TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

scientific article published in December 2013

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CMET.2013.11.002
P698PubMed publication ID24315369
P5875ResearchGate publication ID259245729

P50authorChristian HölscherQ37831053
Olavo Bohrer AmaralQ42404085
Jean C HouzelQ56073526
Mychael V LourencoQ57057252
José B CarvalheiraQ59450289
Lício VellosoQ64745748
Paula Campello-CostaQ74182006
Letícia Forny-GermanoQ80863708
Sérgio Teixeira FerreiraQ86818733
Fernanda De FeliceQ87769550
Julia R ClarkeQ92209886
William L. KleinQ104975865
Jordano Brito-MoreiraQ106909123
Theresa R BomfimQ106909148
André F BatistaQ106909159
Rudimar L FrozzaQ106909168
P2093author name stringDouglas P Munoz
Luciana B Sathler
Aristobolo M Silva
Sheila Espírito-Santo
Cesar A Silva
Léo Freitas-Correa
P433issue6
P921main subjectAlzheimer's diseaseQ11081
TNFQ18032037
P304page(s)831-843
P577publication date2013-12-01
P1433published inCell MetabolismQ1254684
P1476titleTNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys
P478volume18

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cites work (P2860)
Q55001725A New Venue of TNF Targeting.
Q91973479A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease
Q37087410A Systems View of the Differences between APOE ε4 Carriers and Non-carriers in Alzheimer's Disease
Q35006687Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies
Q97423162Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms
Q64285109Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway
Q93006380Adipose Tissue and Brain Metabolic Responses to Western Diet-Is There a Similarity between the Two?
Q37724402Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station
Q48262702Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.
Q35084406Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.
Q61959960Amelioration of Aluminum Maltolate-Induced Inflammation and Endoplasmic Reticulum Stress-Mediated Apoptosis by Tannoid Principles of Emblica officinalis in Neuronal Cellular Model
Q35327172Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis
Q28384947Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease
Q48259811Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons
Q55560479Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights.
Q64074885Astrocyte Heterogeneity: Impact to Brain Aging and Disease
Q46352159Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model.
Q90745617Behavioral Abnormalities in Knockout and Humanized Tau Mice
Q89767521Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
Q57022699Bone protection by inhibition of microRNA-182
Q38253639Brain alterations and clinical symptoms of dementia in diabetes: aβ/tau-dependent and independent mechanisms
Q38515312Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease
Q48396253Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.
Q26739374CX3CL1/CX3CR1 in Alzheimer's Disease: A Target for Neuroprotection
Q47928995Calcium Dysregulation in Alzheimer's Disease: A Target for New Drug Development
Q50199042Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
Q39445809Clinical and therapeutic potential of protein kinase PKR in cancer and metabolism
Q48152519Consequences of gestational diabetes to the brain and behavior of the offspring
Q39141602Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice.
Q26765530Current Research Therapeutic Strategies for Alzheimer's Disease Treatment
Q39023028Cytokines and Cytokine Receptors Involved in the Pathogenesis of Alzheimer's Disease
Q92209534Decreased Quality of Life in Individuals with Type 2 Diabetes Mellitus Is Associated with Emotional Distress
Q54111592Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models.
Q50206017Dissecting Endoplasmic Reticulum Unfolded Protein Response (UPRER) in Managing Clandestine Modus Operandi of Alzheimer's Disease
Q38195215Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
Q98177367Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions
Q89265602ER Proteostasis Control of Neuronal Physiology and Synaptic Function
Q59128157Elevated Glutamate and Glutamine Levels in the Cerebrospinal Fluid of Patients With Probable Alzheimer's Disease and Depression
Q33730922Endoplasmic reticulum stress and inflammation in the central nervous system
Q30841556Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy
Q92237102Epac1 inhibits PKR to reduce NLRP3 inflammasome proteins in retinal endothelial cells
Q91636820Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APP/PS1 Mice
Q90929504Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models
Q52142981Fibrillar Amyloid-β Accumulation Triggers an Inflammatory Mechanism Leading to Hyperphosphorylation of the Carboxyl-Terminal End of Tau Polypeptide in the Hippocampal Formation of the 3×Tg-AD Transgenic Mouse.
