The phosphodiesterase-4 inhibitor rolipram attenuates heroin-seeking behavior induced by cues or heroin priming in rats

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The phosphodiesterase-4 inhibitor rolipram attenuates heroin-seeking behavior induced by cues or heroin priming in rats is …
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P356DOI10.1017/S1461145714000595
P698PubMed publication ID24832929

P2093author name stringWenhua Zhou
Dan Fu
Anna Sun
Huaqiang Zhu
Miaojun Lai
Weisheng Chen
Han-Ting Zhang
Dingding Zhuang
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Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in ratsQ48338110
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Phosphodiesterase 4 inhibitors, rolipram and diazepam block the adaptive changes observed during morphine withdrawal in the heartQ48586597
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Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behaviorQ28386419
The phosphodiesterase-4 (PDE4) inhibitor rolipram decreases ethanol seeking and consumption in alcohol-preferring Fawn-Hooded ratsQ28388227
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CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuliQ34038682
Muscarinic type 2 receptors in the lateral dorsal tegmental area modulate cocaine and food seeking behavior in ratsQ34116719
Vagus nerve stimulation inhibits heroin-seeking behavior induced by heroin priming or heroin-associated cues in ratsQ34167688
Regulation of gene expression and cocaine reward by CREB and ΔFosBQ34270890
Interaction between the antidepressant-like behavioral effects of beta adrenergic agonists and the cyclic AMP PDE inhibitor rolipram in ratsQ34433189
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Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampusQ37346336
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatmentQ37625928
A polyamine-deficient diet opposes hyperalgesia, tolerance and the increased anxiety-like behaviour associated with heroin withdrawal in ratsQ39239761
Molecular Mechanisms of Drug Reinforcement and AddictionQ40441120
Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cellsQ42025731
The Type IV phosphodiesterase inhibitor rolipram interferes with drug-induced conditioned place preference but not immediate early gene induction in miceQ42461221
Preliminary evidence for an involvement of the cholinergic system in the sedative effects of rolipram in ratsQ42610451
Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signalingQ42719378
A therapeutic strategy to prevent morphine dependence and tolerance by coadministration of cAMP-related reagents with morphine.Q43070596
Effects of rolipram and diazepam on the adaptive changes induced by morphine withdrawal in the hypothalamic paraventricular nucleus.Q43291343
Conditioned withdrawal drives heroin consumption and decreases reward sensitivity.Q44369585
P433issue9
P304page(s)1397-1407
P577publication date2014-05-15
P1433published inThe International Journal of NeuropsychopharmacologyQ7742309
P1476titleThe phosphodiesterase-4 inhibitor rolipram attenuates heroin-seeking behavior induced by cues or heroin priming in rats
P478volume17