Missense mutations in exon 2 of the MED12 gene are involved in IGF-2 overexpression in uterine leiomyoma.

scientific article published on 11 July 2014

Missense mutations in exon 2 of the MED12 gene are involved in IGF-2 overexpression in uterine leiomyoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/MOLEHR/GAU055
P698PubMed publication ID25015674
P5875ResearchGate publication ID263860752

P50authorAndrea TinelliQ42335546
Antonio MalvasiQ42870251
Serafina MassariQ57005905
P2093author name stringS Di Tommaso
P2860cites workA standard curve based method for relative real time PCR data processingQ24811524
CDK8 is a stimulus-specific positive coregulator of p53 target genesQ28235350
The human Mediator complex: a versatile, genome-wide regulator of transcriptionQ28276700
Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signalingQ28592138
Fibroids display an anti-angiogenic gene expression profile when compared with adjacent myometriumQ33967595
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomasQ34210977
Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomasQ34789573
Function and regulation of the Mediator complexQ34904976
Activation domain–mediator interactions promote transcription preinitiation complex assembly on promoter DNAQ36347875
Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancerQ36731136
Myoma pseudocapsule: a distinct endocrino-anatomical entity in gynecological surgeryQ37519449
Therapeutic drugs in the treatment of symptomatic uterine fibroidsQ38126545
IGF2 and cancerQ38147784
Comparison of chromosome aberrations in leiomyoma and leiomyosarcoma using FISH on archival tissuesQ38483545
Laparoscopic myomectomy focusing on the myoma pseudocapsule: technical and outcome reportsQ39255950
PTEN modulates insulin-like growth factor II (IGF-II)-mediated signaling; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cellsQ40639993
The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator functionQ42082510
Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assemblyQ42493019
Insulin-like growth factor II in uterine smooth-muscle tumors: maintenance of genomic imprinting in leiomyomata and loss of imprinting in leiomyosarcomata.Q45953446
Molecular characterization of uterine fibroids and its implication for underlying mechanisms of pathogenesisQ46047671
Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumorsQ47855828
Characterization of uterine leiomyomas by whole-genome sequencing.Q50935563
Ultrasound evaluation of uterine healing after laparoscopic intracapsular myomectomy: an observational study.Q50936671
Use of X-chromosome inactivation pattern to determine the clonal origins of uterine leiomyoma and leiomyosarcoma.Q52007771
Gene expression analysis reveals an angiogenic profile in uterine leiomyoma pseudocapsuleQ53102062
Expression of insulin-like growth factors (IGFs) and IGF signaling: molecular complexity in uterine leiomyomas.Q54535265
Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology.Q54761196
Distinctive proliferative phase differences in gene expression in human myometrium and leiomyomata.Q54761203
P433issue10
P921main subjectoverexpressionQ61643320
P304page(s)1009-1015
P577publication date2014-07-11
P1433published inMolecular Human ReproductionQ15761794
P1476titleMissense mutations in exon 2 of the MED12 gene are involved in IGF-2 overexpression in uterine leiomyoma
P478volume20

Reverse relations

cites work (P2860)
Q50050533Analysis of MED12 Mutation in Multiple Uterine Leiomyomas in South Korean patients
Q60954837Expanded Somatic Mutation Spectrum of MED12 Gene in Uterine Leiomyomas of Saudi Arabian Women
Q35928937MED12 exon 2 mutations in phyllodes tumors of the breast
Q26800203Mediator kinase module and human tumorigenesis
Q50785220Paracrine Pathways in Uterine Leiomyoma Stem Cells Involve Insulinlike Growth Factor 2 and Insulin Receptor A.
Q53057851Pathogenesis, Classification, Histopathology, and Symptomatology of Fibroids
Q40977787Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma
Q50993068The study of MED12 gene mutations in uterine leiomyomas from Iranian patients.
Q90103124Understanding Obesity as a Risk Factor for Uterine Tumors Using Drosophila
Q53057860Uterine-Preserving Operative Therapy of Uterus Myomatosus
Q36935561Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells

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