Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis

scientific article

Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

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P356DOI10.4049/JIMMUNOL.173.3.1596
P698PubMed publication ID15265887
P5875ResearchGate publication ID8443496

P2093author name stringAlirio J Melendez
Farazeela Bte Mohd Ibrahim
P2860cites workMolecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoformQ22253469
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Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agentsQ28215555
The chemotactic receptor for human C5a anaphylatoxinQ28280054
Tumor necrosis factor-  induces adhesion molecule expression through the sphingosine kinase pathwayQ29041393
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Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemiaQ33857573
Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established diseaseQ33940942
Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat.Q35028480
Differing patterns of P-selectin expression in lung injuryQ35753557
Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transductionQ36235805
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C5a stimulates secretion of tumor necrosis factor from human mononuclear cells in vitro. Comparison with secretion of interleukin 1 beta and interleukin 1 alphaQ36355106
Crosstalk between ARF6 and protein kinase Calpha in Fc(gamma)RI-mediated activation of phospholipase D1.Q38297576
Tumor necrosis factor receptor-mediated signaling pathwaysQ40669397
Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primatesQ40682681
The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signalingQ40751632
Molecular diversity of sphingolipid signallingQ40890961
Sphingolipid metabolites: members of a new class of lipid second messengersQ40950086
Differentiation-dependent switch in protein kinase C isoenzyme activation by FcgammaRI, the human high-affinity receptor for immunoglobulin G.Q40955846
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular traffickingQ41041395
A molecular switch changes the signalling pathway used by the Fc gamma RI antibody receptor to mobilise calciumQ41058534
Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptorQ41205257
Sphingosine kinase from Swiss 3T3 fibroblasts: a convenient assay for the measurement of intracellular levels of free sphingoid basesQ41419761
The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggeringQ42136631
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogensQ42805681
Protective effects of C5a blockade in sepsisQ44260666
Gene expression in mature neutrophils: early responses to inflammatory stimuliQ44666480
Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a.Q47263925
Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis.Q54140083
Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a.Q55067822
Recombinant C5a enhances interleukin 1 and tumor necrosis factor release by lipopolysaccharide-stimulated monocytes and macrophagesQ67655157
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectchemotaxisQ658145
P304page(s)1596-1603
P577publication date2004-08-01
P1433published inJournal of ImmunologyQ3521441
P1476titleAntisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis
P478volume173

Reverse relations

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