Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons.

scientific article

Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/JNEUROSCI.0348-04.2004
P932PMC publication ID6729450
P698PubMed publication ID15128854

P50authorKenneth K. TengQ37378083
P2093author name stringBarbara L Hempstead
Zhe-Yu Chen
Francis S Lee
Paresh D Patel
Chui-Xiang Meng
Gayatree Sant
P2860cites workNeurotrophins: roles in neuronal development and functionQ24656166
Regulation of cell survival by secreted proneurotrophinsQ27919620
The granin (chromogranin/secretogranin) familyQ28284590
ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injuryQ28574864
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal functionQ29615582
Neurotrophins and their receptors: a convergence point for many signalling pathwaysQ29616108
BDNF and activity-dependent synaptic modulationQ33820669
Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorderQ33905209
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factorQ33932396
Activation of Trk neurotrophin receptors in the absence of neurotrophinsQ33937877
Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptorsQ34028643
Neurotrophins as synaptic modulatorsQ34186265
The granin family--its role in sorting and secretory granule formationQ34399146
Storage and release of acetylcholine by a clonal cell lineQ35062636
Pro-region of neurotrophins: role in synaptic modulationQ35209102
p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cellsQ35745844
Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injuryQ35796028
The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study.Q37219127
Neurotrophin-4, alone or heterodimerized with brain-derived neurotrophic factor, is sorted to the constitutive secretory pathwayQ40635192
Sorting and processing of secretory proteinsQ40744676
Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factorQ40832311
Characterization of a newly established human bone marrow endothelial cell line: distinct adhesive properties for hematopoietic progenitors compared with human umbilical vein endothelial cells.Q41142309
The regulated secretion and vectorial targeting of neurotrophins in neuroendocrine and epithelial cellsQ41159160
The biosynthesis of neurotrophin heterodimers by transfected mammalian cellsQ41344531
Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiationQ41596156
A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depressionQ42694857
Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neuronsQ43435250
Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampusQ43450226
Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphismsQ43849066
Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factorQ44078822
Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type.Q44531022
Coexpression of mRNAs for NGF, BDNF, and NT-3 in the cardiovascular system of the pre- and postnatal rat.Q45942456
Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance.Q47724311
Pleiotropic functions of neurotrophins in development.Q52184080
Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease.Q53246711
Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factorQ57042409
Selective role for trkB neurotrophin receptors in rapid modulation of hippocampal synaptic transmissionQ71501957
Expression of mRNAs for neurotrophins and their receptors in developing rat heartQ71720426
Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilizationQ73053921
NGF activates similar intracellular signaling pathways in vascular smooth muscle cells as PDGF-BB but elicits different biological responsesQ77297677
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectrs6265Q7375573
P304page(s)4401-4411
P577publication date2004-05-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleVariant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
P478volume24

Reverse relations

cites work (P2860)
Q37054137A Case-Control Study and Meta-Analysis Reveal BDNF Val66Met Is a Possible Risk Factor for PTSD.
Q64093272A Novel Peptide Interfering with proBDNF-Sortilin Interaction Alleviates Chronic Inflammatory Pain
Q48292334A brain-derived neurotrophic factor polymorphism Val66Met identifies fibromyalgia syndrome subgroup with higher body mass index and C-reactive protein
Q48182219A genotype-endophenotype-phenotype path model of depressed mood: integrating cognitive and emotional markers
Q35049949A neurogenetics approach to defining differential susceptibility to institutional care
Q34612732A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques
Q34148214A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors
Q35844099A review on experimental and clinical genetic associations studies on fear conditioning, extinction and cognitive-behavioral treatment
Q90248276A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia
Q42089818A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice
Q34099252A simple role for BDNF in learning and memory?
Q34344423A systematic review and meta-analysis on the association between BDNF val(66)met and hippocampal volume--a genuine effect or a winners curse?
Q45896767Acquisition and generalization of fear conditioning are not modulated by the BDNF-val66met polymorphism in humans
Q36637069Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF)
Q46604995Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Q37373464Activity-dependent dendritic release of BDNF and biological consequences.
Q50584031Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy.
Q47262957Adolescent Corticosterone and TrkB Pharmaco-Manipulations Sex-Dependently Impact Instrumental Reversal Learning Later in Life
Q37245271Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers.
Q37465593Altered Episodic Memory in Introverted Young Adults Carrying the BDNFMet Allele
Q30477199Amygdala-dependent fear conditioning in humans is modulated by the BDNFval66met polymorphism.
