Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression

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Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PMIC.201600057
P932PMC publication ID5462625
P698PubMed publication ID27718298

P50authorMarla GearingQ67212581
Madhav ThambisettyQ71775824
P2093author name stringAllan I Levey
Duc M Duong
Nicholas T Seyfried
Eric B Dammer
James J Lah
Juan C Troncoso
Joshua M Shulman
Chadwick M Hales
Qiudong Deng
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Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillizationQ28588090
Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometryQ29547311
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Amyloid deposition as the central event in the aetiology of Alzheimer's diseaseQ29619450
Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathyQ30574960
Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisitionQ30800087
U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21.Q33616573
Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease.Q33745920
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Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.Q34473854
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and ToxicityQ34525808
Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer diseaseQ34737880
Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins.Q35498406
A yeast functional screen predicts new candidate ALS disease genesQ35641365
Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease.Q35917235
Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standardsQ35975425
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ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule FunctionQ36320469
Evaluation of annexin A5 as a biomarker for Alzheimer's disease and dementia with lewy bodiesQ36742691
The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individualsQ37090083
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U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's diseaseQ37236333
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Tau pathology and neurodegenerationQ38107632
Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment StudiesQ38841875
Association of frailty with the serine protease HtrA1 in older adults.Q38883957
Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitorsQ39035111
Alzheimer's Aβ interacts with cellular prion protein inducing neuronal membrane damage and synaptotoxicityQ39054487
Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's diseaseQ40573179
Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicityQ41186950
Systematical optimization of reverse-phase chromatography for shotgun proteomicsQ42068281
Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregatesQ42201998
Fast R Functions for Robust Correlations and Hierarchical ClusteringQ42239626
Neuron enriched nuclear proteome isolated from human brain.Q42539702
Serum amyloid P immunoreactivity in hippocampal tangles, plaques and vessels: implications for leakage across the blood-brain barrier in Alzheimer's diseaseQ43457313
Progressive infantile neurodegeneration caused by 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency: a novel inborn error of branched-chain fatty acid and isoleucine metabolismQ43511079
Ribosome dysfunction is an early event in Alzheimer's disease.Q46738279
P4510describes a project that usesCytoscapeQ3699942
ggplot2Q326489
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)3042-3053
P577publication date2016-10-08
P1433published inProteomicsQ15614164
P1476titleChanges in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression
P478volume16

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cites work (P2860)
Q90146931Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models
Q91045286Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease
Q64949212Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.
Q47395290Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.
Q93047281Deep Profiling of the Aggregated Proteome in Alzheimer's Disease: From Pathology to Disease Mechanisms
Q57029721Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
Q47351811Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons.
Q98939496Development and validation of a six-RNA binding proteins prognostic signature and candidate drugs for prostate cancer
Q47384845Enrichment of Detergent-insoluble Protein Aggregates from Human Postmortem Brain
Q92387684Identification of molecular signatures and pathways to identify novel therapeutic targets in Alzheimer's disease: Insights from a systems biomedicine perspective
Q50420333Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.
Q88867119RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease
Q99212853Systems-based proteomics to resolve the biology of Alzheimer's disease beyond amyloid and tau

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