Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells

scientific article published on 20 April 2009

Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/INTIMM/DXP037
P698PubMed publication ID19380384

P50authorKei IkedaQ55293595
P2093author name stringKoichi Hirose
Akira Suto
Hiroshi Nakajima
Itsuo Iwamoto
Shin-ichiro Kagami
Norihiko Watanabe
Takayoshi Owada
Yukari Saito
Hiroko Kanari
P2860cites workTGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionQ24314628
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cellsQ24547568
Pleiotropic effects of statinsQ24647863
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
Rho GTPases in cell biologyQ27860969
Statin therapy and autoimmune disease: from protein prenylation to immunomodulationQ28236647
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cellsQ28257250
TH17 cells in development: an updated view of their molecular identity and genetic programmingQ28276449
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damageQ28287540
Protein prenylation: molecular mechanisms and functional consequencesQ29618038
Molecular antagonism and plasticity of regulatory and inflammatory T cell programsQ29619478
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammationQ33876035
Signaling and transcription in T helper developmentQ33932729
Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trialQ34327988
Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune diseaseQ34556560
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatinQ36228304
Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatinQ36370581
IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-alpha production in mast cells.Q36371553
SOCS proteins, cytokine signalling and immune regulationQ36831668
Th17 cell differentiation: the long and winding roadQ37133442
Development and characterization of IL-21-producing CD4+ T cellsQ38845667
Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivoQ43687301
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune diseaseQ43934617
Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levelsQ44509632
Statins induce suppressor of cytokine signaling-3 in macrophagesQ44673403
Oral simvastatin treatment in relapsing-remitting multiple sclerosisQ44897670
Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.Q46614190
IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cellsQ50885474
P433issue6
P304page(s)679-689
P577publication date2009-04-20
P1433published inInternational ImmunologyQ15710043
P1476titleProtein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells
P478volume21

Reverse relations

cites work (P2860)
Q58412743AT-Rich-Interactive Domain-Containing Protein 5A Functions as a Negative Regulator of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γt-Induced Th17 Cell Differentiation
Q43218018Atorvastatin attenuates murine anti-glomerular basement membrane glomerulonephritis
Q64096419Contribution of Statins towards Periodontal Treatment: A Review
Q35579498Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance
Q90389973Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology
Q92803859Immunometabolic cross-talk in the inflamed heart
Q90058507Inhibition of stearoyl-CoA desaturases suppresses follicular help T- and germinal center B- cell responses
Q37811625Innate and adaptive interleukin-17-producing lymphocytes in chronic inflammatory lung disorders
Q92569677Metabolic regulation of TH17 cells
Q97692681Metabolic signaling in T cells
Q90290841Mevalonate promotes differentiation of regulatory T cells
Q43139805New insight into the immunomodulatory mechanisms of Tretinoin in NMRI mice
Q52688337Pattern of risks of rheumatoid arthritis among patients using statins: A cohort study with the clinical practice research datalink.
Q45772626Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice.
Q39069187Pleiotropic Effects of Statins on the Cardiovascular System
Q49861299Regulatory T Cell Metabolism in the Hepatic Microenvironment
Q43090511Simvastatin induces Foxp3+ T regulatory cells by modulation of transforming growth factor-beta signal transduction
Q26738584Stabilization of high-risk plaques
Q35023243Statin use and markers of immunity in the Doetinchem cohort study
Q33576127Statin use in giant cell arteritis: a retrospective study
Q38162189Statins as modulators of regulatory T-cell biology.
Q53123972Statins enhance the effects of corticosteroids on the balance between regulatory T cells and Th17 cells.
Q28254889Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists
Q51201110Synergistic effects of atorvastatin and all-trans retinoic acid in ameliorating animal model of multiple sclerosis.
Q39062582Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome
Q64248997The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia
Q49630753The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival
Q37772197The combination of interferon-beta and HMG-CoA reductase inhibition in multiple sclerosis: enthusiasm lost too soon?
Q35635336The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells
Q37137525mTOR and lymphocyte metabolism

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