The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis

scientific article published on 6 February 2004

The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M400646200
P8608Fatcat IDrelease_vdjf6zf5i5fxjkil6sstdnptyy
P698PubMed publication ID14766742

P2093author name stringGregorio Gil
William M Pandak
Antonio del Castillo-Olivares
José A Campos
P2860cites workStructure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of intronsQ22008833
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptorsQ24290397
The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repressionQ24554362
CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase geneQ24654020
A unified nomenclature system for the nuclear receptor superfamilyQ28142509
The enzymes, regulation, and genetics of bile acid synthesisQ28204726
Alpha 1-fetoprotein transcription factor is required for the expression of sterol 12alpha -hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcriptionQ28375187
Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporterQ28513496
The alpha1-fetoprotein locus is activated by a nuclear receptor of the Drosophila FTZ-F1 familyQ28571516
Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovaryQ28579504
On the mechanism of bile acid inhibition of rat sterol 12α-hydroxylase gene (CYP8B1) transcription: roles of α-fetoprotein transcription factor and hepatocyte nuclear factor 4αQ29032141
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene deliveryQ29615235
A receptor-mediated pathway for cholesterol homeostasisQ29616158
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesisQ29617241
The mouse fetoprotein transcription factor (FTF) gene promoter is regulated by three GATA elements with tandem E box and Nkx motifs, and FTF in turn activates the Hnf3beta, Hnf4alpha, and Hnf1alpha gene promotersQ30644800
Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesisQ33566678
Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase transcriptionQ33786733
The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptorQ33944953
Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repressionQ34089245
Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.Q34198844
Cholesterol and bile acids regulate cholesterol 7 alpha-hydroxylase expression at the transcriptional level in culture and in transgenic mice.Q36651232
Structure of the mouse cholesterol 7 alpha-hydroxylase geneQ36740472
c-Myc target gene specificity is determined by a post-DNAbinding mechanismQ36808429
Differential effects of sterol regulatory binding proteins 1 and 2 on sterol 12 alpha-hydroxylase. SREBP-2 suppresses the sterol 12 alpha-hydroxylase promoterQ38293980
Coexamination of site-specific transcription factor binding and promoter activity in living cellsQ39449417
Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomersQ40941501
Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporterQ42511033
Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathwayQ43559873
The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated byQ43636951
Redundant pathways for negative feedback regulation of bile acid productionQ44025689
Suppression of cholesterol 7alpha-hydroxylase transcription and bile acid synthesis by an alpha1-antitrypsin peptide via interaction with alpha1-fetoprotein transcription factorQ44132516
Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytesQ44170609
Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycleQ44514694
Regulation of sterol 12alpha-hydroxylase and cholic acid biosynthesis in the rat.Q44869232
Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat.Q45108263
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)16813-16821
P577publication date2004-02-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis
P478volume279

Reverse relations

cites work (P2860)
Q24305147A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene
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Q34540006All-trans retinoic acid regulates hepatic bile acid homeostasis
Q42704943Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbits
Q27002873Bile acid metabolism and signaling
Q24658139Bile acids: regulation of synthesis
Q35670511Chenodeoxycholic Acid Reduces Hypoxia Inducible Factor-1α Protein and Its Target Genes
Q35641906Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism
Q36106015Elevated copper impairs hepatic nuclear receptor function in Wilson's disease
Q24293122Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue
Q38520051Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype
Q36983521Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27.
Q40068634Hepatocyte nuclear factor 1 alpha is a factor responsible for the interindividual variation of OATP1B1 mRNA levels in adult Japanese livers
Q34694228Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver
Q35148501Identification of transcription factors and single nucleotide polymorphisms of Lrh1 and its homologous genes in Lrh1-knockout pancreas of mice
Q51757951Impaired progesterone production in Nr5a2+/- mice leads to a reduction in female reproductive function.
Q40174330Interaction between sterol regulatory element-binding proteins and liver receptor homolog-1 reciprocally suppresses their transcriptional activities
Q57121222Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration
Q36693487Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
Q59797226Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases
Q36445376Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation
Q38626000Obeticholic acid, a selective farnesoid X receptor agonist, regulates bile acid homeostasis in sandwich-cultured human hepatocytes.
Q28587194Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development
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Q33678751alpha(1)-fetoprotein transcription factor (FTF)/liver receptor homolog-1 (LRH-1) is an essential lipogenic regulator

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