PCP/CE pathway

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-4086400)

PCP/CE pathway is …
instance of (P31):
biological pathwayQ4915012
Wnt signaling pathway, planar cell polarity pathwayQ14897651

External links are
P2888exact matchhttps://identifiers.org/reactome:R-HSA-4086400
P3937Reactome IDR-HSA-4086400

P2860cites workWnt5a functions in planar cell polarity regulation in miceQ28505898
Ryks: new partners for Wnts in the developing and regenerating nervous systemQ29347289
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulationQ29619296
Ror receptor tyrosine kinases: orphans no moreQ34850710
Planar cell polarity in DrosophilaQ35624641
Wnt signaling pathways meet Rho GTPases.Q37388913
Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis.Q37443849
Wnt regulation of planar cell polarity (PCP).Q38058908
Wnt5 is required for tail formation in the zebrafish embryo.Q45345873
P703found in taxonHomo sapiensQ15978631
P527has part(s)DAAM1 recruits PFN1Q50298817
RYK binds WNT5A and VANGL2Q50298818
WNT5A binds ROR2 and VANGL2Q50298819
VANGL2 is phosphorylated in response to WNT5AQ50298820
Asymmetric localization of PCP proteinsQ45318262
WNT5A-dependent internalization of FZD4Q45318264
WNT5A-dependent internalization of FZD2, FZD5 and ROR2Q45318265
WNTs bind the FZD receptor to initiate PCP pathwayQ50298811
DVL is recruited to the receptorQ50298812
WNT-dependent phosphorylation of DVLQ50298813
ppDVL binds DAAM1Q50298814
DAAM1 recruits GTP-bound RHOAQ50298815
ppDVL recruits RACQ50298816
P361part ofBeta-catenin independent WNT signalingQ45318259

Reverse relations

part of (P361)
Q45318262Asymmetric localization of PCP proteins
Q50298815DAAM1 recruits GTP-bound RHOA
Q50298817DAAM1 recruits PFN1
Q50298812DVL is recruited to the receptor
Q50298818RYK binds WNT5A and VANGL2
Q50298820VANGL2 is phosphorylated in response to WNT5A
Q50298813WNT-dependent phosphorylation of DVL
Q50298819WNT5A binds ROR2 and VANGL2
Q45318265WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Q45318264WNT5A-dependent internalization of FZD4
Q50298811WNTs bind the FZD receptor to initiate PCP pathway
Q50298814ppDVL binds DAAM1
Q50298816ppDVL recruits RAC

Q45318259Beta-catenin independent WNT signalinghas part(s)P527

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