Predicting Pulmonary Pharmacokinetics from In Vitro Properties of Dry Powder Inhalers.

scientific article published on 10 August 2017

Predicting Pulmonary Pharmacokinetics from In Vitro Properties of Dry Powder Inhalers. is …
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scholarly articleQ13442814

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P356DOI10.1007/S11095-017-2235-Y
P8608Fatcat IDrelease_ldffqnadu5bqxczuxeeqz5g42q
P698PubMed publication ID28799097

P50authorGuenther HochhausQ55427575
P2093author name stringMong-Jen Chen
Renishkumar Delvadia
Bhawana Saluja
Mohammad Absar
Xiangyin Wei
Sharvari Bhagwat
Uta Schilling
P2860cites workVenous thromboembolism and lung cancer: a reviewQ26784184
Pharmacokinetics and systemic activity of fluticasone via Diskus and pMDI, and of budesonide via TurbuhalerQ28365894
A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification SystemQ29042157
Modeling and comparison of dissolution profilesQ34215811
Dry powder inhalers and the right things to remember: a concept reviewQ35426748
Pharmacokinetics and systemic effects of inhaled fluticasone propionate in chronic obstructive pulmonary disease.Q35825280
Equivalent lung deposition of budesonide in vivo: a comparison of dry powder inhalers using a pharmacokinetic methodQ35826707
Effects of ramp-up of inspired airflow on in vitro aerosol dose delivery performance for certain dry powder inhalersQ35896882
Solubility Enhancement of Budesonide and Statistical Optimization of Coating Variables for Targeted Drug DeliveryQ36112246
In Vitro Tests for Aerosol Deposition. IV: Simulating Variations in Human Breath Profiles for Realistic DPI TestingQ37365183
Advances in inhaled technologies: understanding the therapeutic challenge, predicting clinical performance, and designing the optimal inhaled productQ38185862
Inhaled corticosteroids: potency, dose equivalence and therapeutic indexQ38390724
Predicting Exposure After Oral Inhalation of the Selective Glucocorticoid Receptor Modulator, AZD5423, Based on Dose, Deposition Pattern, and Mechanistic Modeling of Pulmonary DispositionQ39291826
Systems Pharmacology Approach for Prediction of Pulmonary and Systemic Pharmacokinetics and Receptor Occupancy of Inhaled DrugsQ40258577
A pharmacokinetic simulation tool for inhaled corticosteroids.Q42507245
Fluticasone furoate, a novel inhaled corticosteroid, demonstrates prolonged lung absorption kinetics in man compared with inhaled fluticasone propionateQ42678294
Single-dose and steady-state pharmacokinetic and pharmacodynamic evaluation of therapeutically clinically equivalent doses of inhaled fluticasone propionate and budesonide, given as Diskus or Turbohaler dry-powder inhalers to healthy subjectsQ43836979
Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway.Q44926315
In vitro tests for aerosol deposition. I: Scaling a physical model of the upper airways to predict drug deposition variation in normal humansQ44970565
Fluticasone propionate plasma concentration and systemic effect: effect of delivery device and duration of administrationQ46700775
Fast calculation of van der Waals volume as a sum of atomic and bond contributions and its application to drug compoundsQ47632144
Normal organ weights in men: part II-the brain, lungs, liver, spleen, and kidneysQ48766796
An evaluation of the systemic bioavailability of mometasone furoate (MF) after oral inhalation from a MF/formoterol fumarate metered-dose inhaler versus an MF dry-powder inhaler in healthy subjectsQ50247636
Dissolution testing of powders for inhalation: influence of particle deposition and modeling of dissolution profiles.Q51083967
Evaluation of the Transwell System for Characterization of Dissolution Behavior of Inhalation Drugs: Effects of Membrane and Surfactant.Q51620315
Models of human lung airways and their application to inhaled particle deposition.Q52767790
New Method for Calculating the Intrinsic Absorption Rate of DrugsQ53021749
Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilutionQ68861405
Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered-dose inhaler P-MDIQ72426713
Bioavailability and metabolism of mometasone furoate following administration by metered-dose and dry-powder inhalers in healthy human volunteersQ73181965
Absorption kinetics after inhalation of fluticasone propionate via the Diskhaler, Diskus and metered-dose inhaler in healthy volunteersQ73350559
Pharmacokinetic/pharmacodynamic aspects of aerosol therapy using glucocorticoids as a modelQ74321636
Dissolution rates of finely divided drug powders. II. Micronized methyl-prednisoloneQ79523075
Validation of a general in vitro approach for prediction of total lung deposition in healthy adults for pharmaceutical inhalation productsQ86165264
P433issue12
P921main subjectpharmacokineticsQ323936
P304page(s)2541-2556
P577publication date2017-08-10
P1433published inPharmaceutical ResearchQ7180737
P1476titlePredicting Pulmonary Pharmacokinetics from In Vitro Properties of Dry Powder Inhalers
P478volume34