IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines.

scientific article published in August 2009

IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1189/JLB.0109046
P698PubMed publication ID19487306

P2093author name stringConsuelo Ortega
Ignacio J Molina
Manuel Santamaría
Pilar Romero
José C Moreno
Juan M Carrillo
Silvia Fernández-A
P2860cites workCyclosporine A inhibits IL-15-induced IL-17 production in CD4+ T cells via down-regulation of PI3K/Akt and NF-kappaB.Q38507718
Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse modelQ40156550
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cellsQ41687602
Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cellsQ41860308
Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.Q42417394
Serum levels of IL-17 and IL-22 are reduced by etanercept, but not by acitretin, in patients with psoriasis: a randomized-controlled trialQ46397390
Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear lateQ47588197
Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.Q50793292
Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.Q51974034
In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin.Q51985338
IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human.Q51994829
Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis.Q52026606
Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis?Q52970666
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionQ24314628
The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammationQ28266133
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gammaQ28506783
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generationQ29614840
Phenotypic and functional features of human Th17 cellsQ29619323
IL-17 family cytokines and the expanding diversity of effector T cell lineagesQ29619361
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosisQ29620506
Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responsesQ34369055
The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiatQ34505900
Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia.Q36229379
Getting under the skin: the immunogenetics of psoriasisQ36247085
Innate and adaptive immunity and the pathophysiology of psoriasisQ36400854
Pathogenesis and therapy of psoriasisQ36742020
Interleukin-17 in inflammatory skin disordersQ36943488
Explaining phenotype heterogeneity in patients with psoriasisQ37019141
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppressionQ37071969
Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasisQ37179608
P433issue2
P921main subjectcytotoxicityQ246181
P304page(s)435-443
P577publication date2009-08-01
P1433published inJournal of Leukocyte BiologyQ1524048
P1476titleIL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines.
P478volume86

