Telomerase activity is required for the telomere G-overhang structure in Trypanosoma brucei.

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Telomerase activity is required for the telomere G-overhang structure in Trypanosoma brucei. is …
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scholarly articleQ13442814

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P356DOI10.1038/S41598-017-16182-Y
P8608Fatcat IDrelease_67ispoaugndm3mkclidvg2a32u
P932PMC publication ID5700094
P698PubMed publication ID29167542

P50authorBibo LiQ89379288
P2093author name stringRanjodh Sandhu
P2860cites workTelomeric expression sites are highly conserved in Trypanosoma bruceiQ21144222
Mammalian telomeres end in a large duplex loopQ22009893
Eukaryotic DNA PolymerasesQ22065416
Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunitQ24291434
Telomere structure and shortening in telomerase-deficient Trypanosoma bruceiQ24812475
Structure and function of the telomeric CST complexQ26745414
Telomeres-structure, function, and regulationQ26853108
Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres.Q27931150
Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae.Q27931375
A short C-terminal domain of Yku70p is essential for telomere maintenanceQ27935969
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeresQ28118408
Division of labor at the eukaryotic replication forkQ28277921
Telomere length regulationQ28290143
Identification of a specific telomere terminal transferase activity in Tetrahymena extractsQ28306745
G-overhang dynamics at Tetrahymena telomeresQ28345104
Apollo contributes to G overhang maintenance and protects leading-end telomeresQ28585996
A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma bruceiQ29617358
Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomeraseQ30459426
Monovalent cation-induced structure of telomeric DNA: the G-quartet modelQ30459609
Organization of telomeric and sub-telomeric regions of chromosomes from the protozoan parasite Trypanosoma cruziQ30726601
Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activityQ30860113
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes endQ33217702
Leishmania replication protein A-1 binds in vivo single-stranded telomeric DNA.Q33284488
TOPO3alpha influences antigenic variation by monitoring expression-site-associated VSG switching in Trypanosoma bruceiQ33632168
Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybridsQ33741172
Telomere length regulation and transcriptional silencing in KU80-deficient Trypanosoma bruceiQ33754475
Trypanosome telomeres are protected by a homologue of mammalian TRF2.Q33836828
End resection at double-strand breaks: mechanism and regulationQ33938581
Predominance of duplicative VSG gene conversion in antigenic variation in African trypanosomesQ33959039
Identification of Trypanosoma brucei RMI1/BLAP75 homologue and its roles in antigenic variationQ34043078
Antigenic variation in trypanosomes: enhanced phenotypic variation in a eukaryotic parasiteQ34084350
t-loops at trypanosome telomeres.Q34271330
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenanceQ34411525
The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complexQ34510751
Telomere maintenance without telomeraseQ34535615
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificityQ34687302
Telomeric overhang length determines structural dynamics and accessibility to telomerase and ALT-associated proteinsQ35170132
The putative Leishmania telomerase RNA (LeishTER) undergoes trans-splicing and contains a conserved template sequenceQ35414757
Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomeraseQ35936207
Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shorteningQ36020875
Extensive allelic variation and ultrashort telomeres in senescent human cells.Q53659799
Telomere end-replication problem and cell agingQ56508218
Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosomeQ56969779
Growth of chromosome ends in multiplying trypanosomesQ67297495
Terminal labeling and addition of homopolymer tracts to duplex DNA fragments by terminal deoxynucleotidyl transferaseQ67482641
Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phaseQ70535280
Charaterization of Leishmania major Friedlin telomeric terminusQ74239938
Analysis of the G-overhang structures on plant telomeres: evidence for two distinct telomere architecturesQ74267224
Telomere-end processing the terminal nucleotides of human chromosomesQ81610331
Trypanosoma brucei TIF2 and TRF Suppress VSG Switching Using Overlapping and Independent MechanismsQ36039757
Terminal labeling and addition of homopolymer tracts to duplex DNA fragments by terminal deoxynucleotidyl transferaseQ36193072
Closed chromatin loops at the ends of chromosomesQ36322309
Telomere length homeostasisQ36495238
Complex interactions between the DNA-damage response and mammalian telomeresQ36539673
A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma bruceiQ36739974
Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loopsQ36745869
Replication of telomeres and the regulation of telomeraseQ36783452
CST for the grand finale of telomere replication.Q37260942
Telomere-end processing: mechanisms and regulationQ38152264
The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activitiesQ38335557
Examination of the telomere G-overhang structure in Trypanosoma bruceiQ38588525
Molecular mechanisms of activity and derepression of alternative lengthening of telomeresQ38637725
Consider the workhorse: Nonhomologous end-joining in budding yeastQ38848161
Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protectionQ39678675
G-strand overhangs on telomeres in telomerase-deficient mouse cellsQ39729234
Human telomeres have different overhang sizes at leading versus lagging strandsQ40321395
Differential size variations between transcriptionally active and inactive telomeres ofTrypanosoma bruceiQ40494807
Role of human Ku86 in telomere length maintenance and telomere cappingQ40502741
Telomerase-dependent generation of 70-nt-long telomeric single-stranded 3' overhangs in yeast.Q41431137
Trypanosoma brucei TIF2 suppresses VSG switching by maintaining subtelomere integrityQ42065326
Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.Q42230020
Trypanosoma brucei Orc1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switching.Q42283703
Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma bruceiQ42321946
Inactivation of Mre11 does not affect VSG gene duplication mediated by homologous recombination in Trypanosoma brucei.Q43993843
Trypanosoma brucei MRE11 is non-essential but influences growth, homologous recombination and DNA double-strand break repair.Q44239903
Telomerase-dependent 3' G-strand overhang maintenance facilitates GTBP1-mediated telomere protection from misplaced homologous recombinationQ45066501
Cloning and characterization of Leishmania donovani telomeresQ47857659
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectTrypanosoma bruceiQ33244
P304page(s)15983
P577publication date2017-11-22
P1433published inScientific ReportsQ2261792
P1476titleTelomerase activity is required for the telomere G-overhang structure in Trypanosoma brucei
P478volume7

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Q59805089Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomescites workP2860

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