Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain

scientific article published in January 2001

Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1006/MTHE.2000.0224
P698PubMed publication ID11162309
P5875ResearchGate publication ID12168122

P50authorMaria G. CastroQ38359288
P2093author name stringLowenstein PR
Thomas CE
Birkett D
Anozie I
P433issue1
P921main subjectAdenoviridaeQ193447
cytotoxicityQ246181
P304page(s)36-46
P577publication date2001-01-01
P1433published inMolecular TherapyQ15762400
P1476titleAcute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain
P478volume3

Reverse relations

cites work (P2860)
Q90283465A method for gene knockdown in the retina using a lipid-based carrier
Q37406976AAV for pain: steps towards clinical translation
Q44477381Adenoviral gene vector tethering to nanoparticle surfaces results in receptor-independent cell entry and increased transgene expression
Q42910583Adenoviral-mediated Cre expression effectively suppresses GlyT1 binding in the thalamic area of GlyT1 conditional knock-out mice
Q36172992Adenoviral-mediated gene transfer into the canine brain in vivo
Q39682986Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types
Q42613158Adenovirus expression of IL-1 and NF-kappaB inhibitors does not inhibit acute adenoviral-induced brain inflammation, but delays immune system-mediated elimination of transgene expression.
Q45856841Baculoviruses exhibit restricted cell type specificity in rat brain: a comparison of baculovirus- and adenovirus-mediated intracerebral gene transfer in vivo
Q92086199Bioengineering hemophilia A-specific microvascular grafts for delivery of full-length factor VIII into the bloodstream
Q38287249Central nervous system delivery of helper-dependent canine adenovirus corrects neuropathology and behavior in mucopolysaccharidosis type VII mice.
Q34193457Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain
Q39524681Combining glial cell line-derived neurotrophic factor gene delivery (AdGDNF) with L-arginine decreases contusion size but not behavioral deficits after traumatic brain injury
Q44204771Conditional expression of the tumor suppressor p16 in a heterotopic glioblastoma model results in loss of pRB expression
Q35095713Current and future strategies for the treatment of malignant brain tumors.
Q33641230Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging
Q35225590Delivery of full-length factor VIII using a piggyBac transposon vector to correct a mouse model of hemophilia A.
Q44204170Effects of combining electrical stimulation with BDNF gene transfer on the regeneration of crushed rat sciatic nerve
Q36658314Efficacy of nonviral gene transfer in the canine brain
Q40548342Efficient delivery and stable gene expression in a hematopoietic cell line using a chimeric serotype 35 fiber pseudotyped helper-dependent adenoviral vector
Q45877559Enhanced adenovirus transduction of hMSCs using 3D hydrogel cell carriers.
Q36464407Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system
Q33364523Evaluation of toxicity from high-dose systemic administration of recombinant adenovirus vector in vector-naive and pre-immunized mice.
Q47318878Evolutionary basis of a new gene- and immune-therapeutic approach for the treatment of malignant brain tumors: from mice to clinical trials for glioma patients
Q40378943Ex vivo nonviral gene delivery of μ-opioid receptor to attenuate cancer-induced pain
Q34069598Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology
Q36994063Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits.
Q45122755Functional applications of novel Semliki Forest virus vectors are limited by vector toxicity in cultures of primary neurons in vitro and in the substantia nigra in vivo
Q36367568Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms.
Q33917592Gene delivery with viral vectors for cerebrovascular diseases
Q37994717Gene therapy approaches for lysosomal storage disorders, a good model for the treatment of mendelian diseases
Q35045240Gene therapy for cerebral vascular disease: update 2003.
Q35074544Gene therapy for pituitary tumors: from preclinical models to clinical implementation
Q35340196Gene therapy for the nervous system: challenges and new strategies
Q43157946Gene transfer into neural cells in vitro using adenoviral vectors
Q33904294Gene transfer into rat brain using adenoviral vectors.
Q34375860Genetic engineering within the adult brain: implications for molecular approaches to behavioral neuroscience
Q28277560Gutless adenovirus: last-generation adenovirus for gene therapy
Q44420163HSV-1 VP22 augments adenoviral gene transfer to CNS neurons in the retina and striatum in vivo
