Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors

scientific article published on 22 July 2013

Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/JNC.12353
P698PubMed publication ID23796581
P5875ResearchGate publication ID241696670

P50authorPietro FarinelliQ47296725
François Paquet-DurandQ43075401
P2093author name stringFlorian Lang
Eberhart Zrenner
Ioana Alesutan
Blanca Arango-Gonzalez
Jakob Völkl
Per A R Ekström
P2860cites workAge-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.Q43239627
Mouse retina explants after long-term culture in serum free mediumQ43806291
Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouseQ45090790
Cell differentiation in the retina of the mouseQ45193462
Differential Akt activation in the photoreceptors of normal and rd1 miceQ46402991
FGF19 exhibits neuroprotective effects on adult mammalian photoreceptors in vitroQ46667349
Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant miceQ46699750
Calpain is activated in degenerating photoreceptors in the rd1 mouseQ46888728
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membraneQ47627574
Homozygous tandem duplication within the gene encoding the beta-subunit of rod phosphodiesterase as a cause for autosomal recessive retinitis pigmentosa.Q48076634
Expression of Klotho protein in the inner ear.Q48496365
Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cellsQ48925490
Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.Q52163868
Klotho suppresses RIG-I-mediated senescence-associated inflammation.Q54611511
Oxidative stress decreases klotho expression in a mouse kidney cell line.Q54657313
Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposureQ56985745
Excessive Activation of Poly(ADP-Ribose) Polymerase Contributes to Inherited Photoreceptor Degeneration in the Retinal Degeneration 1 MouseQ59209075
Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho proteinQ24309454
Mutation of the mouse klotho gene leads to a syndrome resembling ageingQ24328782
Suppression of aging in mice by the hormone KlothoQ24650916
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF familyQ24676527
Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retinaQ28240665
Mutations in the human retinal degeneration slow gene in autosomal dominant retinitis pigmentosaQ28252073
alpha-Klotho as a regulator of calcium homeostasisQ28306317
In vivo klotho gene transfer ameliorates angiotensin II-induced renal damageQ28574231
Fibroblast growth factor (FGF) soluble receptor 1 acts as a natural inhibitor of FGF2 neurotrophic activity during retinal degenerationQ28575584
Regulation of fibroblast growth factor-23 signaling by klothoQ28587100
Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant ratsQ33963936
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.Q34197301
Pathways to photoreceptor cell death in inherited retinal degenerationsQ34312941
Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse.Q34545446
Co-receptor requirements for fibroblast growth factor-19 signalingQ34665759
Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosaQ34951881
Amelioration of progressive renal injury by genetic manipulation of Klotho geneQ35844644
Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitisQ36266724
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17Q36288869
Role of peripherin/rds in vertebrate photoreceptor architecture and inherited retinal degenerationsQ36650544
Regulation of oxidative stress by the anti-aging hormone klothoQ36835699
FGFR3 and FGFR4 do not mediate renal effects of FGF23.Q36985772
Current understanding of klothoQ37087785
Photoreceptor cell death mechanisms in inherited retinal degeneration.Q37316717
Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70.Q39800972
Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanismsQ41370456
Klotho is a substrate for alpha-, beta- and gamma-secretaseQ42078322
Nuclear localization of Klotho in brain: an anti-aging proteinQ42541748
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectphotoreceptor proteinQ7187894
retinitis pigmentosaQ847057
P304page(s)868-879
P577publication date2013-07-22
P1433published inJournal of NeurochemistryQ6295643
P1476titleRetinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors
P478volume127

Reverse relations

cites work (P2860)
Q35667633Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats
Q37261449Klotho regulates retinal pigment epithelial functions and protects against oxidative stress
Q47364210Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration
Q41374149Possible role of sialylation of retinal protein glycans in the regulation of electroretinogram response in mice
Q37230437The age-regulating protein klotho is vital to sustain retinal function
Q38730521The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection