Multiple myeloma: 2013 update on diagnosis, risk-stratification, and management

scientific article published in March 2013

Multiple myeloma: 2013 update on diagnosis, risk-stratification, and management is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/AJH.23390
P698PubMed publication ID23440663

P2093author name stringS Vincent Rajkumar
P2860cites workA long-term study of prognosis in monoclonal gammopathy of undetermined significance.Q55035699
Prospective, randomized study of single compared with double autologous stem-cell transplantation for multiple myeloma: Bologna 96 clinical studyQ56995088
Aspirin or enoxaparin thromboprophylaxis for patients with newly diagnosed multiple myeloma treated with lenalidomideQ57903992
Aspirin, Warfarin, or Enoxaparin Thromboprophylaxis in Patients With Multiple Myeloma Treated With Thalidomide: A Phase III, Open-Label, Randomized TrialQ57904015
Redefining myelomaQ58030074
Clinical Course and Prognosis of Smoldering (Asymptomatic) Multiple MyelomaQ58050813
Lenalidomide Maintenance after Stem-Cell Transplantation for Multiple MyelomaQ58415969
Identification of a primary target of thalidomide teratogenicityQ24302178
Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myelomaQ24605861
Criteria for diagnosis, staging, risk stratification and response assessment of multiple myelomaQ24647620
Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective studyQ24653006
Multiple myelomaQ24655964
Cancer statistics, 2012Q27860574
Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working GroupQ28207984
International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple MyelomaQ28243968
Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trialQ28252396
Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trialQ30433139
Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progressionQ33376149
Lenalidomide plus dexamethasone for relapsed or refractory multiple myelomaQ33377526
Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myelomaQ33386052
Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myelomaQ33386405
Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myelomaQ33389111
Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM).Q33391803
Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority studyQ33394981
A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myelomaQ33401596
A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myelomaQ33402536
Solitary plasmacytoma of bone and extramedullary plasmacytomaQ33811600
Antitumor activity of thalidomide in refractory multiple myelomaQ33880642
Superior results of Total Therapy 3 (2003-33) in gene expression profiling-defined low-risk multiple myeloma confirmed in subsequent trial 2006-66 with VRD maintenanceQ33887470
Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trialsQ33931651
Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group studyQ33942495
A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survivalQ33957196
Prevalence and risk of progression of light-chain monoclonal gammopathy of undetermined significance: a retrospective population-based cohort studyQ33997173
POEMS syndromeQ34006873
An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myelomaQ34008600
Total Therapy 3 for multiple myeloma: prognostic implications of cumulative dosing and premature discontinuation of VTD maintenance components, bortezomib, thalidomide, and dexamethasone, relevant to all phases of therapyQ34122646
POEMS syndrome: definitions and long-term outcomeQ34161383
High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myelomaQ34195428
Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.Q34210005
International Myeloma Working Group molecular classification of multiple myeloma: spotlight review.Q34241661
Lenalidomide after stem-cell transplantation for multiple myelomaQ34273726
Incidence of multiple myeloma in Olmsted County, Minnesota: Trend over 6 decadesQ34358438
Multiple myeloma.Q34362643
International staging system for multiple myelomaQ34408882
Phase III study of the value of thalidomide added to melphalan plus prednisone in elderly patients with newly diagnosed multiple myeloma: the HOVON 49 StudyQ43048164
Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myelomaQ43071494
Stem cell collection in patients with de novo multiple myeloma treated with the combination of bortezomib and dexamethasone before autologous stem cell transplantation according to IFM 2005-01 trial.Q43081275
Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: updated follow-up and impact of subsequent therapy in the phase III VISTA trialQ43109172
High-dose therapy intensification compared with continued standard chemotherapy in multiple myeloma patients responding to the initial chemotherapy: long-term results from a prospective randomized trial from the Spanish cooperative group PETHEMA.Q43573096
Prognostic validation of the international classification of immunoglobulin M gammopathies: a survival advantage for patients with immunoglobulin M monoclonal gammopathy of undetermined significance?Q43824187
Melphalan and prednisone versus melphalan, prednisone and thalidomide for elderly and/or transplant ineligible patients with multiple myeloma: a meta-analysisQ44190664
