Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.

scientific article published on 30 June 2017

Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/ACS.JMEDCHEM.7B00360
P698PubMed publication ID28665128

P50authorKen A. BrameldQ42723561
P2093author name stringJ Michael Bradshaw
David M Goldstein
Eleni Venetsanakos
Timothy D Owens
Mary E Gerritsen
Jin Shu
Danny Tam
David G Loughhead
Erik Verner
Kwan Leung
Vernon T Phan
Dane E Karr
Jens Oliver Funk
Tony Ton
Jacob LaStant
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)6516-6527
P577publication date2017-06-30
P1433published inJournal of Medicinal ChemistryQ900316
P1476titleDiscovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.
P478volume60

Reverse relations

cites work (P2860)
Q93382470C11, a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis
Q91995280Covalent Inhibition in Drug Discovery
Q104111296DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro and in vivo
Q64118758Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines
Q92879928Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors
Q88959338Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer
Q60302361Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting
Q62230924TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure
Q93048955Targeting the Oncogenic FGF-FGFR Axis in Gastric Carcinogenesis

Search more.