Q45917874An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5-HTTLPR, and MTHFR genes in older Korean men.
Q35034804Analyzing the influence of BDNF heterozygosity on spatial memory response to 17β-estradiol
Q45922559Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in Borderline personality disorder.
Q48473268Association between BDNF polymorphism (Val66Met) and executive function in patients with amnestic mild cognitive impairment or mild Alzheimer disease
Q36528457Association between BDNF rs6265 and obesity in the Boston Puerto Rican Health Study
Q48958164Association between C-281A and val66met functional polymorphisms of BDNF gene and risk of recurrent major depressive disorder in Polish population
Q35225338Association between DNA Methylation of the BDNF Promoter Region and Clinical Presentation in Alzheimer's Disease.
Q34085837Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence
Q46840112Association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and executive function in Japanese patients with Alzheimer's disease
Q34706991Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia
Q47909466Association between genes, stressful childhood events and processing bias in depression vulnerable individuals
Q60620014Association between the brain-derived neurotrophic factor Val66Met polymorphism and therapeutic response to olanzapine in schizophrenia patients
Q50061520Association of BDNF Val66Met Polymorphism and Brain BDNF levels with Major Depression and Suicide
Q34523157Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress
Q90013519Association of BDNF rs6265 and MC4R rs17782313 with metabolic syndrome in Pakistanis
Q42927243Association of brain-derived neurotrophic factor (Val66Met) genetic polymorphism with methamphetamine dependence in a Malaysian population
Q35186571Association of functional polymorphisms from brain-derived neurotrophic factor and serotonin-related genes with depressive symptoms after a medical stressor in older adults
Q49025094Association of the BDNF Val66Met variation with obesity in women.
Q51034231Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms.
Q64085334BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury
Q36906438BDNF Genotype Interacts with Motor Function to Influence Rehabilitation Responsiveness Poststroke
Q37310834BDNF Val(66)Met Polymorphism Influences Visuomotor Associative Learning and the Sensitivity to Action Observation
Q35987786BDNF Val(66)Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: a pilot study
Q91583675BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes
Q35931426BDNF Val66Met Polymorphism Is Associated with Self-Reported Empathy.
Q92537291BDNF Val66Met Positive Players Demonstrate Diffusion Tensor Imaging Consistent With Impaired Myelination Associated With High Levels of Soccer Heading: Indication of a Potential Gene-Environment Interaction Mechanism
Q35713564BDNF Val66Met and cognition: all, none, or some? A meta-analysis of the genetic association
Q34233144BDNF Val66Met genotype and 6-month remission rates in late-life depression
Q35837743BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity
Q61651981BDNF Val66Met polymorphism and brain volumes in multiple sclerosis
Q57160899BDNF Val66Met polymorphism and clinical response to antipsychotic treatment in schizophrenia and schizoaffective disorder patients: a meta-analysis
Q33530233BDNF Val66Met polymorphism and protein levels in amniotic fluid
Q36405986BDNF Val66Met polymorphism interacts with sex to influence bimanual motor control in healthy humans
Q33614257BDNF Val66Met polymorphism, energy intake and BMI: a follow-up study in schoolchildren at risk of eating disorders
Q38625092BDNF Val66Met variant and age of onset in schizophrenia.
Q34535122BDNF Val66Met variant and smoking in a Chinese population
Q48024639BDNF and LTP-/LTD-like plasticity of the primary motor cortex in Gilles de la Tourette syndrome
Q43802974BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment
Q36950532BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.
Q37450600BDNF genotype modulates resting functional connectivity in children
Q38831821BDNF isoforms: a round trip ticket between neurogenesis and serotonin?
Q34115242BDNF modulates contextual fear learning during adolescence
Q64819678BDNF provides many routes toward STN DBS-mediated disease modification
Q35203597BDNF release is required for the behavioral actions of ketamine
Q38166455BDNF rs6265 polymorphism and drug addiction: a systematic review and meta-analysis
Q57799313BDNF rs6265 polymorphism methylation in Multiple Sclerosis: A possible marker of disease progression
Q37602560BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses.
Q42517523BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors.
