Plasmid DNA production for pharmaceutical use: role of specific growth rate and impact on process design

scientific article published on 24 May 2011

Plasmid DNA production for pharmaceutical use: role of specific growth rate and impact on process design is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/BIT.23138
P698PubMed publication ID21437880

P2093author name stringA Ross
K Bohle
P2860cites workGeneric plasmid DNA production platform incorporating low metabolic burden seed-stock and fed-batch fermentation processes.Q30376672
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Replication of the prophage P1 during the cell cycle of Escherichia coliQ40775086
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Characterization of the metabolic burden on Escherichia coli DH1 cells imposed by the presence of a plasmid containing a gene therapy sequenceQ45143240
High-yield production of pBR322-derived plasmids intended for human gene therapy by employing a temperature-controllable point mutationQ45879752
Cellular plasmid content and cloned-gene expression: some useful equationsQ46864471
Kinetic study of instability of recombinant plasmid pPLc23trpAl in E. coli using two-stage continuous culture systemQ46907453
Effects of recombinant plasmid content on growth properties and cloned gene product formation in Escherichia coliQ46961399
DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice.Q47831384
Plasmid-encoded protein: the principal factor in the "metabolic burden" associated with recombinant bacteriaQ47869692
A kinetic model for product formation in unstable recombinant populationsQ47871754
Requirements for rapid plasmid ColE1 copy number adjustments: a mathematical model of inhibition modes and RNA turnover rates.Q52243526
Investigation of subpopulation heterogeneity and plasmid stability in recombinant escherichia coli via a simple segregated model.Q52394849
Quantitative Model of ColE1 Plasmid Copy Number ControlQ52400715
ColE1 plasmid replication: a simple kinetic description from a structured model.Q52510929
On the kinetics of plasmid replication.Q53849202
Studies of host-plasmid interactions in recombinant microorganisms.Q54786508
Role of the Rom Protein in Copy Number Control of Plasmid pBR322 at Different Growth Rates inEscherichia coliK-12Q57695264
P433issue9
P921main subjectDNA designQ55213961
P304page(s)2099-2106
P577publication date2011-05-24
P1433published inBiotechnology and BioengineeringQ4915339
P1476titlePlasmid DNA production for pharmaceutical use: role of specific growth rate and impact on process design
P478volume108

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cites work (P2860)
Q58576673Optimization of fermentation conditions for an strain engineered using the response surface method to produce a novel therapeutic DNA vaccine for rheumatoid arthritis
Q51797850Physiological effects of pH gradients on Escherichia coli during plasmid DNA production.
Q45871951Plasmid DNA primary recovery from E. coli lysates by depth bed microfiltration.
Q40425661Plasmid pVAX1-NH36 purification by membrane and bead perfusion chromatography
Q41628326Segregated growth kinetics of Escherichia coli DH5α-NH36 in exponential-fed perfusion culture for pDNA vaccine production

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