Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia.

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Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/GLIA.23178
P698PubMed publication ID28618115

P50authorArne HolmgrenQ4794582
Hans-Peter HartungQ30001859
Christopher Horst LilligQ58231655
Eckhard BillQ69363862
P2093author name stringJens Ingwersen
Orhan Aktas
Carsten Berndt
Lawrence Steinman
Jack van Horssen
Rafael Radi
Reiner Schneider
Thomas Hildebrandt
Klaudia Lepka
Natalia Rios
Katrin Volbracht
Timur Prozorovski
P2860cites workCharacterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensorQ24529525
Oxidative stress: a concept in redox biology and medicineQ27022650
Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1pQ27931231
Multiple sclerosisQ28214785
The immunopathology of multiple sclerosis: an overviewQ28295115
Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signalingQ28389739
A simple method for organotypic cultures of nervous tissueQ29614375
Protein tyrosine nitration: biochemical mechanisms and structural basis of functional effectsQ30423705
Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1.Q30559574
Iron-sulfur cluster biosynthesisQ33685054
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytesQ33895965
Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c releaseQ34384165
Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesisQ34444269
How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2?Q34583043
Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondriaQ34583783
Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1.Q34650693
Expression pattern of human glutaredoxin 2 isoforms: identification and characterization of two testis/cancer cell-specific isoformsQ34727779
Iron-sulfur proteins are the major source of protein-bound dinitrosyl iron complexes formed in Escherichia coli cells under nitric oxide stress.Q34958579
Biochemistry of Nitric Oxide and Its Redox-Activated FormsQ35159350
Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexesQ35643805
Vertebrate-specific glutaredoxin is essential for brain developmentQ35651372
Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelinesQ35861182
Glutathione complexed Fe-S centers.Q36106847
The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseasesQ36552432
Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturationQ36926625
Cause and prevention of demyelination in a model multiple sclerosis lesion.Q37105517
Activation of Wnt signaling promotes hippocampal neurogenesis in experimental autoimmune encephalomyelitisQ37144845
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelinationQ37687158
Cells of the oligodendroglial lineage, myelination, and remyelinationQ37795984
The complex world of oligodendroglial differentiation inhibitorsQ37869047
Heterogeneity of CNS myeloid cells and their roles in neurodegenerationQ37939514
Iron metabolism in the CNS: implications for neurodegenerative diseasesQ38118885
The translational biology of remyelination: past, present, and futureQ38180416
Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.Q38230810
Iron-sulfur clusters as biological sensors: the chemistry of reactions with molecular oxygen and nitric oxideQ38254959
Nitrogen monoxide (no) and glucose: unexpected links between energy metabolism and no-mediated iron mobilization from cellsQ38306699
Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivoQ38320483
Demyelination induced by oxidative stress is regulated by sphingosine 1-phosphate receptors.Q38856184
Sensitive detection and estimation of cell-derived peroxynitrite fluxes using fluorescein-boronate.Q39376850
In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2.Q39753689
Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur clusterQ41814139
Redox regulation by glutathione needs enzymesQ42136449
Oxidation and S-nitrosylation of cysteines in human cytosolic and mitochondrial glutaredoxins: effects on structure and activity.Q42170005
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.Q42260800
Identification, expression pattern, and characterization of mouse glutaredoxin 2 isoforms.Q42594721
Interaction of reactive oxygen and nitrogen species with albumin- and methemoglobin-bound dinitrosyl-iron complexesQ46883473
Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in miceQ47275826
Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their developmentQ48367786
Hypotensive effect of Oxacom® containing a dinitrosyl iron complex with glutathione: animal studies and clinical trials on healthy volunteers.Q53665371
Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation.Q54405368
Contrasting potential of nitric oxide and peroxynitrite to mediate oligodendrocyte injury in multiple sclerosisQ57041843
Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytesQ57187456
Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibitionQ73643152
Dinitrosyl-dithiol-iron complexes, nitric oxide (NO) carriers in vivo, as potent inhibitors of human glutathione reductase and glutathione-S-transferaseQ73931678
The 2.03 signal as an indicator of dinitrosyl-iron complexes with thiol-containing ligandsQ77675198
Pathogenesis of multiple sclerosis: the eyes only see what the mind is prepared to comprehendQ79834864
Dinitrosyl iron complexes with thiol-containing ligands and apoptosis: studies with HeLa cell culturesQ83482452
Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiencyQ83680986
Distinct role of nitric oxide and peroxynitrite in mediating oligodendrocyte toxicity in culture and in experimental autoimmune encephalomyelitisQ83926672
Redox atlas of the mouse. Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouseQ84649121
P433issue9
P921main subjectoligodendrocyteQ916698
microgliaQ1622829
P304page(s)1521-1534
P577publication date2017-06-15
P1433published inGliaQ15716658
P1476titleIron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia.
P478volume65

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cites work (P2860)
Q49272997C-Phycocyanin and Phycocyanobilin as Remyelination Therapies for Enhancing Recovery in Multiple Sclerosis and Ischemic Stroke: A Preclinical Perspective
Q47740204Challenges and Opportunities for Small Molecule Fluorescent Probes in Redox Biology Applications.
Q97530084Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins
Q92856462Potential Immunotherapeutic Targets on Myeloid Cells for Neurovascular Repair After Ischemic Stroke
Q90776391Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

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