Q35844321BDNF val66met affects hippocampal volume and emotion-related hippocampal memory activity
Q33992471BDNF val66met polymorphism, white matter abnormalities and remission of geriatric depression
Q33733000BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function
Q33854887BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study
Q42475620BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects
Q47958150BDNF, relative preference, and reward circuitry responses to emotional communication
Q36589545BDNF-TrkB signaling and neuroprotection in schizophrenia
Q38670024BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity.
Q48322989Biology trumps statistics in the postgenomic era.
Q34364063Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology
Q34110230Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding.
Q24647109Brain foods: the effects of nutrients on brain function
Q37594329Brain plasticity and genetic factors
Q36279804Brain-Derived Neurotrophic Factor (BDNF) in Traumatic Brain Injury-Related Mortality: Interrelationships Between Genetics and Acute Systemic and Central Nervous System BDNF Profiles
Q41769724Brain-Derived Neurotrophic Factor (Val66Met) and Serotonin Transporter (5-HTTLPR) Polymorphisms Modulate Plasticity in Inhibitory Control Performance Over Time but Independent of Inhibitory Control Training
Q48099455Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism and Risk of Schizophrenia: A Meta-analysis of Case-Control Studies
Q33619386Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism Impacts on Migraine Susceptibility: A Meta-analysis of Case-Control Studies
Q39896459Brain-Derived Neurotrophic Factor Val66Met Polymorphism Affects the Relationship Between an Anxiety-Related Personality Trait and Resting Regional Cerebral Blood Flow
Q41452493Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection.
Q26795382Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions
Q37113505Brain-derived neurotrophic factor (Val66Met) polymorphism and olfactory ability in young adults
Q36349176Brain-derived neurotrophic factor Val(66)Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study
Q34061150Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex
Q38564467Brain-derived neurotrophic factor Val66Met polymorphism, human memory, and synaptic neuroplasticity.
Q35995934Brain-derived neurotrophic factor Val⁶⁶Met polymorphism affects resting regional cerebral blood flow and functional connectivity differentially in women versus men
Q37003649Brain-derived neurotrophic factor and suicide pathogenesis
Q45984035Brain-derived neurotrophic factor gene polymorphisms and mirtazapine responses in Koreans with major depression.
Q48536488Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder
Q34075816Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individuals
Q34815106Brain-derived neurotrophic factor in chronic periodontitis.
Q98733449Brain-derived neurotrophic factor polymorphism Val66Met protects against cancer-related fatigue
Q52647021Brain-derived neurotrophic factor secreted by the cerebral endothelium: A new actor of brain function?
Q24647110Brain-derived neurotrophic factor: role in depression and suicide
Q51875231Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology.
Q36047812Bridging animal and human models of exercise-induced brain plasticity
Q22252698Candidate gene studies of ADHD: a meta-analytic review
Q34987347Cell biology of BDNF and its relevance to schizophrenia
Q39663375Characterization of the intracellular localization, processing, and secretion of two glial cell line-derived neurotrophic factor splice isoforms.
Q26824841Charcot-Marie-Tooth disease and intracellular traffic
Q48258812Chronic duloxetine treatment induces specific changes in the expression of BDNF transcripts and in the subcellular localization of the neurotrophin protein
Q38936602Clinical and genetic factors associated with suicide in mood disorder patients
Q49709684Cognition, serum BDNF levels, and BDNF Val66Met polymorphism in type 2 diabetes patients and healthy controls
Q34726039Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers
Q36900676Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls.
Q92615784Conditioned taste aversion memory extinction temporally induces insular cortical BDNF release and inhibits neuronal apoptosis
Q34410506Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent
Q38112245DNA methylation of the BDNF gene and its relevance to psychiatric disorders
Q45210021Decreased serum levels of brain-derived neurotrophic factor in adults with attention-deficit hyperactivity disorder.
Q34588289Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases.
Q34159085Dendritic spine dysgenesis in Rett syndrome.
Q34630493Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms
Q48066589Depression in multiple sclerosis: effect of brain derived neurotrophic factor Val66Met polymorphism and disease perception.
Q24814359Difference in trafficking of brain-derived neurotrophic factor between axons and dendrites of cortical neurons, revealed by live-cell imaging
Q57892206Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats
Q48332729Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?
Q38649157Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?
Q50860874Dosage effects of BDNF Val66Met polymorphism on cortical surface area and functional connectivity.
