Trans-membrane peptide therapy for malignant glioma by use of a peptide derived from the MDM2 binding site of p53.

scientific article

Trans-membrane peptide therapy for malignant glioma by use of a peptide derived from the MDM2 binding site of p53. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1002413894
P356DOI10.1007/S11060-012-0860-1
P698PubMed publication ID22528789

P2093author name stringSachiko Yamada
Hiroshi Kanno
Nobutaka Kawahara
P2860cites workPeptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cellsQ23918117
The role of alpha-helical structure in p53 peptides as a determinant for their mechanism of cell death: necrosis versus apoptosisQ23919945
Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding siteQ23922326
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal ApoptosisQ28570309
Cellular uptake of the tat protein from human immunodeficiency virusQ29620627
Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein deliveryQ31577177
Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group studyQ33398291
Protection against ischemic brain injury by protein therapeuticsQ34431022
Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator proteinQ34556566
Protein Therapy: in vivo protein transduction by polyarginine (11R) PTD and subcellular targeting deliveryQ35100895
The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transportersQ37278005
Antennapedia homeobox peptide regulates neural morphogenesisQ37419251
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradationQ39540070
Ubiquitination-resistant p53 protein transduction therapy facilitates anti-cancer effect on the growth of human malignant glioma cellsQ40401963
Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.Q41063629
Intercellular trafficking and protein delivery by a herpesvirus structural proteinQ41133058
Analysis of the p53 gene and its expression in human glioblastoma cellsQ41488834
Screening the p53 status of human cell lines using a yeast functional assayQ42815910
A high-efficiency protein transduction system demonstrating the role of PKA in long-lasting long-term potentiation.Q43697222
Translocation of branched-chain arginine peptides through cell membranes: flexibility in the spatial disposition of positive charges in membrane-permeable peptidesQ44031394
Efficient growth inhibition of human osteosarcoma cells using a peptide derived from the MDM-2-binding site of p53.Q45855758
Gene therapy -- promises, problems and prospectsQ45883584
Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammationQ46454374
Selective inhibition of oncogenic ras-p21 in vivo by agents that block its interaction with jun-N-kinase (JNK) and jun proteins. Implications for the design of selective chemotherapeutic agents.Q48966114
p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53.Q52534736
Development of p53 protein transduction therapy using membrane-permeable peptides and the application to oral cancer cellsQ64378245
Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cellsQ73212113
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domainQ73400021
Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migrationQ77658726
P433issue1
P304page(s)7-14
P577publication date2012-04-18
P1433published inJournal of Neuro-OncologyQ15752119
P1476titleTrans-membrane peptide therapy for malignant glioma by use of a peptide derived from the MDM2 binding site of p53.
P478volume109

Reverse relations

cites work (P2860)
Q53088541A recombinant trans-membrane protein hMnSOD-R9 inhibits the proliferation of cervical cancer cells in vitro.
Q47844364Glioma targeting peptide in combination with the P53 C terminus inhibits glioma cell proliferation in vitro
Q38796979Inhibition of cell proliferation, migration and invasion by a glioma-targeted fusion protein combining the p53 C terminus and MDM2-binding domain
Q48229575Mustard-inspired delivery shuttle for enhanced blood-brain barrier penetration and effective drug delivery in glioma therapy.
Q33702044Protein therapy using MafA fused to a polyarginine transduction domain attenuates glucose levels of streptozotocin‑induced diabetic mice.
Q36544248Targeting MCM2 function as a novel strategy for the treatment of highly malignant breast tumors

Search more.