Understanding how pharmacokinetic and pharmacodynamic differences of basal analog insulins influence clinical practice.

scientific article

Understanding how pharmacokinetic and pharmacodynamic differences of basal analog insulins influence clinical practice. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1080/03007995.2017.1335192
P698PubMed publication ID28537449

P50authorJennifer GoldmanQ88044789
P2093author name stringJeremy Pettus
Tim Heise
Christoph Kapitza
P2860cites workBiosimilar insulins: a European perspectiveQ27026596
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Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority triaQ34269834
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The efficacy and safety of insulin degludec given in variable once-daily dosing intervals compared with insulin glargine and insulin degludec dosed at the same time daily: a 26-week, randomized, open-label, parallel-group, treat-to-target trial in iQ36720304
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Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studiesQ36889115
Low-volume insulin degludec 200 units/ml once daily improves glycemic control similarly to insulin glargine with a low risk of hypoglycemia in insulin-naive patients with type 2 diabetes: a 26-week, randomized, controlled, multinational, treat-to-taQ37106509
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A review of modern insulin analogue pharmacokinetic and pharmacodynamic profiles in type 2 diabetes: improvements and limitationsQ37853658
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Insulin glargine metabolite 21(A) -Gly-human insulin (M1) is the principal component circulating in the plasma of young children with type 1 diabetes: results from the PRESCHOOL studyQ38426608
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Similar risk of exercise-related hypoglycaemia for insulin degludec to that for insulin glargine in patients with type 1 diabetes: a randomized cross-over trialQ42383447
Basal insulin and cardiovascular and other outcomes in dysglycemiaQ42507791
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Insulin detemir offers improved glycemic control compared with NPH insulin in people with type 1 diabetes: a randomized clinical trialQ42625907
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Biotransformation of insulin glargine after subcutaneous injection in healthy subjectsQ44379874
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A comparison of the steady-state pharmacokinetic and pharmacodynamic profiles of 100 and 200 U/mL formulations of ultra-long-acting insulin degludecQ44599380
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Once-daily initiation of basal insulin as add-on to metformin: a 26-week, randomized, treat-to-target trial comparing insulin detemir with insulin glargine in patients with type 2 diabetesQ45127422
Contribution of the dawn phenomenon to the fasting and postbreakfast hyperglycemia in type 1 diabetes treated with once-nightly insulin glargineQ46060194
Reduced risk of hypoglycemia with insulin degludec versus insulin glargine in patients with type 2 diabetes requiring high doses of basal insulin: a meta-analysis of 5 randomized begin trialsQ46129839
Efficacy and Safety of Insulin Degludec 200 U/mL and Insulin Degludec 100 U/mL in Patients with Type 2 Diabetes (Begin: Compare).Q46247786
Steady state is reached within 2-3 days of once-daily administration of degludec, a basal insulin with an ultralong duration of actionQ46358093
Reduced hypoglycemia risk with insulin glargine: a meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetesQ46406475
The interpretation of glucose clamp studies of long-acting insulin analogues: from physiology to marketing and back.Q46452341
A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir.Q46458876
A randomized multicentre trial of insulin glargine compared with NPH insulin in people with type 1 diabetesQ46602351
Fluctuation and reproducibility of exposure and effect of insulin glargine in healthy subjectsQ46691043
Pharmacokinetic and glucodynamic variability: assessment of insulin glargine, NPH insulin and insulin ultralente in healthy volunteers using a euglycaemic clamp techniqueQ46701751
Comparison of insulin detemir and insulin glargine in subjects with Type 1 diabetes using intensive insulin therapyQ46707992
Insulin detemir results in less weight gain than NPH insulin when used in basal-bolus therapy for type 2 diabetes mellitus, and this advantage increases with baseline body mass indexQ47297341
Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady-state conditions in type 1 diabetesQ49174475
Sustained glycaemic control and less nocturnal hypoglycaemia with insulin glargine 300U/mL compared with glargine 100U/mL in Japanese adults with type 1 diabetes (EDITION JP 1 randomised 12-month trial including 6-month extension).Q51068494
A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in patients with type 1 diabetes.Q51552514
Basal insulin glargine (HOE 901) versus NPH insulin in patients with type 1 diabetes on multiple daily insulin regimens. U.S. Insulin Glargine (HOE 901) Type 1 Diabetes Investigator Group.Q51554474
New Insulin Glargine 300 Units/mL Versus Glargine 100 Units/mL in People With Type 1 Diabetes: A Randomized, Phase 3a, Open-Label Clinical Trial (EDITION 4).Q53211985
Comparison of the Pharmacokinetics and Pharmacodynamics of LY2963016 Insulin Glargine and EU- and US-Approved Versions of Lantus Insulin Glargine in Healthy Subjects: Three Randomized Euglycemic Clamp Studies.Q53790905
Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.Q55034466
The Mechanism of Protraction of Insulin Detemir, a Long-Acting, Acylated Analog of Human InsulinQ57599459
A 26-Week, Randomized, Parallel, Treat-to-Target Trial Comparing Insulin Detemir With NPH Insulin as Add-On Therapy to Oral Glucose-Lowering Drugs in Insulin-Naive People With Type 2 DiabetesQ59311920
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
pharmacodynamicsQ725307
P304page(s)1821-1831
P577publication date2017-06-23
P1433published inCurrent Medical Research and OpinionQ5195063
P1476titleUnderstanding how pharmacokinetic and pharmacodynamic differences of basal analog insulins influence clinical practice
P478volume33

Reverse relations

cites work (P2860)
Q89484275Adjustment of insulin doses when switching from glargine 100 U/ml or detemir to degludec: an observational study
Q64904369Basal insulin reductions in anticipation of multiple exercise sessions in people with type 1 diabetes-a clinical perspective.
Q90206853Cost analysis of insulin degludec in comparison with insulin detemir in treatment of children and adolescents with type 1 diabetes in the UK
Q92721967Differentiating Basal Insulin Preparations: Understanding How They Work Explains Why They Are Different
Q92100367Glargine-300: An updated literature review on randomized controlled trials and real-world studies
Q53448284Insulin Matters: A Practical Approach to Basal Insulin Management in Type 2 Diabetes.
Q57026285Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Q56979722Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Q92188767Nocturnal Glycemic Control with New Insulin Glargine 300 U/mL
Q58712651Switching From Glargine to Degludec: The Effect on Metabolic Control and Safety During 1-Year of Real Clinical Practice in Children and Adolescents With Type 1 Diabetes
Q64039667The basal to total insulin ratio in outpatients with diabetes on basal-bolus regimen

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