Q39393398Fine-tuning PERK signaling for neuroprotection.
Q38606226Hippocampal insulin resistance and cognitive dysfunction
Q40278876IRE1 signaling exacerbates Alzheimer's disease pathogenesis
Q38247021IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity
Q27003841Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease
Q26773657Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease
Q64262753Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes
Q59808617Insulin Resistance in Alzheimer's Disease
Q64092659Insulin Signaling Impairment in the Brain as a Risk Factor in Alzheimer's Disease
Q89542342Insulin resistance and impaired lipid metabolism as a potential link between diabetes and Alzheimer's disease
Q48252699Integrated Stress Response: Connecting ApoE4 to Memory Impairment in Alzheimer's Disease.
Q48268984Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice
Q28394967Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors
Q48481506Intranasal Insulin Administration Ameliorates Streptozotocin (ICV)-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Memory Impairment in Rats
Q92964508Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease
Q38938961Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal
Q38561865Linking insulin with Alzheimer's disease: emergence as type III diabetes
Q41899669Memory loss in Alzheimer's disease: are the alterations in the UPR network involved in the cognitive impairment?
Q47140950Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization
Q38974881Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer's disease pathology
Q92649463Multi-Loop Model of Alzheimer Disease: An Integrated Perspective on the Wnt/GSK3β, α-Synuclein, and Type 3 Diabetes Hypotheses
Q60046048N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model
Q90228110Natural Products as Modulators of the Proteostasis Machinery: Implications in Neurodegenerative Diseases
Q90236862Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases
Q47120381Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.
Q26866194New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases
Q90305669Novel roles of ER stress in repressing neural activity and seizures through Mdm2- and p53-dependent protein translation
Q47641854PKR Inhibition Rescues Memory Deficit and ATF4 Overexpression in ApoE ε4 Human Replacement Mice
Q43143483PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model
Q42371247PKR involvement in Alzheimer's disease
Q54978322PKR modulates abnormal brain signaling in experimental obesity.
Q61449861PKR: A Kinase to Remember
Q38903340Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity
Q37614594Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?
Q47845996Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides
Q38682450Regulation of Posttranslational Modifications of HMGB1 During Immune Responses
Q28081526Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory
Q92703384Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD
Q38934950Shared Genetic Etiology between Type 2 Diabetes and Alzheimer's Disease Identified by Bioinformatics Analysis
Q26784170Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer's Disease: Impacts on Cognitive Decline
Q59795046Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity
Q35643397Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease
Q48524916Stimulation of TLR4 Attenuates Alzheimer's Disease-Related Symptoms and Pathology in Tau-Transgenic Mice
Q28077671Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students
Q54977832The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade.
Q39410246The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic Significance
Q39182975The Multi-Target Drug M30 Shows Pro-Cognitive and Anti-Inflammatory Effects in a Rat Model of Alzheimer's Disease
Q61448813The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer's Disease
Q26751165The association between PGC-1α and Alzheimer's disease
Q50050282The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.
Q33600053The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease
Q39021127The neuronal insulin receptor in its environment
Q41828232The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease
Q38823805Therapeutic Potential of Antidiabetic Medications in the Treatment of Cognitive Dysfunction and Dementia
Q48338374Training Microglia to Resist Alzheimer's Disease
Q36487154Translational control in synaptic plasticity and cognitive dysfunction
Q38928927Treatment strategies in Alzheimer's disease: a review with focus on selenium supplementation
Q33704278Tumor necrosis factor α Inhibition for Alzheimer's Disease
Q34475073d-serine levels in Alzheimer's disease: implications for novel biomarker development
Q37369248eIF2α phosphorylation controls thermal nociception

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