APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.

scientific article

APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HUMU.21027
P698PubMed publication ID19462468
P5875ResearchGate publication ID24446548

P50authorChristine Van BroeckhovenQ2247235
Nathalie BrouwersQ47910878
Sebastiaan EngelborghsQ56616406
Peter Paul De DeynQ60327954
Karolien BettensQ114407921
Helen Van MiegroetQ114407948
Kristel SleegersQ28480858
Jessie TheunsQ42757468
P2860cites workGenetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's diseaseQ48437807
Dose dependent effect of APOE epsilon4 on behavioral symptoms in frontal lobe dementia.Q51922561
The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years.Q53272791
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease PathwaysQ57982495
Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patientsQ24633400
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretaseQ24643985
The microRNA.org resource: targets and expressionQ24650094
microRNA target predictions across seven Drosophila species and comparison to mammalian targetsQ24811535
“Mini-mental state”Q25938989
Prediction of mammalian microRNA targetsQ27860498
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's DiseaseQ27860795
BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's diseaseQ28257726
APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathyQ28259007
Sequence variants in SLITRK1 are associated with Tourette's syndromeQ28276961
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathyQ28288090
A brain-specific microRNA regulates dendritic spine developmentQ29614753
Characterization of microRNA expression profiles in normal human tissuesQ29615492
The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.Q33722837
Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer diseaseQ34658251
Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinomaQ34778280
Beta-secretase activity increases with aging in human, monkey, and mouse brain.Q35083409
Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effectsQ35475856
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's diseaseQ36564159
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expressionQ36609033
Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and diseaseQ36806008
Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA.Q40151267
BACE1 gene promoter is differentially regulated: detection of a novel promoter region for its cell type-specific regulationQ40282792
Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expressionQ40570846
A hexanucleotide element directs microRNA nuclear import.Q41412805
MicroRNAs can regulate human APP levels.Q42426890
Gene structure and organization of the human beta-secretase (BACE) promoter.Q42459613
Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.Q42664113
Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutationQ43565734
Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's diseaseQ43783045
Set of novel tools for PCR primer designQ43840649
Increased expression of the amyloid precursor beta-secretase in Alzheimer's diseaseQ44060098
Beta-secretase protein and activity are increased in the neocortex in Alzheimer diseaseQ44132132
P433issue8
P921main subjectAlzheimer's diseaseQ11081
P304page(s)1207-1213
P577publication date2009-08-01
P1433published inHuman MutationQ5937269
P1476titleAPP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.
P478volume30

Reverse relations

cites work (P2860)
Q36911784Abnormal Changes of Brain Cortical Anatomy and the Association with Plasma MicroRNA107 Level in Amnestic Mild Cognitive Impairment
Q21202833Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
Q53317692Amyloid precursor protein gene (APP) variation in late-onset Alzheimer's disease.
Q52622902Association between BACE1 gene polymorphisms and focal seizures in a Chinese Han population.
Q33929052Brain-specific knockdown of miR-29 results in neuronal cell death and ataxia in mice
Q33871345Current status on Alzheimer disease molecular genetics: from past, to present, to future
Q34323841Epigenetic memory: the Lamarckian brain
Q34312041Exosome-mediated delivery of siRNA in vitro and in vivo
Q43873373Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression
Q37642149MicroRNA-29a modulates axon branching by targeting doublecortin in primary neurons
Q37800789MicroRNAs and Their Therapeutic Potential for Human Diseases: Aberrant MicroRNA Expression in Alzheimer’s Disease Brains
Q34101214MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration
Q36602107MicroRNAs in age-related diseases
Q37946984MicroRNAs in neurodegenerative diseases and their therapeutic potential.
Q36695844Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy
Q26859224Neuronal dark matter: the emerging role of microRNAs in neurodegeneration
Q38051212Non-coding RNAs in Alzheimer's disease
Q38799079Recombinant pre-miR-29b for Alzheimer´s disease therapeutics
Q35883202Role of common and rare APP DNA sequence variants in Alzheimer disease
Q46624520The Emerging Role of MitomiRs in the Pathophysiology of Human Disease
Q51760979The Role of microRNAs in Alzheimer's Disease and Their Therapeutic Potentials.
Q33995527Understanding microRNAs in neurodegeneration
Q50609525miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3.

Search more.