An enzymatic domain for the formation of cyclic ethers in complex polyketides

scientific article published in December 2013

An enzymatic domain for the formation of cyclic ethers in complex polyketides is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/ANIE.201307406
P698PubMed publication ID24307486

P2093author name stringBrandon I Morinaka
Jörn Piel
Petra Pöplau
Sarah Frank
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Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blockedQ46746349
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A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetlesQ24540336
Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthaseQ27663985
Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesisQ27677831
A type I/type III polyketide synthase hybrid biosynthetic pathway for the structurally unique ansa compound kendomycinQ33381277
Biosynthesis of ethers: unusual or common natural events?Q33533794
A late-stage intermediate in salinomycin biosynthesis is revealed by specific mutation in the biosynthetic gene cluster.Q34072847
Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritinaQ34574375
Convergent strategies for the total synthesis of polycyclic ether marine metabolitesQ34767955
Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211.Q35739218
Exploring the chemistry of uncultivated bacterial symbionts: antitumor polyketides of the pederin familyQ36078571
The stereochemistry of ketoreductionQ36293766
Biosynthesis of polyketides by trans-AT polyketide synthasesQ37750498
SmI(2)-induced reductive cyclizations for the synthesis of cyclic ethers and applications in natural product synthesisQ37760821
Differential efficacy of toxic pederin in deterring potential arthropod predators of Paederus (Coleoptera: Staphylinidae) offspringQ38900775
Bacterial biosynthetic gene clusters encoding the anti-cancer haterumalide class of molecules: biogenesis of the broad spectrum antifungal and anti-oomycete compound, oocydin A.Q41308837
A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycinQ42600168
Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closureQ42603932
Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137.Q42624264
Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A.Q43098572
Analysis of the sorangicin gene cluster reinforces the utility of a combined phylogenetic/retrobiosynthetic analysis for deciphering natural product assembly by trans-AT PKS.Q43466165
Molecular identification of an endosymbiotic bacterium associated with pederin biosynthesis in Paederus sabaeus (Coleoptera: Staphylinidae).Q43911051
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclizationQ44563363
Intermediates released from a polyether-producing polyketide synthase provide insight into the mechanism of oxidative cyclizationQ44603745
P433issue50
P407language of work or nameEnglishQ1860
P304page(s)13215-13218
P577publication date2013-12-01
P1433published inAngewandte Chemie International EditionQ62023953
P1476titleAn enzymatic domain for the formation of cyclic ethers in complex polyketides
P478volume52

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cites work (P2860)
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