Q47890256Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression
Q34295880Dynamic plasticity: the role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors
Q37171338Effect of BDNF val66met polymorphism on age-related amygdala volume changes in healthy subjects
Q47287966Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice
Q37388278Effect of childhood maltreatment and brain-derived neurotrophic factor on brain morphology
Q48468708Effect of the BDNF V166M polymorphism on working memory in healthy adolescents
Q43284373Effects of brain-derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia
Q60907438Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism
Q57316782Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia
Q33723741Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder
Q30491898Efficient copackaging and cotransport yields postsynaptic colocalization of neuromodulators associated with synaptic plasticity
Q43245777Emotional distress in parents of psychotic patients is modified by serotonin transporter gene (5-HTTLPR)--brain-derived neurotrophic factor gene interactions.
Q38039966Endophenotypes as a measure of suicidality
Q36279126Environmental and pharmacological modulations of cellular plasticity: role in the pathophysiology and treatment of depression
Q61447842Epistasis of HTR1A and BDNF risk genes alters cortical 5-HT1A receptor binding: PET results link genotype to molecular phenotype in depression
Q39863109Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1.
Q39412337Estrogens and the cognitive symptoms of schizophrenia: Possible neuroprotective mechanisms
Q30490427Ethanol-BDNF interactions: still more questions than answers.
Q37123304Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder
Q26991898Exercise, neurotrophins, and axon regeneration in the PNS
Q34134231Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding
Q36074354Fear extinction and BDNF: translating animal models of PTSD to the clinic
Q36327926Functional polymorphisms in dopamine and serotonin pathway genes
Q92491415Future considerations for pediatric cancer survivorship: Translational perspectives from developmental neuroscience
Q36668325GABAergic control of depression-related brain states
Q30462711GDNF and BDNF gene interplay in chronic tinnitus
Q35877933Gender, brain-derived neurotrophic factor Val66Met, and frequency of methamphetamine use
Q48401183Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies
Q34497567Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder
Q59807422Genetic Variants of the Brain-Derived Neurotrophic Factor and Metabolic Indices in Veterans With Posttraumatic Stress Disorder
Q34704748Genetic and behavioral determinants of hippocampal volume recovery during abstinence from alcohol.
Q36947139Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms
Q36328154Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo
Q38755102Genetic risk factors for cognitive decline in Parkinson's disease: a review of the literature
Q24679793Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Q35840890Genetic variant of BDNF (Val66Met) polymorphism attenuates stroke-induced angiogenic responses by enhancing anti-angiogenic mediator CD36 expression
Q47835465Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis
Q37004788Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease
Q34627311Genetic variation at the BDNF locus: evidence for association with long-term outcome after ischemic stroke
Q30417488Genetic variation in brain-derived neurotrophic factor and human fear conditioning
Q37088174Genetics as a molecular window into recovery, its treatment, and stress responses after stroke
Q34139876Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence
Q42413380Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR.
Q51833459Glatiramer acetate (GA, Copolymer-1) an hypothetical treatment option for Rett syndrome
Q39144437Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain.
Q37118169HIV-1 decreases the levels of neurotrophins in human lymphocytes
Q47602590Harsh Parenting and Serotonin Transporter and BDNF Val66Met Polymorphisms as Predictors of Adolescent Depressive Symptoms.
Q37708292High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons.
Q30478015Hippocampal neurons recycle BDNF for activity-dependent secretion and LTP maintenance.
Q46301222Human BDNF isoforms are differentially expressed in cocaine addicts and are sorted to the regulated secretory pathway independent of the Met66 substitution
Q96131640Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities
Q28569078Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release
Q36700576Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene
Q28538189Identification of BDNF sensitive electrophysiological markers of synaptic activity and their structural correlates in healthy subjects using a genetic approach utilizing the functional BDNF Val66Met polymorphism
Q24644115Identification of pro- and mature brain-derived neurotrophic factor in human saliva
Q56768819Imaging genetics paradigms in depression research: Systematic review and meta-analysis
Q47871481Immediate-Early Genes Modulation by Antipsychotics: Translational Implications for a Putative Gateway to Drug-Induced Long-Term Brain Changes.
Q48105544Immunolocalization of pro- and mature-brain derived neurotrophic factor (BDNF) and receptor TrkB in the human brainstem and hippocampus
Q48315602Impact of BDNF -196 G>A and BDNF -270 C>T polymorphisms on stroke rehabilitation outcome: sex and age differences.
Q36845697Impact of BDNF Val66Met and 5-HTTLPR polymorphism variants on neural substrates related to sadness and executive function.
