Selective targeting of point-mutated KRAS through artificial microRNAs

scientific article published on 8 May 2017

Selective targeting of point-mutated KRAS through artificial microRNAs is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1073/PNAS.1620562114
P932PMC publication ID5448175
P698PubMed publication ID28484014

P50authorCarlo Maria CroceQ640381
Matteo FassanQ39364695
Vincenzo CoppolaQ40648671
P2093author name stringAlessandro Laganà
Giulia Romano
Paolo Fadda
Nicola Zanesi
Lara Rizzotto
Mario Acunzo
Raleigh Kladney
Luigi Fattore
Dario Veneziano
Giovanni Nigita
P2860cites workPrinciples of microRNA-target recognitionQ21146368
The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulationQ21562295
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinibQ21563446
Human MicroRNA targetsQ21563637
Somatic activation of the K-ras oncogene causes early onset lung cancer in miceQ40809826
Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarityQ41626666
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Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation.Q42564735
The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.Q54535188
RAS oncogenes: the first 30 years.Q55036584
Cancer genome landscapesQ22242276
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancerQ24604601
MicroRNA targeting specificity in mammals: determinants beyond seed pairingQ24607724
MicroRNAs: target recognition and regulatory functionsQ24609584
Detecting microRNA binding and siRNA off-target effects from expression dataQ24658272
siRNA Versus miRNA as Therapeutics for Gene SilencingQ26786876
KRAS as a Therapeutic TargetQ27007866
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsQ27860926
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Targeting RAS signalling pathways in cancer therapyQ28201363
Causes and consequences of microRNA dysregulation in cancerQ28258994
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimeticsQ28469345
Specificity of microRNA target selection in translational repressionQ28776123
The role of site accessibility in microRNA target recognitionQ29547436
A comprehensive survey of Ras mutations in cancerQ30416821
miR-Synth: a computational resource for the design of multi-site multi-target synthetic miRNAsQ33635585
Development of siRNA payloads to target KRAS-mutant cancerQ34287993
3' UTR seed matches, but not overall identity, are associated with RNAi off-targetsQ34496075
Drugging the undruggable RAS: Mission possible?Q35163434
Oncogenic Ras and its role in tumor cell invasion and metastasisQ35690261
Mapping the human miRNA interactome by CLASH reveals frequent noncanonical bindingQ36833119
The genetics and biology of KRAS in lung cancerQ37354111
Isoform-specific ras functions in development and cancerQ37401355
Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapyQ38037048
MicroRNA and cancer--a brief overviewQ38258057
Targeting RAS-ERK signalling in cancer: promises and challengesQ38272894
K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.Q38584436
Therapeutic strategies for targeting ras proteinsQ39262217
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancersQ39430432
Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells.Q40400258
P4510describes a project that usesImageJQ1659584
limmaQ112236343
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
P304page(s)E4203-E4212
P577publication date2017-05-08
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleSelective targeting of point-mutated KRAS through artificial microRNAs
P478volume114

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cites work (P2860)
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