A new hypothesis of neurodegenerative diseases: the deleterious network hypothesis

scientific article published in October 1996

A new hypothesis of neurodegenerative diseases: the deleterious network hypothesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0306-9877(96)90071-7
P698PubMed publication ID8910880

P2093author name stringYing W
P2860cites workDefective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosisQ24306886
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisQ28131805
Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosisQ28335672
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutationQ29547561
Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal gangliaQ33322579
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosisQ34300016
Excitatory amino acids as a final common pathway for neurologic disorders.Q34321926
Replication of the neurochemical characteristics of Huntington's disease by quinolinic acidQ34384772
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?Q35254212
The oxidant stress hypothesis in Parkinson's disease: evidence supporting itQ35626743
Calcium as sculptor and destroyer of neural circuitryQ35680713
IgG from amyotrophic lateral sclerosis patients increases current through P-type calcium channels in mammalian cerebellar Purkinje cells and in isolated channel protein in lipid bilayerQ36724305
Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body diseaseQ36760254
Oxygen radicals and neuropsychiatric illness. Some speculationsQ37152812
What excitotoxin kills striatal neurons in Huntington's disease? Clues from neurochemical studiesQ37578887
Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?Q37936915
Bioenergetic and oxidative stress in neurodegenerative diseasesQ40369216
Age-related changes in cerebral oxidative metabolism. Implications for drug therapy.Q40450162
Aging, energy, and oxidative stress in neurodegenerative diseases.Q40478731
Amyotrophic lateral sclerosis is a multifactorial diseaseQ40546531
Ion transport systems and Ca2+ regulation in aging neurons.Q40586893
Amyotrophic lateral sclerosis: recent insights from genetics and transgenic miceQ40612435
Magnesium and Calcium Contents in CNS Tissues of Amyotrophic Lateral Sclerosis Patients from the Kii Peninsula, JapanQ41083434
Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonistsQ41154685
The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosisQ41413618
Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxinQ41458956
Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of GuamQ41624368
Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patientsQ41652065
Midbrain dopaminergic cell loss in Parkinson's disease and MPTP-induced parkinsonism: sparing of calbindin-D28k-containing cellsQ41843416
Striatal deficiency of L-pyroglutamic acid in Huntington's disease is accompanied by increased plasma levelsQ42204389
Striatal calcium channel antagonist receptors in Huntington's disease and Parkinson's diseaseQ42506358
Deleterious network hypothesis of Alzheimer's diseaseQ44245798
Focal reductions of cerebral blood flow in amyotrophic lateral sclerosis: a [99mTc]-d,l-HMPAO SPECT studyQ44254770
Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's diseaseQ44480462
Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescenceQ44498466
Muscle lactate dehydrogenase activity is decreased in murine motor neuron diseaseQ44580826
Intranigral iron injection induces behavioral and biochemical "parkinsonism" in ratsQ44848373
Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage.Q44934024
Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterizationQ45291026
Excitotoxicity of L-dopa and 6-OH-dopa: implications for Parkinson's and Huntington's diseasesQ45293874
The mechanism of glutamate-induced degeneration of cultured Huntington's disease and control fibroblastsQ45296572
Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicityQ46070812
Point mutations of mitochondrial genome in Parkinson's diseaseQ48075275
An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's diseaseQ48184003
NMDA-dependent superoxide production and neurotoxicityQ48234286
Parkinson's disease and basal ganglia calcifications: prevalence and clinico-radiological correlationsQ52046704
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondriaQ54965159
Brainstem motoneuron pools that are selectively resistant in amyotrophic lateral sclerosis are preferentially enriched in parvalbumin: Evidence from monkey brainstem for a calcium-mediated mechanism in sporadic ALSQ57540072
Oxidative damage to protein in sporadic motor neuron disease spinal cordQ59544371
Iron, selenium and glutathione peroxidase activity are elevated in sporadic motor neuron diseaseQ59544375
Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's diseaseQ71694543
A role for amplified protein kinase C activity in the pathogenesis of amyotrophic lateral sclerosisQ71894900
Toward an understanding of the role of glutamate in experimental parkinsonism: Agonist‐sensitive sites in the basal gangliaQ72100592
Decrease in Cu/Zn- and Mn-superoxide dismutase activities in brain and spinal cord of patients with amyotrophic lateral sclerosisQ72116629
Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptorsQ72209261
Parkinson's disease: a test of the multifactorial etiologic hypothesisQ72391740
Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosisQ72529952
Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosisQ72621641
Cu/Zn superoxide dismutase activity in familial and sporadic amyotrophic lateral sclerosisQ72663413
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study GroupQ72759362
P433issue4
P921main subjectneurodegenerationQ1755122
deleterious network hypothesisQ108305420
P304page(s)307-313
P577publication date1996-10-01
P1433published inMedical HypothesesQ5558534
P1476titleA new hypothesis of neurodegenerative diseases: the deleterious network hypothesis.
P478volume47

Reverse relations

cites work (P2860)
Q44179098Chemotherapeutically induced deletion of expanded triplet repeats
Q73168807Deleterious network hypothesis of aging
Q74817365Deleterious network hypothesis of apoptosis
Q63341579Evaluation of free radical production, mitochondrial membrane potential and cytoplasmic calcium in mammalian neurons by flow cytometry
Q83728053Huntington's Disease
Q38151200Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms
Q89880514Multimodal Abnormalities of Brain Structure and Function in Major Depressive Disorder: A Meta-Analysis of Neuroimaging Studies
Q37015565NAD+ and NADH in neuronal death
Q36090617Oxidative stress and NAD+ in ischemic brain injury: current advances and future perspectives
Q23920334Potential occupational risks for neurodegenerative diseases
Q35120158Serum containing Tongqiaohuoxue decoction suppresses glutamate-induced PC12 cell injury
Q44924668Toxic effect of chloromycetin on the ultrastructures of the motor neurons of the Chinese tree shrew (Tupaia belangeri).

Search more.