Q40883683Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo
Q64376671Hes1 negatively regulates neurogenesis in the adult mouse dentate gyrus following traumatic brain injury
Q45884040High-capacity, helper-dependent, "gutless" adenoviral vectors for gene transfer into brain
Q45858691Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area.
Q36045396Immune problems in central nervous system cell therapy.
Q42861412Immune regulation of transgene expression in the brain: B cells regulate an early phase of elimination of transgene expression from adenoviral vectors
Q36498773Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions
Q36274402Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells.
Q36498768Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapses
Q34658351Impact of E1 and Cre on adenovirus vector amplification: developing MDCK CAV-2-E1 and E1-Cre transcomplementing cell lines.
Q33216908In vivo transgene expression from an adenoviral vector is altered following a 6-OHDA lesion of the dopamine system.
Q35131222Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences
Q34546483Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.
Q40483395Lentiviral-mediated delivery of Bcl-2 or GDNF protects against excitotoxicity in the rat hippocampus
Q45875626Magnetic nanoparticles enhance adenovirus transduction in vitro and in vivo
Q40485805Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences.
Q35131213Molecular basis of the inflammatory response to adenovirus vectors
Q37998570Molecular neurosurgery: vectors and vector delivery strategies
Q34135050Molecular therapy in a model neuroendocrine disease: developing clinical gene therapy for pituitary tumours.
Q34074765Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease.
Q40630598Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury
Q52549450Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord.
Q33985663Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders
Q36411432Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma
Q36498762One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.
Q35870480Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro
Q92678385Optimization of an ex vivo gene transfer to the hamstrings tendons muscle remnants: potential for genetic enhancement of bone healing
Q42442484Optimization of transgene expression at the posttranscriptional level in neural cells: implications for gene therapy
Q40557969Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain
Q34365087Preexisting immunity to adenovirus in rhesus monkeys fails to prevent vector-induced toxicity
Q44426809Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery
Q35120176Progress and problems with the use of viral vectors for gene therapy
Q35069550Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.
Q42022920Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 108 international units, but not lower doses, of adenoviral vectors into the brain
Q33985688Recent advances in the pharmacology of neurological gene therapy
Q38085469Recent gene therapy advancements for neurological diseases.
Q36569912Regulatable gene expression systems for gene therapy
Q36157542Regulatable gene expression systems for gene therapy applications: progress and future challenges
Q34233124Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.
Q37403279Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity
Q52552384Restoration of an impaired TGF-beta1 autocrine growth-inhibitory circuit results in growth inhibition of ovarian epithelial cancer cells and complete inhibition of their tumorigenicity.
Q36534329Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial
Q40413612Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses
Q35999648Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation.
Q41189810The Long and Winding Road: From the High-Affinity Choline Uptake Site to Clinical Trials for Malignant Brain Tumors
Q97646315Transient Chimeric Ad5/37 Fiber Enhances NK-92 Carrier Cell-Mediated Delivery of Oncolytic Adenovirus Type 5 to Tumor Cells
Q37946113Viral vectors for gene delivery to the central nervous system
Q36960666Viral vectors for in vivo gene transfer in Parkinson's disease: properties and clinical grade production.
Q33894621Viral vectors for neurotrophic factor delivery: a gene therapy approach for neurodegenerative diseases of the CNS
Q44576921Widespread distribution of beta-hexosaminidase activity in the brain of a Sandhoff mouse model after coinjection of adenoviral vector and mannitol.
Q38461882pUNISHER: a high-level expression cassette for use with recombinant viral vectors for rapid and long term in vivo neuronal expression in the CNS.

Search more.