Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. intermediacy of H(2)O(2)- and p53-dependent pathways

scientific article published on 30 March 2004

Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. intermediacy of H(2)O(2)- and p53-dependent pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M400944200
P698PubMed publication ID15054096

P2093author name stringSuwei Wang
Joy Joseph
Srigiridhar Kotamraju
B Kalyanaraman
Eugene A Konorev
Shasi Kalivendi
P2860cites workNF-kappaB prevents cells from undergoing Cr(VI)-induced apoptosisQ23922085
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentationQ24642901
p53, the cellular gatekeeper for growth and divisionQ27860990
Mitochondria and apoptosisQ29547905
Caspases: killer proteasesQ29616315
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Fas-mediated apoptosis in adriamycin-induced cardiomyopathy in rats: In vivo studyQ31419232
Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Q33963311
ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3.Q34155654
Signaling pathways activated by daunorubicinQ34330164
Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitorsQ34369172
bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosisQ36040551
Cellular oxidative stress and the control of apoptosis by wild-type p53, cytotoxic compounds, and cytokinesQ37388228
Overexpression of manganese superoxide dismutase promotes survival in cell lines after doxorubicin treatmentQ40671365
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapyQ40929887
Redox regulation of transcriptional activatorsQ41150355
Phorbol esters attenuate the expression of p53 in cells treated with doxorubicin and protect TS-P53/K562 from apoptosis.Q41283160
Flow cytometric detection of hydrogen peroxide production induced by doxorubicin in cancer cellsQ41477992
The p53 networkQ41673584
Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxideQ41817128
Early and delayed clinical cardiotoxicity of doxorubicinQ42225832
Benzo[a]pyrene activates the human p53 gene through induction of nuclear factor kappaB activityQ42480361
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.Q43560472
GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complexQ43699858
Reactivity of mono-meso-substituted iron(II) octaethylporphyrin complexes with hydrogen peroxide in the absence of dioxygen. Evidence for nucleophilic attack on the hemeQ43804813
Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.Q43847020
Induction of apoptosis by chemotherapeutic drugs without generation of reactive oxygen speciesQ43857544
The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpartQ44295644
Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I.Q46627102
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectdoxorubicinQ18936
apoptotic processQ14599311
P304page(s)25535-25543
P577publication date2004-03-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleDoxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. intermediacy of H(2)O(2)- and p53-dependent pathways
P478volume279