EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor

scientific article published on 9 March 2009

EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/ONC.2009.15
P698PubMed publication ID19270726
P5875ResearchGate publication ID24186124

P2093author name stringD Xie
J-J Li
G-T Liu
D-P Liu
P2860cites workCompartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesionQ24596866
Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cellsQ24655999
Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6Q28143384
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligaseQ28145635
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesisQ28286738
The role of ephrins and Eph receptors in cancerQ28294851
Regulation of angiogenesis by Eph-ephrin interactionsQ28306625
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1Q29617290
Cloning and characterization of the promoter region of the rat epidermal growth factor receptor gene and its transcriptional regulation by nerve growth factor in PC12 cellsQ30843762
Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinasesQ32062433
Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survivalQ33245287
Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell functionQ33273613
Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-CblQ33292321
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.Q34169244
Differential gene expression of Eph receptors and ephrins in benign human tissues and cancersQ34290211
Ephrin-As mediate targeting of eye-specific projections to the lateral geniculate nucleusQ34434701
Multiple roles of ephrins during the formation of thalamocortical projections: maps and moreQ35685283
Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assemblyQ35911289
Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumoursQ36400537
Epidermal growth factor receptor - mediated signal transduction in the development and therapy of gliomasQ36692599
Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signalingQ40064482
Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motilityQ40156318
c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomesQ40542743
A new ephrin-A1 isoform (ephrin-A1b) with altered receptor binding properties abrogates the cleavage of ephrin-A1a.Q40604541
Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cellsQ40641471
Negative regulation of EphA2 receptor by Cbl.Q40714708
Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptorQ42833869
Estrogen suppression of EGFR expression in breast cancer cells: a possible mechanism to modulate growthQ43676061
Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis.Q44124165
Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathwaysQ47937413
Ephrin-A5 modulates the topographic mapping and connectivity of commissural axons in murine hippocampusQ48544430
Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in miceQ79322834
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)1759-1768
P577publication date2009-03-09
P1433published inOncogeneQ1568657
P1476titleEphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor
P478volume28

Reverse relations

cites work (P2860)
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Q39445033EphrinA5 suppresses colon cancer development by negatively regulating epidermal growth factor receptor stability
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