Q48189916Impact of BDNF Val66Met polymorphism on olfactory functions of female concussed athletes
Q37170569Impact of genetic variant BDNF (Val66Met) on brain structure and function
Q30460375Impact of the BDNF Val66Met polymorphism on cognition: implications for behavioral genetics
Q36981190Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla
Q47248581Impaired cognitive flexibility during sleep deprivation among carriers of the Brain Derived Neurotrophic Factor (BDNF) Val66Met allele
Q64103534In silico analysis of the V66M variant of human BDNF in psychiatric disorders: An approach to precision medicine
Q37072952Influence of BDNF polymorphisms on Wilson's disease susceptibility and clinical course
Q35058421Influence of brain-derived neurotrophic factor and apolipoprotein E genetic variants on hemispheric and lateral ventricular volume of young healthy adults
Q33653447Interaction between 5-HTTLPR and BDNF Val66Met polymorphisms on HPA axis reactivity in preschoolers
Q46990510Interaction between BDNF Val66Met and childhood trauma on adult's violent suicide attempt.
Q48225401Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits.
Q48451564Interaction between catechol-O-methyltransferase (COMT) Val108/158Met and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in age at onset and clinical symptoms in schizophrenia
Q36288923Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women
Q48812755Interaction of COMT rs4680 and BDNF rs6265 polymorphisms on functional connectivity density of the left frontal eye field in healthy young adults
Q59791825Interactions of Val66Met Polymorphism and Menstrual Pain on Brain Complexity
Q35236607Intermediate phenotypes in schizophrenia: a selective review.
Q26781504Interrelation between Neuroendocrine Disturbances and Medical Complications Encountered during Rehabilitation after TBI
Q51819405Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells.
Q45796300Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine
Q44264783Involvement of BDNF signaling transmission from basolateral amygdala to infralimbic prefrontal cortex in conditioned taste aversion extinction.
Q37156921Involvement of brain-derived neurotrophic factor in late-life depression
Q38674655Is the Val66Met polymorphism of the brain-derived neurotrophic factor gene associated with panic disorder? A meta-analysis
Q26828564Ketamine, sleep, and depression: current status and new questions
Q47615913Ketamine-Induced Glutamatergic Mechanisms of Sleep and Wakefulness: Insights for Developing Novel Treatments for Disturbed Sleep and Mood.
Q35929042Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory
Q41050624Loneliness in Relation to Depression: The Moderating Influence of a Polymorphism of the Brain Derived Neurotrophic Factor Gene on Self-efficacy and Coping Strategies
Q47271759Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point?
Q36749816Low-Level Stress Induces Production of Neuroprotective Factors in Wild-Type but Not BDNF+/- Mice: Interleukin-10 and Kynurenic Acid
Q37509863Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome
Q38784077Mechanisms of the placebo effect in pain and psychiatric disorders
Q40036871Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity
Q40390647Meta-analysis of the association of brain-derived neurotrophic factor Val66Met polymorphism with obsessive-compulsive disorder.
Q37460218Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: fundamental roles in neurodevelopmental disorders associated with mental retardation and autism
Q37776087Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
Q26766487Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders
Q38904980Molecular mechanisms underlying alcohol-drinking behaviours
Q48852306Morphological properties of the action-observation cortical network in adolescents with low and high resistance to peer influence
Q38020487Multiple approaches to investigate the transport and activity-dependent release of BDNF and their application in neurogenetic disorders
Q40199654Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism.
Q90316534N-Glycosylation is required for secretion of the precursor to brain-derived neurotrophic factor (proBDNF) carrying sulfated LacdiNAc structures
Q33708741Neurobiology of local and intercellular BDNF signaling
Q38435480Neuronal correlates of brain-derived neurotrophic factor Val66Met polymorphism and morphometric abnormalities in bipolar disorder.
Q46946716Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders
Q37781350Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects.
