DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6.

scientific article published on 12 December 2017

DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1099597943
P356DOI10.1186/S12974-017-1020-5
P932PMC publication ID5727666
P698PubMed publication ID29233148

P50authorStephen L. LeibQ38545095
Lucymara Fassarella Agnez-LimaQ44615668
P2093author name stringAna Helena Sales de Oliveira
Leonam G Coutinho
Matthias Witwer
P2860cites workCleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme AQ24338600
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells.Q27863389
Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c releaseQ28374462
Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogensQ28575769
Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repairQ28645611
Gene expression in cortex and hippocampus during acute pneumococcal meningitisQ30817171
Vitamin B6: a molecule for human health?Q34616300
Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis.Q34974364
Genetic polymorphisms associated with the inflammatory response in bacterial meningitis.Q35758305
Endonuclease activation and chromosomal DNA fragmentation during apoptosis in leukemia cellsQ36546910
Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responsesQ36964999
Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococciQ37361937
Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation statusQ37474800
A short review on the implications of base excision repair pathway for neurons: relevance to neurodegenerative diseasesQ38162036
Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1.Q38330113
Role of DNA repair in host immune response and inflammationQ38385882
The role of excitotoxic programmed necrosis in acute brain injuryQ38429588
Management of bacterial central nervous system infectionsQ39130658
Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosisQ41115305
Caspase-mediated apoptosis in neuronal excitotoxicity triggered by nitric oxideQ41889949
Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathwayQ42007394
Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosisQ42169230
Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.Q42264580
Oxidative cellular damage and the reduction of APE/Ref-1 expression after experimental traumatic brain injuryQ43669930
Oxidative damage and reduction of redox factor-1 expression after transient spinal cord ischemia in rabbitsQ44300418
Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis.Q44391608
Activated monocytes induce human retinal pigment epithelial cell apoptosis through caspase-3 activationQ44550675
Brain-derived neurotrophic factor protects against multiple forms of brain injury in bacterial meningitisQ45184004
Changes in immunoreactivity of HSP60 and its neuroprotective effects in the gerbil hippocampal CA1 region induced by transient ischemiaQ46954822
A new specialization in astrocytes: glutamate- and ammonia-induced nuclear size changesQ47378014
Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats: implication of the failure of DNA repair in neuronal apoptosisQ48290228
Pneumococcal meningitis induces apoptosis in recently postmitotic immature neurons in the dentate gyrus of neonatal ratsQ48346613
Effects of pyridoxine withdrawal on cerebral circulation and metabolism in a pyridoxine-dependent child.Q51316143
An infant mouse model of brain damage in pneumococcal meningitis.Q51970633
SNPs in DNA repair genes associated to meningitis and host immune responseQ57253143
The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stressQ64379010
Neuroprotective effects of an antioxidant in cortical cerebral ischemia: prevention of early reduction of the apurinic/apyrimidinic endonuclease DNA repair enzymeQ73375115
P433issue1
P921main subjectmeningitisQ48143
vitamin BQ183206
vitamin B6Q205130
pneumococcal meningitisQ3854685
P304page(s)243
P577publication date2017-12-12
P1433published inJournal of NeuroinflammationQ15716679
P1476titleDNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6
P478volume14

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cites work (P2860)
Q91962041Zymolytic Grain Extract (ZGE) Significantly Extends the Lifespan and Enhances the Environmental Stress Resistance of Caenorhabditis elegans
Q90613916sRNA OsiA Stabilizes Catalase mRNA during Oxidative Stress Response of Deincoccus radiodurans R1

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