Immunoglobulin M monoclonal gammopathies of undetermined significance and indolent Waldenstrom's macroglobulinemia recognize the same determinants of evolution into symptomatic lymphoid disorders: proposal for a common prognostic scoring system.Q44492438
Clinical course of patients with relapsed multiple myelomaQ44544763
Single versus double autologous stem-cell transplantation for multiple myeloma.Q44706045
Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial.Q46006794
Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedureQ46094234
Pathogenesis of myeloma bone diseaseQ46224909
Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myelomaQ46291462
Bortezomib or high-dose dexamethasone for relapsed multiple myelomaQ46549268
Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial.Q46573449
Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology GroupQ46859424
Benefit of complete response in multiple myeloma limited to high-risk subgroup identified by gene expression profilingQ46868726
Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: final results of phase III US Intergroup Trial S9321.Q46907944
Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trialQ46985882
Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma.Q51401479
Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: results of the randomized phase III HOVON-65/ GMMG-HD4 trial.Q53127020
Prevalence of monoclonal gammopathy of undetermined significanceQ34506801
International uniform response criteria for multiple myeloma.Q34549410
Lenalidomide plus dexamethasone for relapsed multiple myeloma in North AmericaQ34585268
Elimination of the need for urine studies in the screening algorithm for monoclonal gammopathies by using serum immunofixation and free light chain assaysQ34590500
Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial.Q34604658
Bortezomib plus melphalan and prednisone for initial treatment of multiple myelomaQ34815786
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disordersQ34884527
Review of 1027 patients with newly diagnosed multiple myelomaQ35045634
Clinicopathological definition of Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's MacroglobulinemiaQ35116840
Management of multiple myeloma: a systematic review and critical appraisal of published studiesQ35121715
Approach to the treatment of multiple myeloma: a clash of philosophies.Q35230189
Pomalidomide plus low-dose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: comparison of 2 dosing strategies in dual-refractory diseaseQ35794132
Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myelomaQ35848146
A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myelomaQ35848744
Trisomies in multiple myeloma: impact on survival in patients with high-risk cytogeneticsQ35849219
Proteasome inhibition as a novel therapeutic target in human cancer.Q36014046
Improved survival in multiple myeloma and the impact of novel therapiesQ36478461
Monoclonal gammopathy of undetermined significance, Waldenström macroglobulinemia, AL amyloidosis, and related plasma cell disorders: diagnosis and treatmentQ36480921
Myeloma bone disease: pathogenetic mechanisms and clinical assessment.Q36501851
Incidence of monoclonal gammopathy of undetermined significance and estimation of duration before first clinical recognitionQ36523517
VTD combination therapy with bortezomib-thalidomide-dexamethasone is highly effective in advanced and refractory multiple myelomaQ36878944
The molecular characterization and clinical management of multiple myeloma in the post-genome era.Q36939043
Prevention of thalidomide- and lenalidomide-associated thrombosis in myelomaQ37038414
A monoclonal gammopathy precedes multiple myeloma in most patientsQ37209020
Treatment of myeloma: cure vs controlQ37284081
Is the International Staging System superior to the Durie-Salmon staging system? A comparison in multiple myeloma patients undergoing autologous transplantQ37303841
Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelinesQ37454445
Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myelomaQ37523265
International myeloma working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100).Q37530452
Mobilization in myeloma revisited: IMWG consensus perspectives on stem cell collection following initial therapy with thalidomide-, lenalidomide-, or bortezomib-containing regimensQ37533983
Patterns of monoclonal gammopathy of undetermined significance and multiple myeloma in various ethnic/racial groups: support for genetic factors in pathogenesisQ37545358
Acquisition of a multidrug-resistant phenotype with a proteasome inhibitor in multiple myelomaQ39839596
Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myelomaQ40201943
Incidence of extramedullary disease in patients with multiple myeloma in the era of novel therapy, and the activity of pomalidomide on extramedullary myelomaQ41891711
Diagnosis of smoldering multiple myelomaQ42617275
Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised pQ42781523
Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: a randomized controlled trialQ42861085
Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 phase III trial.Q42914716
P433issue3
P921main subjectmultiple myelomaQ467635
P304page(s)226-235
P577publication date2013-03-01
P1433published inAmerican Journal of HematologyQ4744246
P1476titleMultiple myeloma: 2013 update on diagnosis, risk-stratification, and management
P478volume88

