Understanding the essential proton-pumping kinetic gates and decoupling mutations in cytochrome c oxidase

scientific article published on 23 May 2017

Understanding the essential proton-pumping kinetic gates and decoupling mutations in cytochrome c oxidase is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2017PNAS..114.5924L
P356DOI10.1073/PNAS.1703654114
P932PMC publication ID5468613
P698PubMed publication ID28536198

P50authorMårten WikströmQ6241658
Gregory A. VothQ57509235
P2093author name stringJessica M J Swanson
Ruibin Liang
P2860cites workProton-coupled electron transfer in cytochrome oxidase.Q37807395
The role of the K-channel and the active-site tyrosine in the catalytic mechanism of cytochrome c oxidaseQ38742670
A mutation in subunit I of cytochrome oxidase from Rhodobacter sphaeroides results in an increase in steady-state activity but completely eliminates proton pumpingQ44205127
A mechanistic principle for proton pumping by cytochrome c oxidaseQ46691933
The curious case of the hydrated proton.Q51538352
Role of subunit III and its lipids in the molecular mechanism of cytochrome c oxidase.Q51638333
Functional hydration and conformational gating of proton uptake in cytochrome c oxidase.Q51795116
Mutations in the D-channel of cytochrome c oxidase causes leakage of the proton pump.Q54373300
Tracing the D-pathway in reconstituted site-directed mutants of cytochrome c oxidase from Paracoccus denitrificansQ73861792
Heme/Copper Terminal OxidasesQ77646446
Mutations which decouple the proton pump of the cytochrome c oxidase from Rhodobacter sphaeroides perturb the environment of glutamate 286Q80063010
Energy diagrams and mechanism for proton pumping in cytochrome c oxidaseQ80782220
Molecular basis of proton uptake in single and double mutants of cytochrome c oxidaseQ84197485
Proton uptake and pKa changes in the uncoupled Asn139Cys variant of cytochrome c oxidaseQ85887269
A D-pathway mutation decouples the Paracoccus denitrificans cytochrome c oxidase by altering the side-chain orientation of a distant conserved glutamateQ27652552
All-atom empirical potential for molecular modeling and dynamics studies of proteinsQ27860468
Proton-coupled electron transfer drives the proton pump of cytochrome c oxidaseQ28306078
Proton pump coupled to cytochrome c oxidase in mitochondriaQ28646276
The Origin of Coupled Chloride and Proton Transport in a Cl(-)/H(+) AntiporterQ28821139
Multiscale simulations reveal key features of the proton-pumping mechanism in cytochrome c oxidaseQ28830505
Update of the CHARMM all-atom additive force field for lipids: validation on six lipid typesQ29616710
Exploring the proton pump mechanism of cytochrome c oxidase in real timeQ33273199
Exploration of the cytochrome c oxidase pathway puzzle and examination of the origin of elusive mutational effectsQ33350451
Partial steps of charge translocation in the nonpumping N139L mutant of Rhodobacter sphaeroides cytochrome c oxidase with a blocked D-channelQ33822922
Multiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza A M2 proton channelQ33853921
Decoupling mutations in the D-channel of the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides suggest that a continuous hydrogen-bonded chain of waters is essential for proton pumpingQ33875968
Computationally Efficient Multiconfigurational Reactive Molecular DynamicsQ33998210
The role of the D- and K-pathways of proton transfer in the function of the haem-copper oxidases.Q34044508
Escaping free-energy minimaQ34151010
The timing of proton migration in membrane-reconstituted cytochrome c oxidaseQ34298624
Intricate Role of Water in Proton Transport through Cytochrome c OxidaseQ34422851
Redox-coupled proton translocation in biological systems: proton shuttling in cytochrome c oxidaseQ34789063
Alternative initial proton acceptors for the D pathway of Rhodobacter sphaeroides cytochrome c oxidaseQ34858215
Impaired proton pumping in cytochrome c oxidase upon structural alteration of the D pathwayQ35022843
Glu-286 rotation and water wire reorientation are unlikely the gating elements for proton pumping in cytochrome C oxidaseQ35079430
Multiscale reactive molecular dynamicsQ36203108
The roles of the two proton input channels in cytochrome c oxidase from Rhodobacter sphaeroides probed by the effects of site-directed mutations on time-resolved electrogenic intraprotein proton transferQ36550302
Computationally Efficient Multiscale Reactive Molecular Dynamics to Describe Amino Acid Deprotonation in ProteinsQ36569958
Glutamic acid 242 is a valve in the proton pump of cytochrome c oxidase.Q36609135
Multiscale Simulations Reveal Key Aspects of the Proton Transport Mechanism in the ClC-ec1 AntiporterQ36753772
Proton solvation and transport in aqueous and biomolecular systems: insights from computer simulationsQ36789334
Proton uptake controls electron transfer in cytochrome c oxidaseQ36794410
Replacing Asn207 by aspartate at the neck of the D channel in the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides results in decoupling the proton pumpQ36873397
Role of aspartate 132 at the orifice of a proton pathway in cytochrome c oxidaseQ36895569
Mechanism and energetics of proton translocation by the respiratory heme-copper oxidasesQ36906260
Acid activation mechanism of the influenza A M2 proton channel.Q37417885
Variable proton-pumping stoichiometry in structural variants of cytochrome c oxidaseQ37698699
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)5924-5929
P577publication date2017-05-23
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleUnderstanding the essential proton-pumping kinetic gates and decoupling mutations in cytochrome c oxidase
P478volume114

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cites work (P2860)
Q91974256Cryo-EM structure of Neurospora crassa respiratory complex IV
Q57496244Dewetting transitions coupled to K-channel activation in cytochrome oxidase
Q50051643Hydrogen-Bonded Network and Water Dynamics in the D-channel of Cytochrome c Oxidase.
Q47407220Insights into functions of the H channel of cytochrome c oxidase from atomistic molecular dynamics simulations.
Q47652815Oxygen Activation and Energy Conservation by Cytochrome c Oxidase.
Q60303186Prediction of perturbed proton transfer networks
Q58101818Synthetic Fe/Cu Complexes: Toward Understanding Heme-Copper Oxidase Structure and Function

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