The NLRP3 inflammasome

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-844456)

The NLRP3 inflammasome is …
instance of (P31):
biological pathwayQ4915012

External links are
P2888exact matchhttps://identifiers.org/reactome:R-HSA-844456
P3937Reactome IDR-HSA-844456

P2860cites workThe inflammasomesQ24304087
The NLRP3 inflammasome: a sensor of immune danger signalsQ37379011
P703found in taxonHomo sapiensQ15978631
P527has part(s)ATP binds to P2X7Q50291962
P2X7 forms oligomeric non-selective cation channelsQ50291963
P2X7 mediates loss of intracellular K+Q50291964
P2X7 mediates membrane pores that include pannexin-1Q50291965
SGT1 binds HSP90Q50291966
SGT1:HSP90 binds inactive NLRP3Q50291967
TXNIP binds reduced thioredoxinQ50291968
ROS oxidize thioredoxinQ50291970
TXNIP is released from oxidized thioredoxinQ50291971
TXNIP binds NLRP3Q50291972
NLRP3 activation by small moleculesQ50291977
NLRP3 activation by elicitor proteinsQ50291979
NLRP3 oligomerizes via NACHT domainsQ50291980
NLRP3 recruits PYCARD (ASC) via a PYD-PYD interactionQ50291982
PYCARD recruits procaspase-1 via CARDQ50291983
PSTPIP1 binds PyrinQ50291985
Pyrin binds ASCQ50291987
Expression of NLRP3 geneQ56858965
P361part ofInflammasomesQ45317048

Reverse relations

part of (P361)
Q50291962ATP binds to P2X7
Q56858965Expression of NLRP3 gene
Q50291979NLRP3 activation by elicitor proteins
Q50291977NLRP3 activation by small molecules
Q50291980NLRP3 oligomerizes via NACHT domains
Q50291982NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction
Q50291963P2X7 forms oligomeric non-selective cation channels
Q50291964P2X7 mediates loss of intracellular K+
Q50291965P2X7 mediates membrane pores that include pannexin-1
Q50291985PSTPIP1 binds Pyrin
Q50291983PYCARD recruits procaspase-1 via CARD
Q50291987Pyrin binds ASC
Q50291970ROS oxidize thioredoxin
Q50291966SGT1 binds HSP90
Q50291967SGT1:HSP90 binds inactive NLRP3
Q50291972TXNIP binds NLRP3
Q50291968TXNIP binds reduced thioredoxin
Q50291971TXNIP is released from oxidized thioredoxin

Q45317048Inflammasomeshas part(s)P527

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