Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice

scientific article published on 6 December 2011

Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.24675
P698PubMed publication ID21932402
P5875ResearchGate publication ID51656411

P2093author name stringJian Zhang
Liang Tang
Wei Dong
Wen Yang
Yan Lin
Chao Wang
Meng-Chao Wu
Zhong Li
Hong-Yang Wang
Liang Hu
Tao Luo
Qiong Liu
Yu-Qiong Li
Hui-Lu Zhang
Fu-Quan Wu
He-Xin Yan
Le-Xing Yu
Shan-Shan Zou
Long-Yi Zheng
Ya-Qin He
P2860cites workGender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 productionQ29614596
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint controlQ29616465
EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell featuresQ30493364
Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesisQ33344462
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis.Q33929406
The origin and liver repopulating capacity of murine oval cellsQ34582398
Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?Q34988085
Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signalingQ36497297
WNT/beta-catenin signaling in liver health and diseaseQ36804161
Liver cancer stem cellsQ36835025
Deregulated direct targets of the hepatitis B virus (HBV) protein, HBx, identified through chromatin immunoprecipitation and expression microarray profilingQ37372165
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesisQ37621008
Hepatitis B virus X protein stimulates IL-6 expression in hepatocytes via a MyD88-dependent pathwayQ39645695
Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.Q39656536
Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cellsQ39976254
High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B.Q39997004
Identification and characterization of tumorigenic liver cancer stem/progenitor cellsQ40119609
CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicityQ40186273
Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat.Q40869986
Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinomaQ41548933
Oval cell numbers in human chronic liver diseases are directly related to disease severity.Q42050840
Intermediate hepatobiliary cells predict an increased risk of hepatocarcinogenesis in patients with hepatitis C virus-related cirrhosis.Q44410161
Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells.Q44706836
2-acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: confocal and electron microscopic studiesQ44880267
Direct effects of interleukin-6 on liver progenitor oval cells in cultureQ45156962
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.Q46615053
Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells.Q46913797
Wnt/beta-catenin signaling mediates oval cell response in rodentsQ46955919
Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liverQ47835382
A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cellsQ50115050
Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.Q52580893
HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice.Q53370903
Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver.Q53449416
Cancer stem cellsQ80312237
Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitisQ82294435
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectHepatitis B virusQ6844
P304page(s)108-120
P577publication date2011-12-06
P1433published inHepatologyQ15724398
P1476titleHepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice
P478volume55

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cites work (P2860)
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