Q36983344Neurotrophic factor control of satiety and body weight
Q38999345Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy
Q38068714Neurotrophin regulation of neural circuit development and function
Q36011413Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions
Q39183381Neurotrophins and Proneurotrophins
Q36697163No association between BDNF Val66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population
Q37049608No association of genetic variants in BDNF with major depression: a meta- and gene-based analysis
Q38403023On the Run for Hippocampal Plasticity
Q48576876Overexpression of plasminogen activators in the nucleus accumbens enhances cocaine-, amphetamine- and morphine-induced reward and behavioral sensitization
Q34015158Paradoxical visuomotor adaptation to reversed visual input is predicted by BDNF Val66Met polymorphism
Q33695338Parental brain-derived neurotrophic factor genotype, child prosociality, and their interaction as predictors of parents' warmth
Q35752084Pathways Mediating Activity-Induced Enhancement of Recovery From Peripheral Nerve Injury
Q51829038Performance-related increases in hippocampal N-acetylaspartate (NAA) induced by spatial navigation training are restricted to BDNF Val homozygotes.
Q46903587Peripheral levels of BDNF and NGF in primary headaches
Q52146500Peripheral vascular reactivity and serum BDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism.
Q38103882Pharmacogenetic considerations for late life depression therapy
Q46852529Pharmacogenetics of neural injury recovery
Q37969219Pharmacogenetics of obsessive-compulsive disorders
Q30454454Physical exercise during encoding improves vocabulary learning in young female adults: a neuroendocrinological study
Q45777016Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease.
Q37184490Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein E ε4 carriers
Q33926241Population genetic study of the brain-derived neurotrophic factor (BDNF) gene
Q31035766Postpartum depressive symptoms and the BDNF Val66Met functional polymorphism: effect of season of delivery.
Q28573496Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing
Q36063778Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment.
Q93379630Prefrontal cortical trkB, glucocorticoids, and their interactions in stress and developmental contexts
Q36578272Preliminary Associations Between Brain-Derived Neurotrophic Factor, Memory Impairment, Functional Cognition, and Depressive Symptoms Following Severe TBI.
Q90695436Prenatal intimate partner violence exposure predicts infant biobehavioral regulation: Moderation by the brain-derived neurotrophic factor (BDNF) gene
Q21132321Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor
Q37051564Preventing the Return of Fear Using Reconsolidation Update Mechanisms Depends on the Met-Allele of the Brain Derived Neurotrophic Factor Val66Met Polymorphism.
Q40414334ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.
Q38125896Promoting neuroplasticity for motor rehabilitation after stroke: considering the effects of aerobic exercise and genetic variation on brain-derived neurotrophic factor
Q48091762Proportional recovery after stroke depends on corticomotor integrity
Q38776707Protection of Cultured Dopamine Neurons from MPP(+) Requires a Combination of Neurotrophic Factors
Q38187948Psychopharmacological treatment of neurocognitive deficits in people with schizophrenia: a review of old and new targets
Q37076456Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction
Q24614410Rapid antidepressant effects: moving right along
Q41949286Reduced severity of posttraumatic stress disorder associated with Val allele of Val66Met polymorphism at brain-derived neurotrophic factor gene among Chinese adolescents after Wenchuan earthquake
Q30498250Region-specific involvement of BDNF secretion and synthesis in conditioned taste aversion memory formation
Q37225360Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway
Q58721314Relevance of polymorphisms in MC4R and BDNF in short normal stature
Q93138938Role of BDNF in the development of an OFC-amygdala circuit regulating sociability in mouse and human
Q90324876Role of a VGF/BDNF/TrkB Autoregulatory Feedback Loop in Rapid-Acting Antidepressant Efficacy
Q37024497Role of the brain-derived neurotrophic factor at glutamatergic synapses.
Q46952807Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Q34024804SNP rs6265 regulates protein phosphorylation and osteoblast differentiation and influences BMD in humans
Q48207060Screening for genetic variants in BDNF that contribute to childhood obesity
Q61810732Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients
Q92243847Serbian Twin Registry
Q51286658Serum Brain-Derived Neurotrophic Factor Mediates the Relationship between Abdominal Adiposity and Executive Function in Middle Age.
Q37213551Shaping neurons: Long and short range effects of mature and proBDNF signalling upon neuronal structure
Q37923872Signaling pathways mediating alcohol effects.
Q55001611Significant association of BDNF rs6265 G>A polymorphism with susceptibility to epilepsy: a meta-analysis.
Q24532072Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.
Q35842258Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor
Q51873814Study on the possible association of brain-derived neurotrophic factor polymorphism with the developmental course of symptoms of attention deficit and hyperactivity.
Q38728935Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration.
Q38831859Synaptic alterations associated with depression and schizophrenia: potential as a therapeutic target
Q55133068Targeting the intracellular signaling "STOP" and "GO" pathways for the treatment of alcohol use disorders.
