor 1 and phosphoinositide 3-kinase in a setting of heart disease |
| Q33898278 | SH2B regulation of growth, metabolism, and longevity in both insects and mammals |
| Q27340405 | SPARC-Dependent Cardiomyopathy in Drosophila |
| Q28590387 | Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies |
| Q24633564 | Sestrins at the crossroad between stress and aging |
| Q45299763 | Sexual dimorphism in obesity-related genes in the epicardial fat during aging |
| Q37061424 | Sirt1 protects the heart from aging and stress. |
| Q37337943 | Sod2 knockdown in the musculature has whole-organism consequences in Drosophila. |
| Q92265740 | Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan |
| Q37794096 | Stressin' Sestrins take an aging fight |
| Q33791037 | Studying aging in Drosophila |
| Q35033150 | The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman |
| Q38578328 | The Aging Heart |
| Q34163670 | The Drosophila PGC-1α homolog spargel modulates the physiological effects of endurance exercise |
| Q52609164 | The Drosophila TGF-beta/Activin-like ligands Dawdle and Myoglianin appear to modulate adult lifespan through regulation of 26S proteasome function in adult muscle. |
| Q34013124 | The FoxO family in cardiac function and dysfunction |
| Q29617238 | The cell-non-autonomous nature of electron transport chain-mediated longevity |
| Q39271750 | The functional costs and benefits of dietary restriction in Drosophila. |
| Q47652116 | The impact of SPARC on age-related cardiac dysfunction and fibrosis in Drosophila |
| Q36006533 | The intersection between aging and cardiovascular disease |
| Q28083445 | The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster |
| Q30665184 | Time-restricted feeding attenuates age-related cardiac decline in Drosophila |
| Q28511985 | Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species |
| Q34901262 | Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease |
| Q58725539 | Unraveling the Molecular Mechanism of Immunosenescence in |
| Q49966367 | Using Drosophila to Understand Biochemical and Behavioral Responses to Exercise |
| Q26751078 | Using Drosophila to discover mechanisms underlying type 2 diabetes |
| Q35638974 | What can genetic studies of left ventricular mass tell us? |
| Q53094388 | [Cardiac pathologies and aging: lessons from a tiny heart]. |
| Q30493481 | d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila |
| Q36498682 | dFatp regulates nutrient distribution and long-term physiology in Drosophila |
| Q27329717 | dJun and Vri/dNFIL3 are major regulators of cardiac aging in Drosophila |
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