Hepatobiliary transporters: from genomics to diseases

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Hepatobiliary transporters: from genomics to diseases is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0399-8320(04)94995-0
P698PubMed publication ID15213671

P2093author name stringOlivier Rosmorduc
Raoul Poupon
P2860cites workCystic fibrosis transmembrane conductance regulator (CFTR) gene defects in patients with primary sclerosing cholangitisQ74485494
Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the ratQ77308908
Identification of a nuclear receptor for bile acidsQ22010058
FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyteQ24291838
Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterolQ24306058
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicityQ24630723
The molecular genetics of familial intrahepatic cholestasisQ24670001
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptorQ24683260
Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasisQ28139039
Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and managementQ28141076
Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein traffickingQ28142016
A unified nomenclature system for the nuclear receptor superfamilyQ28142509
Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndromeQ28143088
Differential Modulation of the Human Liver Conjugate Transporters MRP2 and MRP3 by Bile Acids and Organic AnionsQ28155855
The orphan nuclear receptor SXR coordinately regulates drug metabolism and effluxQ28186424
Nuclear receptor minireview seriesQ28207308
BSEP: function and role in progressive familial intrahepatic cholestasisQ28211441
Role of multidrug resistance 3 deficiency in pediatric and adult liver disease: one gene for three diseasesQ28211448
The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthoodQ28213549
MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasisQ28213568
A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndromeQ28240926
A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study GroupQ28243457
Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activityQ28247292
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alphaQ28273937
Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancyQ28295646
Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDLQ28354252
Biliary lipid composition in cholesterol microlithiasisQ28362634
Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species productionQ28379482
Nuclear receptors and lipid physiology: opening the X-filesQ29619362
Genetic basis of progressive familial intrahepatic cholestasisQ33715915
Molecular alterations in hepatocyte transport mechanisms in acquired cholestatic liver disordersQ34081640
Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasisQ34118792
Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisitedQ34146325
Bile salt transporters: molecular characterization, function, and regulationQ34186800
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretionQ34415865
FIC1 disease: a spectrum of intrahepatic cholestatic disordersQ34464148
Bile salt transportersQ34516267
Mechanisms of hepatic transport of drugs: implications for cholestatic drug reactionsQ34643082
Nuclear receptor regulation of hepatic functionQ34666809
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.Q34732527
Biliary cholesterol secretion by the twinned sterol half-transporters ABCG5 and ABCG8Q34796390
Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug dispositionQ34983639
A second heterozygous MDR3 nonsense mutation associated with intrahepatic cholestasis of pregnancyQ35441702
Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancyQ35595748
A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbationQ37383640
Involvement of multidrug resistance proteins (MDR) in the modulation of glucocorticoid responseQ38357628
Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and childrenQ40457634
Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.Q40785589
Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosisQ40883127
Etiologic significance of defects in cholesterol, phospholipid, and bile acid metabolism in the liver of patients with intrahepatic calculiQ43601204
Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liverQ43601206
Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in ratsQ43697146
Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pumpQ43899918
Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1.Q44053787
ATP binding cassette G5 C1950G polymorphism may affect blood cholesterol concentrations in humans.Q44130745
Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangiolesQ44165186
Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndromeQ44190773
Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirementQ44255121
Comparison of the intestinal uptake of cholesterol, plant sterols, and stanols in miceQ44299999
Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activityQ44381534
A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosisQ44387840
ABCB4 gene mutation-associated cholelithiasis in adultsQ44532958
Spontaneous cholecysto- and hepatolithiasis in Mdr2-/- mice: a model for low phospholipid-associated cholelithiasis.Q44749286
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.Q52541251
Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases.Q54017726
Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group.Q54118475
Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.Q54198574
Molecular pathogenesis of cholestasis.Q54344101
Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy responseQ57259756
Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1Q57840857
Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?Q69896715
Effect of obstructive jaundice on the regulation of hepatic cholesterol metabolism in the rat. Disappearance of abcg5 and abcg8 mRNA after bile duct ligationQ73143394
Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumorsQ74381357
P433issue5 Suppl
P407language of work or nameFrenchQ150
P921main subjectgenomicsQ222046
P304page(s)D112-20
P577publication date2004-05-01
P1433published inGastroenterologie Clinique et BiologiqueQ15756157
P1476titleHepatobiliary transporters: from genomics to diseases
P478volume28

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