Q48244608The BDNF Val(66)Met polymorphism is associated with escitalopram response in depressed patients
Q90693896The BDNF Val66Met Polymorphism Modulates Resilience of Neurological Functioning to Brain Ageing and Dementia: A Narrative Review
Q89128873The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior
Q41223158The BDNF Val66Met variant affects gene expression through miR-146b
Q41554744The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation.
Q91666508The BDNF gene val66met polymorphism and behavioral inhibition in early childhood
Q40999723The BDNF val-66-met Polymorphism Affects Neuronal Morphology and Synaptic Transmission in Cultured Hippocampal Neurons from Rett Syndrome Mice.
Q53692090The Genetics of Treatment-Resistant Depression: A Critical Review and Future Perspectives.
Q35638019The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus.
Q90351901The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese Older Adults
Q38263681The Physiology of BDNF and Its Relationship with ADHD.
Q61449132The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met
Q28074012The Role of BDNF in the Development of Fear Learning
Q47140989The association between gene variants and longitudinal structural brain changes in psychosis: a systematic review of longitudinal neuroimaging genetics studies
Q35959765The brain-derived neurotrophic factor (BDNF) val66met polymorphism differentially affects performance on subscales of the Wechsler Memory Scale - Third Edition (WMS-III).
Q33833981The brain-derived neurotrophic factor Val66Met polymorphism affects encoding of object locations during active navigation.
Q48667441The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills
Q51935722The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.
Q36547467The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis
Q24650396The common BDNF polymorphism may be a modifier of disease severity in Rett syndrome
Q37952822The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression.
Q28259199The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009
Q48216757The influence of high intensity exercise and the Val66Met polymorphism on circulating BDNF and locomotor learning
Q35576180The influences of diet and exercise on mental health through hormesis
Q48561637The interaction between BDNF and DRD2 in bipolar II disorder but not in bipolar I disorder
Q93079659The interplay of polygenic plasticity and adrenocortical activity as sources of variability in pathways among family adversity, youth emotional reactivity, and psychological problems
Q35801796The lighter side of BDNF.
Q21195685The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice
Q24649251The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism
Q36818579The presence of a single-nucleotide polymorphism in the BDNF gene affects the rate of locomotor adaptation after stroke
Q52685713The relationship between BDNF Val66Met polymorphism and functional mobility in chronic stroke survivors.
Q37344077The requirement of BDNF for hippocampal synaptic plasticity is experience-dependent
Q37729843The role of BDNF in depression on the basis of its location in the neural circuitry
Q90738818The role of BDNF methylation and Val66 Met in amygdala reactivity during emotion processing
Q35871363The role of brain-derived neurotrophic factor genotype, parental depression, and relationship discord in predicting early-emerging negative emotionality
Q47267712The role of genetic variability in the SLC6A4, BDNF and GABRA6 genes in anxiety-related traits.
Q91938787The role of genetics in cognitive remediation in schizophrenia: A systematic review
Q35369290The role of the Met66 brain-derived neurotrophic factor allele in the recovery of executive functioning after combat-related traumatic brain injury
Q34897934The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
Q37139503The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: associations with cognitive vulnerability to depression in childhood
Q37274645The skinny on brain-derived neurotrophic factor: evidence from animal models to GWAS.
Q34439423The yin and yang of neurotrophin action
Q34383112Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking.
Q38484760Transcriptome profiling analysis of the mechanisms underlying the BDNF Val66Met polymorphism induced dysfunctions of the central nervous system
Q46654662Val66Met BDNF genotypes in melancholic depression: effects on brain structure and treatment outcome.
Q58586784Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females
Q48874582Val66Met polymorphism and serum brain-derived neurotrophic factor concentration in depressed patients
Q37287082Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction
Q37717633Valence-specific effects of BDNF Val66Met polymorphism on dopaminergic stress and reward processing in humans
Q33997931Variant BDNF (Val66Met) impact on brain structure and function
Q35870094Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants
Q35009192Variation in the BDNF gene interacts with age to predict mortality in a prospective, longitudinal cohort with severe TBI.
Q26864720Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders
Q36358072What is the biological significance of BDNF mRNA targeting in the dendrites? Clues from epilepsy and cortical development
Q59340509proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing
Q61819760‘Two Hit’ Neurodevelopmental Mechanisms in Schizophrenia: Focus on Animal Models and the Role of BDNF

Search more.