Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition.

scientific article published on 31 May 2017

Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition. is …
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scholarly articleQ13442814

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P356DOI10.1073/PNAS.1617799114
P932PMC publication ID5474788
P698PubMed publication ID28566496

P50authorGary P. MoranQ37830355
Peter FlanaganQ56864547
P2093author name stringNing-Ning Liu
Maria E Cardenas
Julia R Köhler
Niketa M Jani
Jumei Zeng
P2860cites workrheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related proteinQ24316714
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The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamineQ27930850
TOR controls translation initiation and early G1 progression in yeastQ27931425
Inorganic phosphate is sensed by specific phosphate carriers and acts in concert with glucose as a nutrient signal for activation of the protein kinase A pathway in the yeast Saccharomyces cerevisiaeQ27933671
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SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulationQ27936100
Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2pQ27936663
TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0.Q27937727
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Mds3 regulates morphogenesis in Candida albicans through the TOR pathwayQ27940288
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Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TORQ28361576
The protein kinase Tor1 regulates adhesin gene expression in Candida albicansQ28474672
The TOR signaling cascade regulates gene expression in response to nutrientsQ29620801
Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasisQ30806103
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An intracellular phosphate buffer filters transient fluctuations in extracellular phosphate levelsQ33863399
The TOR signal transduction cascade controls cellular differentiation in response to nutrientsQ33948836
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Probing in vivo Mn2+ speciation and oxidative stress resistance in yeast cells with electron-nuclear double resonance spectroscopyQ34100282
The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrataQ34230692
Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex.Q34324953
A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosisQ34513852
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Gln3 phosphorylation and intracellular localization in nutrient limitation and starvation differ from those generated by rapamycin inhibition of Tor1/2 in Saccharomyces cerevisiaeQ35240370
Target of rapamycin (TOR) in nutrient signaling and growth controlQ35620394
Rhb1 regulates the expression of secreted aspartic protease 2 through the TOR signaling pathway in Candida albicansQ35738990
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Positive feedback regulates switching of phosphate transporters in S. cerevisiaeQ36082999
An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal PathogensQ36304381
Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphateQ36631844
Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiaeQ36648724
Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiaeQ36734708
The Candida albicans Pho4 Transcription Factor Mediates Susceptibility to Stress and Influences Fitness in a Mouse Commensalism Model.Q37072222
Rapamycin bypasses vesicle-mediated signaling events to activate Gln3 in Saccharomyces cerevisiaeQ37079571
The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferationQ37081595
Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system.Q37336948
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Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiaeQ37696384
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Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growthQ40895746
CaNAT1, a heterologous dominant selectable marker for transformation of Candida albicans and other pathogenic Candida speciesQ40998517
Ribosomal protein S6 phosphorylation is controlled by TOR and modulated by PKA in Candida albicansQ41109006
Comparison of caspofungin and amphotericin B for invasive candidiasisQ44255071
The serine/threonine protein phosphatase SIT4 modulates yeast-to-hypha morphogenesis and virulence in Candida albicansQ44734060
A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicansQ45826960
Mutational analysis of putative phosphate- and proton-binding sites in the Saccharomyces cerevisiae Pho84 phosphate:H(+) transceptor and its effect on signalling to the PKA and PHO pathwaysQ48526911
Structure and function of the GTP binding protein Gtr1 and its role in phosphate transport in Saccharomyces cerevisiae.Q50781350
Intracellular phosphate serves as a signal for the regulation of the PHO pathway in Saccharomyces cerevisiae.Q51035160
Adaptation to Pi deprivation of cell Na-dependent Pi uptake: a widespread processQ69331364
Mutagenic and functional analysis of the C-terminus of Saccharomyces cerevisiae Pho84 phosphate transporterQ74709823
P4510describes a project that usesImageJQ1659584
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectCandida albicansQ310443
P1104number of pages6
P304page(s)6346-6351
P577publication date2017-05-31
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePhosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition
P478volume114