IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients

scientific article published on 7 December 2016

IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/2162402X.2016.1261242
P8608Fatcat IDrelease_uk2tjrxjzrh6bjnkzi36hf3wyu
P932PMC publication ID5353942
P698PubMed publication ID28344869

P50authorPaolo Antonio AsciertoQ89457677
Rolf KiesslingQ92024154
Ester SimeoneQ110644240
Maria WolodarskiQ114522841
Rossana TallericoQ114523316
Cinzia GarofaloQ114523318
Elio GullettaQ114523319
Mariaelena CaponeQ30505575
Sofia JohanssonQ38319849
Andrea AnichiniQ38324345
Gennaro CilibertoQ38800176
Francesco ColucciQ42608618
Yago Pico de CoañaQ56882779
Antonio M GrimaldiQ57071231
Domenico MallardoQ57649479
Ennio CarboneQ58804014
Gabriele MadonnaQ62676303
Elina StaafQ63677582
Costanza M CristianiQ63677588
Valentina CarannanteQ63677589
Rosa SottileQ63677591
P2093author name stringKlas Kärre
Paolo Frumento
Eleonora Palella
P2860cites workPrognostic significance of natural killer cell activity in patients with gastric carcinoma: a multivariate analysisQ73572644
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanomaQ24629841
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activationQ24675931
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulationQ24678846
Immune Checkpoint Blockade in Cancer TherapyQ26830509
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
Enhancement of antitumor immunity by CTLA-4 blockadeQ28275730
CTLA-4 control over Foxp3+ regulatory T cell functionQ29619413
Nivolumab and ipilimumab versus ipilimumab in untreated melanomaQ29620657
Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancerQ33418729
Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockadeQ33714165
„Natural” killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cellQ33906475
Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexesQ34411539
Enrichment of CD56(dim)KIR + CD57 + highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patientsQ35114206
Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunityQ35208414
Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patientsQ35616397
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiotaQ35833921
Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9Q35876978
Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicityQ35909663
Biomarkers on melanoma patient T cells associated with ipilimumab treatmentQ36480617
The role of regulatory T cells in the control of natural killer cells: relevance during tumor progressionQ36652214
NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.Q37170785
Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patientsQ37430286
Therapeutic applications: natural killer cells in the clinic.Q38169644
Interleukin-15 in the treatment of cancerQ38264072
Investigation of serum proteome alterations in human endometriosis.Q38469802
Immunologic correlates in the course of treatment with immunomodulating antibodiesQ38475103
Anchorage independency promoted tumor malignancy of melanoma cells under reattachment through elevated interleukin-8 and CXC chemokine receptor 1 expressionQ38937617
Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanomaQ38944336
The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-α productionQ39157852
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumorsQ39546314
Baseline Biomarkers for Outcome of Melanoma Patients Treated with PembrolizumabQ40506025
Increases in Absolute Lymphocytes and Circulating CD4+ and CD8+ T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with IpilimumabQ40758666
Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with IpilimumabQ40964128
Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.Q42186944
Reversal of natural killer cell exhaustion by TIM-3 blockadeQ43180026
Biomarkers for immunostimulatory monoclonal antibodies in combination strategies for melanoma and other tumor typesQ46537519
Ipilimumab increases activated T cells and enhances humoral immunity in patients with advanced melanoma.Q50980327
Increased serum levels of interleukin-15 correlate with negative prognostic factors in extranodal NK/T cell lymphoma.Q54310181
Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy.Q54432520
„Natural”︁ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotypeQ54628850
Orthogonal projections to latent structures (O-PLS)Q56435041
Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivoQ56898738
Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanomaQ57781473
P433issue2
P304page(s)e1261242
P577publication date2016-12-07
P1433published inOncoImmunologyQ18026500
P1476titleIL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients
P478volume6

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cites work (P2860)
Q49884881An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells.
Q64881806Biomarkers for Immune Checkpoint Inhibitor-Mediated Tumor Response and Adverse Events.
Q92265378Biomarkers, measured during therapy, for response of melanoma patients to immune checkpoint inhibitors: a systematic review
Q64095697Circulating CD56 NK cells inversely correlate with survival of melanoma patients
Q93012736Circulating biomarkers predictive of tumor response to cancer immunotherapy
Q92854312Genetic and Epigenetic Biomarkers of Immune Checkpoint Blockade Response
Q101120982Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
Q89965774NK Cell-Based Immune Checkpoint Inhibition
Q41661175Natural Killer Cells: Angels and Devils for Immunotherapy
Q99558031PD-1 checkpoint blockade in advanced melanoma patients: NK cells, monocytic subsets and host PD-L1 expression as predictive biomarker candidates
Q90636970Rebalancing Immune Homeostasis to Treat Autoimmune Diseases
Q92845900Regulation of murine NK cell exhaustion through the activation of the DNA damage repair pathway
Q89796270Soluble Tim3 detection by time-resolved fluorescence immunoassay and its application in membranous nephropathy
Q56889003Targeting Checkpoint Receptors and Molecules for Therapeutic Modulation of Natural Killer Cells
Q90176787Unleashing Natural Killer Cells in the Tumor Microenvironment-The Next Generation of Immunotherapy?

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