| scholarly article | Q13442814 |
| P356 | DOI | 10.1124/DMD.111.040923 |
| P953 | full work available online at | https://syndication.highwire.org/content/doi/10.1124/dmd.111.040923 |
| P698 | PubMed publication ID | 22048522 |
| P5875 | ResearchGate publication ID | 51765517 |
| P2093 | author name string | Shigeru Ohta | |
| Chise Tateno | |||
| Yaichiro Kotake | |||
| Kazumi Sugihara | |||
| Shigeyuki Kitamura | |||
| Seigo Sanoh | |||
| Toru Horie | |||
| Yoshitaka Tayama | |||
| Aya Horiguchi | |||
| Hiroki Ohshita | |||
| P2860 | cites work | Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance | Q31007513 |
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| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 322-328 | |
| P577 | publication date | 2011-11-02 | |
| P1433 | published in | Drug Metabolism and Disposition | Q1261140 |
| P1476 | title | Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver | |
| Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver | |||
| P478 | volume | 40 |
| Q38131587 | A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next? |
| Q28077505 | Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury |
| Q38097076 | Aldehyde oxidase and its importance in novel drug discovery: present and future challenges |
| Q46422523 | Aldehyde oxidase-dependent species difference in hepatic metabolism of fasudil to hydroxyfasudil |
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| Q34340443 | Can ‘humanized’ mice improve drug development in the 21st century? |
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| Q48125728 | Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen |
| Q41703687 | Extensive double humanization of both liver and hematopoiesis in FRGN mice. |
| Q46478338 | Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods |
| Q35031282 | Making Models Work: Library Annotation through Phenoclustering. |
| Q38802917 | Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro-In Vivo Comparisons |
| Q46536471 | Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes |
| Q41317951 | Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver |
| Q86730577 | Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes |
| Q38066611 | Strategies for a comprehensive understanding of metabolism by aldehyde oxidase |
| Q38404573 | The application of engineered liver tissues for novel drug discovery |
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