Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27.

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Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1022411909
P356DOI10.1007/S00109-004-0579-3
P8608Fatcat IDrelease_4pcq5gn6pna6li5v5gi52dpf4m
P698PubMed publication ID15322702

P50authorDirk J van VeldhuisenQ82060328
Wiek H van GilstQ42159122
Frans BoomsmaQ45026209
P2093author name stringSaraswati Pokharel
Yigal M Pinto
Rudolf A de Boer
Albert J H Suurmeijer
Derk A van Kampen
Frans Boomsma
Markus Flesch
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Influence of age on neurohormonal activation and prognosis in patients with chronic heart failureQ77147303
"Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardiumQ77167575
Role of AT1 and AT2 receptors in regulation of MAPKs and MKP-1 by ANG II in adult cardiac myocytesQ77181476
Early captopril treatment inhibits DNA synthesis in endothelial cells and normalization of maximal coronary flow in infarcted rat heartsQ77755953
The Smad pathwayQ22253316
Measurement of protein using bicinchoninic acidQ26778491
Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitroQ28344062
Redox regulation of MAPK pathways and cardiac hypertrophy in adult rat cardiac myocyteQ32055216
Effect of N-acetyl-seryl-aspartyl-lysyl-proline on DNA and collagen synthesis in rat cardiac fibroblasts.Q32184250
Role of Ras and Mapks in TGFbeta signalingQ33857574
Signalling via stress-activated mitogen-activated protein kinases in the cardiovascular systemQ33870078
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic miceQ40388321
N-acetyl-Ser-Asp-Lys-Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts.Q40713598
Cross-talk between the p42/p44 MAP kinase and Smad pathways in transforming growth factor beta 1-induced furin gene transactivationQ40793124
Physiological characterization of the hypertensive transgenic rat TGR(mREN2)27.Q41078608
Regulation of angiotensin II-stimulated osteopontin expression in cardiac microvascular endothelial cells: role of p42/44 mitogen-activated protein kinase and reactive oxygen speciesQ42505155
Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunctionQ42509981
ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblastsQ42511347
Involvement of MAP kinase cascades in Smad7 transcriptional regulationQ42513106
Angiotensin II via activation of type 1 receptor upregulates expression of endoglin in human coronary artery endothelial cellsQ43801296
Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failureQ43803594
Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense.Q44108423
AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartanQ44883049
Differential role of MAP kinases in stimulation of hepatocyte growth by EGF and G-protein-coupled receptor agonistsQ45713470
Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in ratsQ46495069
Angiotensin II type 1 receptor-induced extracellular signal-regulated protein kinase activation is mediated by Ca2+/calmodulin-dependent transactivation of epidermal growth factor receptorQ47904445
Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart FailureQ57396530
Reduction in Left Ventricular Messenger RNA for Transforming Growth Factor β 1 Attenuates Left Ventricular Fibrosis and Improves Survival Without Lowering Blood Pressure in the Hypertensive TGR(mRen2)27 RatQ57570924
Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitroQ72415178
Stage-specific differential activation of mitogen-activated protein kinases in hypertrophied and failing rat heartsQ73683776
Angiotensin II activates collagen I gene through a mechanism involving the MAP/ER kinase pathwayQ74316935
Angiotensin II-induced cardiac hypertrophy is associated with different mitogen-activated protein kinase activation in normotensive and hypertensive miceQ74335673
P433issue10
P921main subjectheart failureQ181754
homozygosityQ114049690
P304page(s)678-687
P577publication date2004-08-20
P1433published inJournal of Molecular MedicineQ6295593
P1476titleExtracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27.
P478volume82

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