The IKKε kinase in breast cancer: from oncogenesis to treatment resistance

scientific article

The IKKε kinase in breast cancer: from oncogenesis to treatment resistance is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1051/MEDSCI/2011276014
P9108Erudit article ID2011276014
P698PubMed publication ID21718646
P5875ResearchGate publication ID51457143

P50authorNathalie GrandvauxQ85655989
P2860cites workIKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinasesQ22010432
IKKepsilon is part of a novel PMA-inducible IkappaB kinase complexQ22254561
NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylationQ28141521
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayQ28190704
Triggering the interferon antiviral response through an IKK-related pathwayQ28191761
IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2Q28198356
IKKi/IKKϵ Plays a Key Role in Integrating Signals Induced by Pro-inflammatory StimuliQ28203011
Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunityQ28290992
Shared principles in NF-kappaB signalingQ29547234
Integrative genomic approaches identify IKBKE as a breast cancer oncogeneQ33287979
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformationQ33456429
IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancerQ33662031
Estrogen receptor mutations and changes in downstream gene expression and signalingQ34112728
Mouse mammary tumor virus c-rel transgenic mice develop mammary tumorsQ35169909
The NF-kappaB/IkappaB signaling system: a molecular target in breast cancer therapyQ36010801
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infectionQ36402648
Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infectionQ36402672
Advances in targeting IKK and IKK-related kinases for cancer therapyQ37036746
Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancerQ37257188
The IKK-related kinases: from innate immunity to oncogenesisQ37374645
Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancerQ37376029
CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processesQ37448141
Genomic structure and functional characterization of the promoter region of human IkappaB kinase-related kinase IKKi/IKKvarepsilon gene.Q38325357
Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.Q39628016
Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpointQ39826073
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activationQ39869345
Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilonQ40247827
IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylationQ40255884
Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancersQ42458122
Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cellsQ46853168
Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.Q46890324
[CYLD deubiquitinase as a recurrent target in oncogenic processes].Q53285080
[The alternative NF-kB activation pathway and cancer: friend or foe?].Q53426911
P433issue6-7
P407language of work or nameFrenchQ150
P304page(s)619-625
P577publication date2011-06-01
P1433published inmédecine/sciencesQ3332441
P1476titleThe IKKε kinase in breast cancer: from oncogenesis to treatment resistance
P478volume27

Reverse relations

cites work (P2860)
Q33717414Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.
Q35940908Diallyl disulfide inhibits TNFα induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling
Q53285080[CYLD deubiquitinase as a recurrent target in oncogenic processes].

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