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cites work (P2860)
Q38237063Brodalumab: an evidence-based review of its potential in the treatment of moderate-to-severe psoriasis
Q36980670CCR6 as a possible therapeutic target in psoriasis
Q30428781CD4+ and CD8+ T cell- and IL-17-mediated protection against Entamoeba histolytica induced by a recombinant vaccine
Q34611308CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis
Q58235912CD8 T Cells and IFN-γ Emerge as Critical Players for Psoriasis in a Novel Model of Mouse Psoriasiform Skin Inflammation
Q33866441CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease
Q38852309CD8(+) T cells in human autoimmune arthritis: the unusual suspects
Q36625142CD8(+) T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ
Q35758889CD8+ T cells induce thyroid epithelial cell hyperplasia and fibrosis
Q82661651CXCL16 and CXCR6 are upregulated in psoriasis and mediate cutaneous recruitment of human CD8+ T cells
Q38231403Cellular sources of IL-17 in psoriasis: a paradigm shift?
Q54394197Characterization of gliadin-specific Th17 cells from the mucosa of celiac disease patients.
Q38144211Chemokine receptors in psoriasis
Q43022569Childhood psoriasis: a study of 137 cases from central China
Q37352741Compartmentalized and systemic control of tissue immunity by commensals
Q33936619Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection
Q37313736Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models.
Q38553845Contribution of the IL-17 Pathway to Psoriasis and Psoriatic Arthritis
Q39028574Cytokines IL-17 and IL-22 in the host response to infection
Q28255491Cytokines in psoriasis
Q27334358Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis
Q54274575Different frequencies of Tc17/Tc1 and Th17/Th1 cells in chronic spontaneous urticaria.
Q29391765Differential Frequency of CD8+ T Cell Subsets in Multiple Sclerosis Patients with Various Clinical Patterns
Q58785143Distinguishing rheumatoid arthritis from psoriatic arthritis
Q64066277Distribution of Functional CD4 and CD8 T cell Subsets in Blood and Rectal Mucosal Tissues
Q34380190Divergent gene activation in peripheral blood and tissues of patients with rheumatoid arthritis, psoriatic arthritis and psoriasis following infliximab therapy
Q48244963Dust mite induces multiple polar T cell axes in human skin
Q33923351Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
Q39966021Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes
Q64102310Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation-Lessons From Rheumatoid Arthritis
Q36373858Effector T-cell subsets in systemic lupus erythematosus: update focusing on Th17 cells
Q39792098Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice
Q35105666Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection
Q36414419Epitope-specific CD8+ T cells play a differential pathogenic role in the development of a viral disease model for multiple sclerosis
Q56967563Expression of IL-17F is associated with non-pathogenic Th17 cells
Q44890278Gene-gene interactions in IL23/Th17 pathway contribute to psoriasis susceptibility in Chinese Han population
Q34254490Host defense mechanisms in secondary syphilitic lesions: a role for IFN-gamma-/IL-17-producing CD8+ T cells?
Q34456152Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells
Q38498941IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion
Q36807407IL-17 in psoriasis: implications for therapy and cardiovascular co-morbidities
Q61651896IL-17 in the immunopathogenesis of spondyloarthritis
Q35108924IL-17 induces an expanded range of downstream genes in reconstituted human epidermis model
Q38138107IL-17 producing T cells in celiac disease: angels or devils?
Q38111443IL-17 targeted therapies for psoriasis
Q38833064IL-17+ CD8+ T cells: Differentiation, phenotype and role in inflammatory disease
Q38081171IL-22, not simply a Th17 cytokine
Q26830943IL-23/IL-17A Dysfunction Phenotypes Inform Possible Clinical Effects from Anti-IL-17A Therapies
Q35779110IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
Q34059557Immune activation is associated with CD8 T cell interleukin-21 production in HIV-1-infected individuals
Q26995800Immunology of psoriasis
Q51603409Immunophenotyping of T cells in the peripheral circulation in psoriasis.
Q41865300In vitro induced CD8+ regulatory T cells inhibit skin inflammation
Q47824146Increased Th22 cells are independently associated with Th17 cells in type 1 diabetes.
Q36484115Increased expression of interleukin-17 pathway genes in nonlesional skin of moderate-to-severe psoriasis vulgaris
Q33815062Increasing a robust antigen-specific cytotoxic T lymphocyte response by FMDV DNA vaccination with IL-9 expressing construct.
Q30589228Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase.
Q37921634Innate immunity in the pathogenesis of psoriasis.
Q28298644Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis
Q34181184Interferon-β exacerbates Th17-mediated inflammatory disease
Q38379864Interleukin-17 antagonists in the treatment of psoriasis
Q34154244Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression
Q36826339Interleukin-21 overexpression dominates T cell response to Epstein-Barr virus in a fatal case of X-linked lymphoproliferative syndrome type 1
Q24629567Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers
Q34388287Interleukin-21: a multifunctional regulator of immunity to infections
Q34551370Intestinal T-cell responses in celiac disease - impact of celiac disease associated bacteria
Q24626968Lifting the silver flakes: the pathogenesis and management of chronic plaque psoriasis
Q90733175Loss of TIPE2 Has Opposing Effects on the Pathogenesis of Autoimmune Diseases
Q38040302MODULATING CO-STIMULATION DURING ANTIGEN PRESENTATION TO ENHANCE CANCER IMMUNOTHERAPY.
Q39417348Mustard seed (Sinapis Alba Linn) attenuates imiquimod-induced psoriasiform inflammation of BALB/c mice
Q34043846New insights of T cells in the pathogenesis of psoriasis
Q58724084Novel Concepts in Psoriatic Arthritis Management: Can We Treat to Target?
Q47859049Old and New Biological Therapies for Psoriasis.
Q26751101Periodontal Systemic Connections-Novel Associations-A Review of the Evidence with Implications for Medical Practitioners
Q34426538Periodontal disease and risk of psoriasis among nurses in the United States
Q36797792Peripheral Tc17 and Tc17/Interferon-γ Cells are Increased and Associated with Lung Function in Patients with Chronic Obstructive Pulmonary Disease
Q47097758Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.
Q58235909Psoriasis
Q34495706Psoriasis and the MAITing game: a role for IL-17A+ invariant TCR CD8+ T cells in psoriasis?
Q37789387Psoriasis: from pathogenesis to novel therapeutic approaches
Q38020227Psoriasis: rationale for targeting interleukin-17.
Q64925719RNA-seq and flow-cytometry of conventional, scalp, and palmoplantar psoriasis reveal shared and distinct molecular pathways.
Q53033887Rationale for the development of speckled hyperpigmentation in the areas of psoriatic plaques after treatment with biologic agents.
Q26800988Regulation of Dendritic Cell Function in Inflammation
Q59798737Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse?
Q90103308Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp
Q38190986Role of IL-23 in the pathogenesis of psoriasis: a novel potential therapeutic target?
Q38991358Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers
Q48278167Scanning the Immunopathogenesis of Psoriasis
Q46453213Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, exhibits minimal immunogenicity in patients with moderate-to-severe plaque psoriasis
Q37138974Secukinumab, a novel anti-IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity
Q55512008T Cell Hierarchy in the Pathogenesis of Psoriasis and Associated Cardiovascular Comorbidities.
Q28069848T Helper Cell Subsets in Clinical Manifestations of Psoriasis
Q38042048Targeting the Th17 pathway in psoriasis
Q34856750Tc17 CD8 T cells: functional plasticity and subset diversity.
Q35093526Tc17 cells in patients with uterine cervical cancer
Q88110812The IL-17A-producing CD8+ T-cell population in psoriatic lesional skin comprises mucosa-associated invariant T cells and conventional T cells
Q64063151The Number of Donor-Specific IL-21 Producing Cells Before and After Transplantation Predicts Kidney Graft Rejection
Q42860267The Role of Etanercept on the Expression of Markers of T Helper 17 Cells and Their Precursors in Skin Lesions of Patients with Psoriasis Vulgaris
Q52337140The current status, challenges, and future developments of new tuberculosis vaccines.
Q24623195The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings
Q33640627The immunologic effects of estrogen on psoriasis: A comprehensive review
Q91664106The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies
Q38184626The role of innate and lymphoid IL-22-producing cells in the immunopathology of primary Sjögren's syndrome.
Q38217029The role of interleukin-17A in psoriatic disease
Q38349779Tofacitinib for the treatment of moderate-to-severe psoriasis
Q55709454Typhus Group Rickettsiosis, Germany, 2010-20171.
Q58544217Understanding psoriasis: Role of miRNAs
Q27304934Use of praziquantel as an adjuvant enhances protection and Tc-17 responses to killed H5N1 virus vaccine in mice
Q52883792[Expression and role of Tc17 cells in mice with neutrophilic asthma].
Q35141744β2-Adrenergic agonists bias TLR-2 and NOD2 activated dendritic cells towards inducing an IL-17 immune response

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