Development of a transgenic mouse model with immune tolerance for human coagulation factor VIIa

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Development of a transgenic mouse model with immune tolerance for human coagulation factor VIIa is …
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scholarly articleQ13442814

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P356DOI10.1007/S11095-013-1115-3
P698PubMed publication ID23775444
P5875ResearchGate publication ID239943117

P50authorBirgit ReipertQ104536448
Hans-Peter SchwarzQ108290186
P2093author name stringFriedrich Scheiflinger
Maria Schuster
Mantas Malisauskas
Gerhard Antoine
Markus Weiller
Sabine Unterthurner
Maurus de la Rosa
Christine Lenk
P2860cites workTreatment of congenital factor VII deficiency with a new concentrateQ67399902
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Life-threatening intracranial bleeding associated with the presence of an antifactor VII autoantibodyQ69663611
No simple solution for making transgenic miceQ69777598
The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse modelQ72643685
Long-term persistence of anti-factor VIII antibody-secreting cells in hemophilic mice after treatment with human factor VIIIQ74207828
Life-threatening bleeding in a case of autoantibody-induced factor VII deficiencyQ74593808
Generation of genetically-altered mice producing very low levels of coagulation factorVIIQ81438677
Nucleotide sequence of the gene coding for human factor VII, a vitamin K-dependent protein participating in blood coagulationQ22254871
Heterologous introns can enhance expression of transgenes in miceQ24561537
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Regulatory T cells exert checks and balances on self tolerance and autoimmunityQ28267935
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Structural characterization and immunogenicity in wild-type and immune tolerant mice of degraded recombinant human interferon alpha2b.Q30351459
Rat growth hormone gene introns stimulate nucleosome alignment in vitro and in transgenic miceQ34002397
Characterization of recombinant human factor IX expressed in transgenic mice and in derived trans-immortalized hepatic cell linesQ34077417
Mammalian cDNA and prokaryotic reporter sequences silence adjacent transgenes in transgenic miceQ34626392
Inhibitors in congenital coagulation disordersQ35937076
Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissueQ36404280
Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune diseaseQ37221573
Pharmacokinetics, pharmacodynamics and safety of recombinant canine FVIIa in a study dosing one haemophilia A and one haemostatically normal dog.Q37586365
Checkpoints in lymphocyte development and autoimmune diseaseQ37657051
Mechanisms maintaining peripheral tolerance.Q37657055
Localisation and trafficking of Toll-like receptors: an important mode of regulation.Q37671100
Defective vaccinia virus as a biologically safe tool for the overproduction of recombinant human secretory proteinsQ40981986
Expression of self-antigen in the thymus: a little goes a long way.Q42090814
A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) StudyQ42598903
Hepatocyte-specific expression of Cre recombinaseQ43604415
Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunityQ43996020
Phase I, randomized, double-blind, placebo-controlled, single-dose escalation study of the recombinant factor VIIa variant BAY 86-6150 in hemophiliaQ44355510
Transgenic mice as a model to test the immunogenicity of proteins altered by site-specific mutagenesisQ44969813
Antibodies to factor VIIa in patients with haemophilia and high-responding inhibitorsQ45855862
A prospective study of recombinant activated factor VII administered by continuous infusion to inhibitor patients undergoing elective major orthopaedic surgery: a pharmacokinetic and efficacy evaluationQ45858938
Maintenance and break of immune tolerance against human factor VIII in a new transgenic hemophilic mouse modelQ45871273
The LPS receptor (CD14) links innate immunity with Alzheimer's diseaseQ47405789
Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow.Q47848482
Amyloid beta peptide promotes differentiation of pro-inflammatory human myeloid dendritic cellsQ48093117
Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis.Q48176320
Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg(593) to Cys substitution.Q50652323
A mouse model for monitoring calpain activity under physiological and pathological conditions.Q51487311
Direct access to CD4+ T cells specific for defined antigens according to CD154 expression.Q52936537
MyD88 signaling controls autoimmune myocarditis induction.Q53641484
Development of a transgenic mouse model immune tolerant for human interferon Beta.Q54484718
A Role for Protein Misfolding in Immunogenicity of BiopharmaceuticalsQ58895670
P433issue11
P304page(s)2855-2867
P577publication date2013-06-18
P1433published inPharmaceutical ResearchQ7180737
P1476titleDevelopment of a transgenic mouse model with immune tolerance for human coagulation factor VIIa
P478volume30

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