Reverse relations

cites work (P2860)
Q38700339A gene expression signature distinguishes innate response and resistance to proteasome inhibitors in multiple myeloma
Q37709866A novel 3D mesenchymal stem cell model of the multiple myeloma bone marrow niche: biologic and clinical applications
Q28543087A novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclasts
Q37231523Abnormalities in Chromosomes 1q and 13 Independently Correlate With Factors of Poor Prognosis in Multiple Myeloma
Q38692424Age-related health care disparities in multiple myeloma.
Q48666333Autologous Stem Cell Transplantation in Multiple Myeloma in the Era of Novel Drug Induction: A Retrospective Single-Center Analysis
Q87733927Can genome array screening replace FISH as a front-line test in multiple myeloma?
Q91949934Challenges in the cultural adaptation of the German Myeloma Patient Outcome Scale (MyPOS): an outcome measure to support routine symptom assessment in myeloma care
Q35097105Chromosome 8q24.1/c-MYC abnormality: a marker for high-risk myeloma
Q34447010Clinical course and prognosis of non-secretory multiple myeloma
Q34455098Clinical course of light-chain smouldering multiple myeloma (idiopathic Bence Jones proteinuria): a retrospective cohort study
Q30369423Consolidation in multiple myeloma - current status and perspectives
Q36325334Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity
Q52638803Epidemiology of multiple myeloma in 17 Latin American countries: an update.
Q35631433Ex Vivo Maintenance of Primary Human Multiple Myeloma Cells through the Optimization of the Osteoblastic Niche
Q41031177Favorable long-term outcome of patients with multiple myeloma using a frontline tandem approach with autologous and non-myeloablative allogeneic transplantation
Q26745957First line vs delayed transplantation in myeloma: Certainties and controversies
Q41914138GSK3-mediated MAF phosphorylation in multiple myeloma as a potential therapeutic target
Q38115224IV. Initial treatment of multiple myeloma.
Q61813810Immunotherapy in myeloma: how far have we come?
Q37171994Impact of primary molecular cytogenetic abnormalities and risk of progression in smoldering multiple myeloma
Q33418300Improved response rates with bortezomib in relapsed or refractory multiple myeloma: an observational study in Chinese patients
Q26777803Interpretation of cytogenetic results in multiple myeloma for clinical practice
Q38190593Is it time for preemptive drug treatment of asymptomatic (smoldering) multiple myeloma?
Q37282307Lenalidomide maintenance for high-risk multiple myeloma after allogeneic hematopoietic cell transplantation.
Q53089985MYD88 mutant lymphoplasmacytic lymphoma/Waldenström macroglobulinemia has distinct clinical and pathological features as compared to its mutation negative counterpart.
Q35766816MicroC(3): an ex vivo microfluidic cis-coculture assay to test chemosensitivity and resistance of patient multiple myeloma cells
Q41591687Modifications of the mouse bone marrow microenvironment favor angiogenesis and correlate with disease progression from asymptomatic to symptomatic multiple myeloma
Q42086621Multiple Myeloma Mimics Bone Metastasis From a Rectal Adenocarcinoma
Q38951283Multiple myeloma: managing a complex blood cancer
Q36318271Non-secreting multiple myeloma switches to IgD of lamda type: a case report and review of literature
Q47198067Outcome and survival of myeloma patients diagnosed 2008-2015. Real world data on 4904 patients from the Swedish Myeloma Registry (SMR).
Q40827148Outcome of allogeneic transplantation in newly diagnosed and relapsed/refractory multiple myeloma: long-term follow-up in a single institution
Q36279610Outcomes Among High-Risk and Standard-Risk Multiple Myeloma Patients Treated With High-Dose Chemotherapy and Autologous Hematopoietic Stem-Cell Transplantation
Q39710073Pesticide exposures and the risk of multiple myeloma in men: An analysis of the North American Pooled Project
Q33415759Phase 1 study of weekly dosing with the investigational oral proteasome inhibitor ixazomib in relapsed/refractory multiple myeloma
Q88060350Predicting multiple myeloma disease activity by analyzing natural calcium isotopic composition
Q40691084Prognostic significance of increased bone marrow microcirculation in newly diagnosed multiple myeloma: results of a prospective DCE-MRI study
Q38756525RGS1 expression is associated with poor prognosis in multiple myeloma
Q37325843Responsiveness of cytogenetically discrete human myeloma cell lines to lenalidomide: lack of correlation with cereblon and interferon regulatory factor 4 expression levels
Q37524970Risk stratification, treatment selection, and transplant eligibility in multiple myeloma: a qualitative study of the perspectives and self-reported practices of oncologists
Q38808490Single-cell analysis of targeted transcriptome predicts drug sensitivity of single cells within human myeloma tumors.
Q36640775Small-lymphoid cells and myeloid antigen expression in a patient with IgG myeloma: A case report
Q36711842Targeting PYK2 mediates microenvironment-specific cell death in multiple myeloma
Q40813914The clinical impact of thalidomide maintenance after autologous stem cell transplantation in patients with newly diagnosed multiple myeloma in real clinical practice of Korea.
Q28075927The insulin-like growth factor system in multiple myeloma: diagnostic and therapeutic potential
Q35996498The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM
Q36081225The prognostic impact of inflammatory factors in patients with multiple myeloma treated with thalidomide in Korea
Q38211267The skinny on obesity and plasma cell myeloma: a review of the literature.
Q45728462Treatment options for myeloma
Q44559311Treatment with bortezomib-based regimens improves overall response and predicts for survival in patients with primary or secondary plasma cell leukemia: Analysis of the Greek myeloma study group
Q38255333Understanding biology to tackle the disease: Multiple myeloma from bench to bedside, and back
Q35751888Well plate-based perfusion culture device for tissue and tumor microenvironment replication
Q58023753Zielgerichtete Therapien bei hämatologischen Erkrankungen

Search more.