Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism

scientific article published in December 2004

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BCP.2004.08.013
P698PubMed publication ID15498516
P5875ResearchGate publication ID8217663

P50authorChris de GraafQ50029895
P2093author name stringJan N M Commandeur
Nico P E Vermeulen
Peter H J Keizers
Barbara M A Lussenburg
Letty M Mentink
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)2263-2271
P577publication date2004-12-01
P1433published inBiochemical PharmacologyQ864229
P1476titleInfluence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism
P478volume68

Reverse relations

cites work (P2860)
Q33224153Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy
Q88763523CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712
Q24298673Crystal structure of human cytochrome P450 2D6
Q35008695Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1.
Q42594109Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations
Q34295888Functional characterization of a first avian cytochrome P450 of the CYP2D subfamily (CYP2D49)
Q56992052Metabolism ofN-substituted 7-methoxy-4-(aminomethyl) -coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction points
Q34994964New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme
Q37611786Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.
Q36376115Roles of phenylalanine at position 120 and glutamic acid at position 222 in the oxidation of chiral substrates by cytochrome P450 2D6.
Q43892219Using a homology model of cytochrome P450 2D6 to predict substrate site of metabolism
Q46703082Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

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