New therapeutic targets in transfusion-dependent and -independent thalassemia.

scientific article published in December 2017

New therapeutic targets in transfusion-dependent and -independent thalassemia. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1182/ASHEDUCATION-2017.1.278
P932PMC publication ID6142569
P698PubMed publication ID29222267

P50authorMaria Domenica CappelliniQ56678936
Irene MottaQ64171712
P2860cites workThalassaemiaQ39708856
Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemiaQ40915310
Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducersQ40953481
Plerixafor and G-CSF combination mobilizes hematopoietic stem and progenitors cells with a distinct transcriptional profile and a reduced in vivo homing capacity compared to plerixafor alone.Q42361922
Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemiaQ42361973
Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesisQ42456197
Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the OPTIMAL CARE study.Q43208938
Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal womenQ44911435
Transplantation in thalassemia: Revisiting the Pesaro risk factors 25 years later.Q45941460
Transferrin therapy ameliorates disease in beta-thalassemic mice.Q50586962
Membrane-bound iron contributes to oxidative damage of beta-thalassaemia intermedia erythrocytesQ73416479
Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cellsQ89047120
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobinQ24293797
The inherited diseases of hemoglobin are an emerging global health burdenQ27686848
β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapiesQ28086960
Janus kinase-2 inhibitor fedratinib in patients with myelofibrosis previously treated with ruxolitinib (JAKARTA-2): a single-arm, open-label, non-randomised, phase 2, multicentre studyQ33442629
Reactivation of developmentally silenced globin genes by forced chromatin looping.Q34052021
Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias.Q34205528
Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportinQ35828757
miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F InductionQ36757075
Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in miceQ36897141
Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia veraQ37097115
Functional footprinting of regulatory DNA.Q37738675
Clinical experience with fetal hemoglobin induction therapy in patients with β-thalassemia.Q38073700
HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancersQ38592271
The mutual control of iron and erythropoiesis.Q38830409
Advances in understanding the mechanisms of erythropoiesis in homeostasis and disease.Q38904398
2017 Clinical trials update in new treatments of β-thalassemiaQ38922283
Transplantation for thalassemia major: alternative donorsQ38930821
Therapeutic potential of hepcidin - the master regulator of iron metabolismQ39014779
Gene Therapy for β-HemoglobinopathiesQ39220089
Investigational drugs in phase I and phase II clinical trials for thalassemia.Q39328286
P433issue1
P304page(s)278-283
P577publication date2017-12-01
P1433published inHematology / the Education Program of the American Society of HematologyQ26842068
P1476titleNew therapeutic targets in transfusion-dependent and -independent thalassemia
P478volume2017

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cites work (P2860)
Q99402725A comprehensive update of ICET-A Network on COVID-19 in thalassemias: what we know and where we stand
Q92424160Amustaline-glutathione pathogen-reduced red blood cell concentrates for transfusion-dependent thalassaemia
Q58580509Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess
Q64982592Thyroid Disorders in Homozygous β-Thalassemia: Current Knowledge, Emerging Issues and Open Problems.
Q60949866Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model

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